Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis


Por: Kanoni S., Graham S.E., Wang Y., Surakka I., Ramdas S., Clarke S.L., Bhatti K.F., Vedantam S., Winkler T.W., Locke A.E., Marouli E., Zajac G.J.M., Wu K.-H.H., Ntalla I., Hui Q., Klarin D., Hilliard A.T., Xue C., Thorleifsson G., Helgadottir A., Gudbjartsson D.F., Holm H., Olafsson I., Hwang M.Y., Han S., Akiyama M., Sakaue S., Terao C., Kanai M., Zhou W., Brumpton B.M., Rasheed H., Havulinna A.S., Veturi Y., Pacheco J.A., Rosenthal E.A., Lingren T., Feng Q.P., Kullo I.J., Narita A., Takayama J., Martin H.C., Hunt K.A., Trivedi B., Haessler J., Giulianini F., Bradford Y., Miller J.E., Campbell A., Lin K., Millwood I.Y., Rasheed A., Hindy G., Faul J.D., Zhao W., Weir D.R., Turman C., Huang H., Graff M., Choudhury A., Sengupta D., Mahajan A., Brown M.R., Zhang W., Yu K., Schmidt E.M., Pandit A., Gustafsson S., Yin X., Luan J., Zhao J.-H., Matsuda F., Jang H.-M., Yoon K., Medina-Gomez C., Pitsillides A., Hottenga J.J., Wood A.R., Ji Y., Gao Z., Haworth S., Yousri N.A., Mitchell R.E., Chai J.F., Aadahl M., Bjerregaard A.A., Yao J., Manichaikul A., Hwu C.-M., Hung Y.-J., Warren H.R., Ramirez J., Bork-Jensen J., Kårhus L.L., Goel A., Sabater-Lleal M., Noordam R., Mauro P., Matteo F., McDaid A.F., Marques-Vidal P., Wielscher M., Trompet S., Sattar N., Møllehave L.T., Munz M., Zeng L., Huang J., Yang B., Poveda A., Kurbasic A., Lamina C., Forer L., Scholz M., Galesloot T.E., Bradfield J.P., Ruotsalainen S.E., Daw E.W., Zmuda J.M., Mitchell J.S., Fuchsberger C., Christensen H., Brody J.A., Vazquez-Moreno M., Feitosa M.F., Wojczynski M.K., Wang Z., Preuss M.H., Mangino M., Christofidou P., Verweij N., Benjamins J.W., Engmann J., Tsao N.L., Verma A., Slieker R.C., Lo K.S., Zilhao N.R., Le P., Kleber M.E., Delgado G.E., Huo S., Ikeda D.D., Iha H., Demirkan A., Leonard H.L., Marten J., Frank M., Schmidt B., Smyth L.J., Cañadas-Garre M., Wang C., Nakatochi M., Wong A., Hutri-Kähönen N., Sim X., Xia R., Huerta-Chagoya A., Fernandez-Lopez J.C., Lyssenko V., Nongmaithem S.S., Bayyana S., Stringham H.M., Irvin M.R., Oldmeadow C., Kim H.-N., Ryu S., Timmers P.R.H.J., Arbeeva L., Dorajoo R., Lange L.A., Prasad G., Lorés-Motta L., Pauper M., Long J., Theusch E., Takeuchi F., Spracklen C.N., Loukola A., Bollepalli S., Warner S.C., Wang Y.X., Wei W.B., Nutile T., Ruggiero D., Sung Y.J., Chen S., Liu F., Yang J., Kentistou K.A., Banas B., Nardone G.G., Meidtner K., Bielak L.F., Smith J.A., Hebbar P., Farmaki A.-E., Hofer E., Lin M., Concas M.P., Vaccargiu S., van der Most P.J., Pitkänen N., Cade B.E., van der Laan S.W., Chitrala K.N., Weiss S., Bentley A.R., Doumatey A.P., Adeyemo A.A., Lee J.Y., Petersen E.R.B., Nielsen A.A., Choi H.S., Nethander M., Freitag-Wolf S., Southam L., Rayner N.W., Wang C.A., Lin S.-Y., Wang J.-S., Couture C., Lyytikäinen L.-P., Nikus K., Cuellar-Partida G., Vestergaard H., Hidalgo B., Giannakopoulou O., Cai Q., Obura M.O., van Setten J., Li X., Liang J., Tang H., Terzikhan N., Shin J.H., Jackson R.D., Reiner A.P., Martin L.W., Chen Z., Li L., Kawaguchi T., Thiery J., Bis J.C., Launer L.J., Nalls M.A., Raitakari O.T., Ichihara S., Wild S.H., Nelson C.P., Campbell H., Jäger S., Nabika T., Al-Mulla F., Niinikoski H., Braund P.S., Kolcic I., Kovacs P., Giardoglou T., Katsuya T., de Kleijn D., de Borst G.J., Kim E.K., Adams H.H.H., Ikram M.A., Zhu X., Asselbergs F.W., Kraaijeveld A.O., Beulens J.W.J., Shu X.