Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
Por:
Aranha, MR, Iulita M.F., Montal V., Pegueroles J., Bejanin A., Vaqué-Alcázar L., Grothe M.J., Carmona-Iragui M., Videla L., Benejam B., Arranz J., Padilla C., Valldeneu S., Barroeta I., Altuna M., Fernández S., Ribas L., Valle-Tamayo N., Alcolea D., González-Ortiz S., Bargalló N., Zetterberg H., Blennow K., Blesa R., Wisniewski T., Busciglio J., Cuello A.C., Lleó A., Fortea J.
Publicada:
6 abr 2023
Ahead of Print:
1 abr 2023
Resumen:
BackgroundBasal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. MethodsWe included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. ResultsIn DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. DiscussionBF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.
Filiaciones:
Aranha, MR:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Iulita M.F.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Montal V.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Pegueroles J.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Bejanin A.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Vaqué-Alcázar L.:
Univ Barcelona, Inst Neurosci, Barcelona, Spain
Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Barcelona, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Grothe M.J.:
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Univ Seville, Hosp Univ Virgen Rocio, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin,Inst Biomed Sevill, Seville, Spain
Carmona-Iragui M.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Videla L.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Benejam B.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Arranz J.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Padilla C.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Valldeneu S.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Barroeta I.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Altuna M.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fernández S.:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Ribas L.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Valle-Tamayo N.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Alcolea D.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
González-Ortiz S.:
Hosp Mar Parc Salut Mar, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Bargalló N.:
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Magnet Resonance Image Core Facil IDIBAPS, Barcelona, Spain
Zetterberg H.:
UCL, Queen Sq Inst Neurol, London, England
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
UCL, UK Dementia Res Inst, London, England
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China
Blennow K.:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Blesa R.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Wisniewski T.:
NYU, Dept Neurol Pathol & Psychiat, Grossman Sch Med, New York, NY USA
NYU, Ctr Cognit Neurol, Grossman Sch Med, New York, NY USA
Busciglio J.:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders IMIND, Ctr Neurobiol Learning & Memory, Dept Neurobiol & Behav, Irvine, CA USA
Cuello A.C.:
McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada
McGill Univ, Dept Anat & Cell Biol, Montreal, PQ, Canada
Univ Oxford, Dept Pharmacol, Oxford, England
Lleó A.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fortea J.:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St PAU, Fac Med, St Pau Memory Unit,Dept Neurol,Hosp Santa Creu &, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Hosp Santa Creui St Pau, Neurol Dept, St Antoni Ma Claret 167, Barcelona 08025, Spain
hybrid, All Open Access; Hybrid Gold
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