Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
Por:
Baeza, I, de la Serna, E, Mezquida, G, Cuesta, MJ, Vieta, E, Amoretti, S, Lobo, A, González-Pinto, A, Díaz-Caneja, CM, Corripio, I, Valli, I, Puig, O, Mané, A, Bioque, M, Ayora, M, Bernardo, M, Castro-Fornieles, J
Publicada:
1 mar 2024
Ahead of Print:
1 abr 2023
Resumen:
To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 +/- 5.1 years; 66.5% male) and 58 EOP patients (15.5 +/- 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.
Filiaciones:
Baeza, I:
Hosp Clin Barcelona, Child & Adolescent Psychiat & Psychol Dept, 2021SGR01319, Barcelona, Spain
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
de la Serna, E:
Hosp Clin Barcelona, Child & Adolescent Psychiat & Psychol Dept, 2021SGR01319, Barcelona, Spain
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Mezquida, G:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Cuesta, MJ:
Navarra Inst Hlth Res, Dept Psychiat, Pamplona IdiSNA, Complejo Hosp Navarra, Pamplona, Spain
Vieta, E:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Bipolar & Depress Disorder Unit, Barcelona, Spain
Amoretti, S:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Bipolar & Depress Disorder Unit, Barcelona, Spain
Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat, Mental Hlth & Addict, Barcelona, Spain
Lobo, A:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Zaragoza, Hosp Clin Univ, Dept Med & Psychiat, Zaragoza, Spain
Univ Zaragoza, Inst Invest Sanitaria IIS Aragon, Zaragoza, Spain
González-Pinto, A:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Hosp Univ Alava, Dept Psychiat, BIOARABA, EHU, Vitoria, Spain
Díaz-Caneja, CM:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Sch Med,Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain
Corripio, I:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Autonoma Barcelona UAB, Hosp Santa Creu I Sant Pau, Inst Invest Biomed Sant Pau IIB St PAU, Psychiat Dept, Barcelona, Spain
Valli, I:
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Puig, O:
Hosp Clin Barcelona, Child & Adolescent Psychiat & Psychol Dept, 2021SGR01319, Barcelona, Spain
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
Mané, A:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Pompeu Fabra Univ, Hosp del Mar Med Res Inst IMIM, Barcelona, Spain
Bioque, M:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Ayora, M:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Hosp Univ Alava, Dept Psychiat, BIOARABA, EHU, Vitoria, Spain
Bernardo, M:
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Castro-Fornieles, J:
Hosp Clin Barcelona, Child & Adolescent Psychiat & Psychol Dept, 2021SGR01319, Barcelona, Spain
CIBERSAM ISCIII, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Inst Invest Biomed August Pi Sunyer CERCA IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Green Published, hybrid, All Open Access, Hybrid Gold, Green
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