Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease
Por:
Santos-Garcia, D, Laguna, A, Hernandez-Vara, J, Fonticoba, TD, Bartolome, CC, Painceiras, MJF, Iniguez-Alvarado, MC, Diaz, IG, Jesus, S, Boungiorno, MT, Planellas, L, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Mayordomo, VG, Nogueira, V, Puente, V, Garcia-Soto, JD, Borrue, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Padilla, FC, Castrillo, JCM, Alonso, PS, Losada, MGA, Ariztegui, NL, Gaston, I, Kulisevsky, J, Gonzalez, MM, Seijo, M, Martinez, JR, Valero, C, Kurtis, M, Ardura, JG, Redondo, RA, Ordas, C, Diaz, LML, McAfee, D, Martinez-Martin, P, Mir, P
Publicada:
1 feb 2023
Ahead of Print:
7 feb 2023
Resumen:
Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
Filiaciones:
Santos-Garcia, D:
CHUAC Complejo Hosp Univ A Coruna, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Laguna, A:
Vall dHebron Res Inst VHIR, Neurodegenerat Dis Res Grp, Barcelona 08035, Spain
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Hernandez-Vara, J:
Vall dHebron Res Inst VHIR, Neurodegenerat Dis Res Grp, Barcelona 08035, Spain
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Fonticoba, TD:
CHUF Complejo Hosp Univ Ferrol, Ferrol 15405, Spain
Bartolome, CC:
CHUAC Complejo Hosp Univ A Coruna, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Painceiras, MJF:
CHUAC Complejo Hosp Univ A Coruna, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Iniguez-Alvarado, MC:
CHUAC Complejo Hosp Univ A Coruna, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Diaz, IG:
CHUAC Complejo Hosp Univ A Coruna, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Jesus, S:
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Serv Neurol & Neurofisiol Clin,CSIC,Unidad Trasto, Seville 41013, Spain
Boungiorno, MT:
Hosp Univ Mutua Terrassa, Terrassa 08221, Spain
Planellas, L:
Clin Pilar, Barcelona 50006, Spain
Cosgaya, M:
Hosp Clin Barcelona, Barcelona 08036, Spain
Caldentey, JG:
Ctr Neurol, Oms 42, Palma De Mallorca 07003, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanit Integral, Sant Joan Despi 08970, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca 07120, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra 36001, Spain
Manzanares, LL:
Hosp Univ La Princesa, Madrid 28006, Spain
Aramburu, IG:
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Hosp Univ Marques de Valdecilla, Santander 39008, Spain
Rivera, MAA:
Hosp Gen LHospitalet, Consorci Sanit Integral, Lhospitalet De Llobregat 08906, Barcelona, Spain
Mayordomo, VG:
Hosp Univ Clin San Carlos, Madrid 28040, Spain
Nogueira, V:
Hosp Costa, Burela 27880, Spain
Puente, V:
Hosp Mar, Barcelona 08003, Spain
Garcia-Soto, JD:
Hosp Univ Virgen Macarena, Seville 41009, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid 28702, Spain
Vila, BS:
Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona 17190, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche 03203, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid 28922, Spain
Escalante, S:
Hosp Tortosa Verge Cinta HTVC, Tortosa 43500, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos 09006, Spain
Padilla, FC:
Hosp Univ Canarias, San Cristobal De La Lagu 38320, Spain
Castrillo, JCM:
Hosp Univ Ramon & Cajal, IRYCIS, Madrid 28034, Spain
Alonso, PS:
Hosp Univ Puerta de Hierro, Madrid 28222, Spain
Losada, MGA:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo 36312, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo 45007, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona 31008, Spain
Kulisevsky, J:
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Hosp Sant Pau, Barcelona 08025, Spain
Gonzalez, MM:
Hosp Univ Cent Asturias, Oviedo 33011, Spain
Martinez, JR:
Hosp Univ Donostia, Donostia San Sebastian 20014, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia 25198, Spain
Kurtis, M:
Hosp Ruber Int, Madrid 28034, Spain
Ardura, JG:
Hosp Cabuenes, Gijon 33394, Spain
Redondo, RA:
Univ Lucus Augusti HULA, Lugo 27003, Spain
Ordas, C:
Hosp Rey Juan Carlos, Madrid 28933, Spain
Diaz, LML:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo 36312, Spain
McAfee, D:
Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA
Martinez-Martin, P:
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Mir, P:
CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid 19171, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Serv Neurol & Neurofisiol Clin,CSIC,Unidad Trasto, Seville 41013, Spain
gold, Green Accepted, All Open Access, Gold, Green
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