-O., Rallidis L.S., Pedersen O., Hansen T., Mitchell P., Hewitt A.W., Kähönen M., Pérusse L., Bouchard C., Tönjes A., Chen Y.-D.I., Pennell C.E., Mori T.A., Lieb W., Franke A., Ohlsson C., Mellström D., Cho Y.S., Lee H., Yuan J.-M., Koh W.-P., Rhee S.Y., Woo J.-T., Heid I.M., Stark K.J., Zimmermann M.E., Völzke H., Homuth G., Evans M.K., Zonderman A.B., Polasek O., Pasterkamp G., Hoefer I.E., Redline S., Pahkala K., Oldehinkel A.J., Snieder H., Biino G., Schmidt R., Schmidt H., Bandinelli S., Dedoussis G., Thanaraj T.A., Kardia S.L.R., Peyser P.A., Kato N., Schulze M.B., Girotto G., Böger C.A., Jung B., Joshi P.K., Bennett D.A., De Jager P.L., Lu X., Mamakou V., Brown M., Caulfield M.J., Munroe P.B., Guo X., Ciullo M., Jonas J.B., Samani N.J., Kaprio J., Pajukanta P., Tusié-Luna T., Aguilar-Salinas C.A., Adair L.S., Bechayda S.A., de Silva H.J., Wickremasinghe A.R., Krauss R.M., Wu J.-Y., Zheng W., Hollander A.I., Bharadwaj D., Correa A., Wilson J.G., Lind L., Heng C.-K., Nelson A.E., Golightly Y.M., Wilson J.F., Penninx B., Kim H.-L., Attia J., Scott R.J., Rao D.C., Arnett D.K., Hunt S.C., Walker M., Koistinen H.A., Chandak G.R., Mercader J.M., Costanzo M.C., Jang D., Burtt N.P., Villalpando C.G., Orozco L., Fornage M., Tai E.S., van Dam R.M., Lehtimäki T., Chaturvedi N., Yokota M., Liu J., Reilly D.F., McKnight A.J., Kee F., Jöckel K.-H., McCarthy M.I., Palmer C.N.A., Vitart V., Hayward C., Simonsick E., van Duijn C.M., Jin Z.-B., Qu J., Hishigaki H., Lin X., März W., Gudnason V., Tardif J.-C., Lettre G., Hart L.M., Elders P.J.M., Damrauer S.M., Kumari M., Kivimaki M., van der Harst P., Spector T.D., Loos R.J.F., Province M.A., Parra E.J., Cruz M., Psaty B.M., Brandslund I., Pramstaller P.P., Rotimi C.N., Christensen K., Ripatti S., Widén E., Hakonarson H., Grant S.F.A., Kiemeney L.A.L.M., de Graaf J., Loeffler M., Kronenberg F., Gu D., Erdmann J., Schunkert H., Franks P.W., Linneberg A., Jukema J.W., Khera A.V., Männikkö M., Jarvelin M.-R., Kutalik Z., Francesco C., Mook-Kanamori D.O., van Dijk K.W., Watkins H., Strachan D.P., Grarup N., Sever P., Poulter N., Chuang L.-M., Rotter J.I., Dantoft T.M., Karpe F., Neville M.J., Timpson N.J., Cheng C.-Y., Wong T.-Y., Khor C.C., Li H., Sabanayagam C., Peters A., Gieger C., Hattersley A.T., Pedersen N.L., Magnusson P.K.E., Boomsma D.I., Willemsen A.H.M., Cupples L.A., van Meurs J.B.J., Ghanbari M., Gordon-Larsen P., Huang W., Kim Y.J., Tabara Y., Wareham N.J., Langenberg C., Zeggini E., Kuusisto J., Laakso M., Ingelsson E., Abecasis G., Chambers J.C., Kooner J.S., de Vries P.S., Morrison A.C., Hazelhurst S., Ramsay M., North K.E., Daviglus M., Kraft P., Martin N.G., Whitfield J.B., Abbas S., Saleheen D., Walters R.G., Holmes M.V., Black C., Smith B.H., Baras A., Justice A.E., Buring J.E., Ridker P.M., Chasman D.I., Kooperberg C., Tamiya G., Yamamoto M., van Heel D.A., Trembath R.C., Wei W.-Q., Jarvik G.P., Namjou B., Hayes M.G., Ritchie M.D., Jousilahti P., Salomaa V., Hveem K., Åsvold B.O., Kubo M., Kamatani Y., Okada Y., Murakami Y., Kim B.-J., Thorsteinsdottir U., Stefansson K., Zhang J., Chen Y.E., Ho Y.-L., Lynch J.A., Rader D.J., Tsao P.S., Chang K.-M., Cho K., O’Donnell C.J., Gaziano J.M., Wilson P.W.F., Frayling T.M., Hirschhorn J.N., Kathiresan S., Mohlke K.L., Sun Y.V., Morris A.P., Boehnke M., Brown C.D., Natarajan P., Deloukas P., Willer C.J., Assimes T.L., Peloso G.M.

