Hyperprolactinemia and bone
Por:
di Filippo, L, Doga, M, Resmini, E, Giustina, A
Publicada:
1 jun 2020
Ahead of Print:
1 mar 2020
Resumen:
Prolactin (PRL) has direct and indirect effects on bone metabolism. Experimental studies showed that in the presence of high PRL levels bone resorption was increased as well as bone formation was suppressed. Increased PRL levels in humans caused a reduction in sex hormone levels which turn may have detrimental effects on bone. Patients with hyperprolactinemia did have often decreased bone mineral density as well as an increased risk of fractures. Since PRL control may be relevant to bone health it is a clinical open issue the inclusion of skeletal health in future guidelines as indication to proactive screening, prevention and treatment particularly in high risk patients such as hyperprolactinemic women after menopause and patients with drug induced hyperprolactinemia.
Filiaciones:
di Filippo, L:
San Raffaele Vita Salute Univ, IRCCS San Raffaele Hosp, Div Endocrinol, Via Olgettina 58, I-20132 Milan, Italy
Doga, M:
San Raffaele Vita Salute Univ, IRCCS San Raffaele Hosp, Div Endocrinol, Via Olgettina 58, I-20132 Milan, Italy
Resmini, E:
Hosp Santa Creu & Sant Pau, Dept Endocrinol, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Dept Med, Barcelona, Spain
Giustina, A:
San Raffaele Vita Salute Univ, IRCCS San Raffaele Hosp, Div Endocrinol, Via Olgettina 58, I-20132 Milan, Italy
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