Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis
Por:
Puig, N, Camps-Renom, P, Sole, A, Aguilera-Simon, A, Jimenez-Xarrie, E, Fernandez-Leon, A, Camacho, M, Guasch-Jimenez, M, Marin, R, Marti-Fabregas, J, Martinez-Domeno, A, Prats-Sanchez, L, Casoni, F, Perez, B, Jimenez-Altayo, F, Sanchez-Quesada, JL, Benitez, S
Publicada:
10 feb 2023
Ahead of Print:
10 feb 2023
Resumen:
Owing to the high risk of recurrence, identifying indicators of carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in plasma from patients with a recent ischemic stroke and carotid atherosclerosis. Patients underwent an ultrasound, a CT-angiography, and an F-18-FDG PET. A blood sample was obtained from patients (n = 64, 57.8% with stenosis >= 50%) and healthy controls (n = 24). Compared to the controls, patients showed lower levels of total cholesterol, LDL cholesterol, HDL cholesterol, apolipoprotein B (apoB), apoA-I, apoA-II, and apoE, and higher levels of apoJ. Patients showed lower platelet-activating factor acetylhydrolase (PAF-AH) and paraoxonase-1 (PON-1) enzymatic activities in HDL, and higher plasma levels of oxidized LDL (oxLDL) and electronegative LDL (LDL(-)). The only difference between patients with stenosis >= 50% and <50% was the proportion of LDL(-). In a multivariable logistic regression analysis, the levels of LDL(-), but not of oxLDL, were independently associated with the degree of carotid stenosis (OR: 5.40, CI: 1.15-25.44, p < 0.033), the presence of hypoechoic plaque (OR: 7.52, CI: 1.26-44.83, p < 0.027), and of diffuse neovessels (OR: 10.77, CI: 1.21-95.93, p < 0.033), indicating that an increased proportion of LDL(-) is associated with vulnerable atherosclerotic plaque.
Filiaciones:
Puig, N:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Fac Med, Dept Biochem & Mol Biol, Barcelona 08193, Spain
Camps-Renom, P:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Sole, A:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Fac Med, Dept Biochem & Mol Biol, Barcelona 08193, Spain
Aguilera-Simon, A:
Univ Autonoma Barcelona, Fac Med, Dept Biochem & Mol Biol, Barcelona 08193, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Jimenez-Xarrie, E:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Fernandez-Leon, A:
Hosp Santa Creu & Sant Pau, Dept Nucl Med, IIB St Pau, Barcelona 08041, Spain
Camacho, M:
Inst Invest Biomed St Pau IIB St Pau, Genet Complexes Dis, Barcelona 08041, Spain
Guasch-Jimenez, M:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Marin, R:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Marti-Fabregas, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Martinez-Domeno, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Prats-Sanchez, L:
Hosp Santa Creu & Sant Pau, Dept Neurol, Stroke Unit, IIB St Pau, Barcelona 08041, Spain
Casoni, F:
IRCCS San Raffaele Sci Inst, Neurol Sleep Disorders Ctr, Dept Clin Neurosci, I-20132 Milan, Italy
Perez, B:
Univ Autonoma Barcelona, Sch Med, Dept Pharmacol, Therapeut & Toxicol, Barcelona 08193, Spain
Univ Autonoma Barcelona, Neurosci Inst, Barcelona 08193, Spain
Jimenez-Altayo, F:
Univ Autonoma Barcelona, Sch Med, Dept Pharmacol, Therapeut & Toxicol, Barcelona 08193, Spain
Univ Autonoma Barcelona, Neurosci Inst, Barcelona 08193, Spain
Sanchez-Quesada, JL:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Biochem, Barcelona 08041, Spain
Inst Salud Carlos III, CIBER Diabet & Metab Dis CIBERDEM, Madrid 28029, Spain
Benitez, S:
Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Biochem, Barcelona 08041, Spain
Inst Salud Carlos III, CIBER Diabet & Metab Dis CIBERDEM, Madrid 28029, Spain
Green Published, gold, All Open Access, Gold, Green
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