Publicada: 1 ene 2022
Resumen:
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk. © 2022, The Author(s).

Filiaciones:
Kanoni S.:
 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Graham S.E.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

Wang Y.:
 Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA 02118, United States

Surakka I.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

Ramdas S.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

Clarke S.L.:
 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States

Bhatti K.F.:
 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Vedantam S.:
 Boston Children’s Hospital, EndocrinologyBoston, MA 02115, United States

 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

Winkler T.W.:
 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

Locke A.E.:
 McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO 63108, United States

Marouli E.:
 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Zajac G.J.M.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Wu K.-H.H.:
 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States

Ntalla I.:
 Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom

Hui Q.:
 Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States

 Atlanta VA Health Care System, Decatur, GA, United States

Klarin D.:
 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

 Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States

Hilliard A.T.:
 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

Xue C.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

Thorleifsson G.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

Helgadottir A.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

Gudbjartsson D.F.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

 School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland

Holm H.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

Olafsson I.:
 Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik, 101, Iceland

Hwang M.Y.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Han S.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Akiyama M.:
 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Sakaue S.:
 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan

 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Terao C.:
 Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Kanai M.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States

Zhou W.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States

 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States

Brumpton B.M.:
 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

 MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

 Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Rasheed H.:
 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

 MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

 Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway

Havulinna A.S.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

 Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland

Veturi Y.:
 Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, United States

Pacheco J.A.:
 Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60618, United States

Rosenthal E.A.:
 Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, United States

Lingren T.:
 Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States

Feng Q.P.:
 Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States

Kullo I.J.:
 Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States

Narita A.:
 Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan

Takayama J.:
 Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan

Martin H.C.:
 Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

Hunt K.A.:
 Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Trivedi B.:
 Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Haessler J.:
 Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA 9810, United States

Giulianini F.:
 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, United States

Bradford Y.:
 Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, United States

Miller J.E.:
 Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, United States

Campbell A.:
 Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, United Kingdom

 Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, EH16 4UX, United Kingdom

Lin K.:
 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

Millwood I.Y.:
 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

Rasheed A.:
 Center for Non-Communicable Diseases, Sindh, Karachi, Pakistan

Hindy G.:
 Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar

Faul J.D.:
 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, United States

Zhao W.:
 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, United States

 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States

Weir D.R.:
 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, United States

Turman C.:
 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States

Huang H.:
 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States

Graff M.:
 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States

Choudhury A.:
 Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Sengupta D.:
 Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Mahajan A.:
 Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom

Brown M.R.:
 Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Zhang W.:
 Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, United Kingdom

 Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, United Kingdom

Yu K.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Schmidt E.M.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Pandit A.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Gustafsson S.:
 Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Yin X.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Luan J.:
 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, United Kingdom

Zhao J.-H.:
 Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway, Cambridge, CB1 8RN, United Kingdom

Matsuda F.:
 Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Jang H.-M.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Yoon K.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Medina-Gomez C.:
 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Pitsillides A.:
 Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA 02118, United States

Hottenga J.J.:
 Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

 Amsterdam Public Health Research Institute, Amsterdam UMC, Netherlands

Wood A.R.:
 Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, United Kingdom

Ji Y.:
 Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, United Kingdom

Gao Z.:
 Nanjing University of Chinese Medicine, Jiangsu, Nanjing, 210029, China

 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Haworth S.:
 MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

 Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom

Yousri N.A.:
 Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

 Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt

Mitchell R.E.:
 MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

 Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

Chai J.F.:
 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore

Aadahl M.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Bjerregaard A.A.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Yao J.:
 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, United States

Manichaikul A.:
 Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, United States

Hwu C.-M.:
 Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

Hung Y.-J.:
 Institute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan

Warren H.R.:
 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom

 NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom

Ramirez J.:
 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom

 Aragon Institute of Engineering Research, University of Zaragoza and Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales Y Nanomedicina, Spain

Bork-Jensen J.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Kårhus L.L.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Goel A.:
 Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom

 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom

Sabater-Lleal M.:
 Unit of Genomics of Complex Diseases, Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain

 Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

Noordam R.:
 Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

Mauro P.:
 Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy

Matteo F.:
 Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy

 Dipartimento Di Scienze Biomediche, Università Degli Studi Di Sassari, Sardinia, Italy

