Obstetric complications and clinical presentation in first episode of psychosis
Por:
Verdolini, N, Mezquida, G, Valli, I, Garcia-Rizo, C, Cuesta, M, Vieta, E, Bioque, M, Lobo, A, Gonzalez-Pinto, A, Pina-Camacho, L, Corripio, I, Garriga, M, Baeza, I, Martinez-Sadurni, L, Bitanihirwe, B, Cannon, M, Bernardo, M
Publicada:
2 mar 2023
Ahead of Print:
1 mar 2023
Resumen:
Objective:Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods:Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results:Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions:Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
Filiaciones:
Verdolini, N:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,DIBAPS,CIBERSAM, Barcelona, Spain
Mezquida, G:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci, Barcelona Clin Schizophrenia Unit,CIBERSAM,IDIBAP, Barcelona, Spain
Valli, I:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Child & Adolescent Psychiat & Psychol Dept,CIBERS, Barcelona, Spain
Garcia-Rizo, C:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci, Barcelona Clin Schizophrenia Unit,CIBERSAM,IDIBAP, Barcelona, Spain
Cuesta, M:
Navarre Hosp Complex, Navarre Inst Hlth Res, Dept Psychiat, IdiSNA, Pamplona, Spain
Vieta, E:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,DIBAPS,CIBERSAM, Barcelona, Spain
Bioque, M:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci, Barcelona Clin Schizophrenia Unit,CIBERSAM,IDIBAP, Barcelona, Spain
Lobo, A:
Univ Zaragoza, Dept Med & Psychiat, Madrid, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Madrid, Spain
CIBERSAM, Madrid, Spain
Gonzalez-Pinto, A:
Univ Basque Country, Hosp Univ Alava, Serv Psiquiatria, BIOARABA,CIBERSAM, Leioa, Spain
Pina-Camacho, L:
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat, IiSGM,Sch Med,Inst Psychiat & Mental Hlth,CIBERS, Madrid, Spain
Corripio, I:
Hosp Santa Creu & Sant Pau, Dept Psychiat, CIBERSAM, Barcelona, Spain
Garriga, M:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,DIBAPS,CIBERSAM, Barcelona, Spain
Baeza, I:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Child & Adolescent Psychiat & Psychol Dept,CIBERS, Barcelona, Spain
Martinez-Sadurni, L:
Autonomous Univ Barcelona, Hosp Mar Med Res Inst IMIM, CIBERSAM, Barcelona, Spain
Bitanihirwe, B:
Univ Manchester, Humanitarian & Conflict Response Inst, Manchester, England
Bernardo, M:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci, Barcelona Clin Schizophrenia Unit,CIBERSAM,IDIBAP, Barcelona, Spain
RCSI Univ Med & Hlth Sci, Dept Psychiat, Dublin, Ireland
Green Published, hybrid
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