McDaid A.F.:
 University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, Lausanne, 1010, Switzerland

 Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland

Marques-Vidal P.:
 Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland

Wielscher M.:
 Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom

Trompet S.:
 Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands

 Dept of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

Sattar N.:
 BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom

Møllehave L.T.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Munz M.:
 Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité – University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany

Zeng L.:
 Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany

 Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany

Huang J.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

Yang B.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

Poveda A.:
 Lund University Diabetes Center, Lund University, Malmö, Sweden

Kurbasic A.:
 Lund University Diabetes Center, Lund University, Malmö, Sweden

Lamina C.:
 Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria

 German Chronic Kidney Disease Study, Berlin, Germany

Forer L.:
 Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria

 German Chronic Kidney Disease Study, Berlin, Germany

Scholz M.:
 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, Leipzig, 04107, Germany

 LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, Leipzig, 04103, Germany

Galesloot T.E.:
 Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands

Bradfield J.P.:
 Quantinuum Research LLC, Wayne, PA 19087, United States

Ruotsalainen S.E.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

Daw E.W.:
 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States

Zmuda J.M.:
 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States

Mitchell J.S.:
 Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, Bolzano, 39100, Italy

Fuchsberger C.:
 Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, Bolzano, 39100, Italy

Christensen H.:
 Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark

Brody J.A.:
 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, United States

Vazquez-Moreno M.:
 Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico

Feitosa M.F.:
 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States

Wojczynski M.K.:
 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States

Wang Z.:
 Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States

 Atlanta VA Health Care System, Decatur, GA, United States

Preuss M.H.:
 The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Mangino M.:
 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom

 NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, SE1 9RT, United Kingdom

Christofidou P.:
 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom

Verweij N.:
 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

Benjamins J.W.:
 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

Engmann J.:
 Institute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom

 Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, United Kingdom

Tsao N.L.:
 Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States

Verma A.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

Slieker R.C.:
 Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, Netherlands

 Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands

Lo K.S.:
 Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ H1T1C8, Canada

Zilhao N.R.:
 Icelandic Heart Association, Kopavogur, 201, Iceland

Le P.:
 Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada

Kleber M.E.:
 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany

 SYNLAB MVZ Humangenetik Mannheim GmbH, Mannheim, 68163, Germany

Delgado G.E.:
 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany

Huo S.:
 Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Ikeda D.D.:
 Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

Iha H.:
 Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

Demirkan A.:
 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

 Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Surrey, Guildford, United Kingdom

Leonard H.L.:
 Laboratory of Neurogenetics, National Institute On Aging, NIH, Bethesda, MD, United States

 Data Tecnica International, Glen Echo, MD, United States

Marten J.:
 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom

Frank M.:
 Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

Schmidt B.:
 Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

Smyth L.J.:
 Centre for Public Health, Queen’s University of Belfast, Belfast, United Kingdom

Cañadas-Garre M.:
 Centre for Public Health, Queen’s University of Belfast, Belfast, United Kingdom

 Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain

 Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain

 Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain

Wang C.:
 Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

 Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

Nakatochi M.:
 Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan

Wong A.:
 MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, United Kingdom

Hutri-Kähönen N.:
 Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

Sim X.:
 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore

Xia R.:
 Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Huerta-Chagoya A.:
 CONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico

 Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States

 Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, Mexico City, 04510, Mexico

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Fernandez-Lopez J.C.:
 Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico

Lyssenko V.:
 Lund University Diabetes Center, Lund University, Malmö, Sweden

 Center for Diabetes Research, University of Bergen, Bergen, Norway

Nongmaithem S.S.:
 Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

Bayyana S.:
 Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Telangana, Hyderabad, India

 Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

Stringham H.M.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Irvin M.R.:
 Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States

Oldmeadow C.:
 Hunter Medical Research Institute, Newcastle, Australia

Kim H.-N.:
 Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, South Korea

 Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, South Korea

Ryu S.:
 Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, South Korea

 Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, South Korea

Timmers P.R.H.J.:
 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom

 Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Arbeeva L.:
 Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States

Dorajoo R.:
 Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

 Duke-NUS Medical School, Health Services and Systems Research, Singapore, 169857, Singapore

Lange L.A.:
 Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Denver, Aurora, CO 80045, United States

Prasad G.:
 Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India

 Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Uttar Pradesh, Ghaziabad, India

Lorés-Motta L.:
 Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, Netherlands

Pauper M.:
 Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, Netherlands

Long J.:
 Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, United States

Theusch E.:
 Department of Pediatrics, University of California San Francisco, Oakland, CA 94609, United States

Takeuchi F.:
 National Center for Global Health and Medicine, Tokyo, 1628655, Japan

Spracklen C.N.:
 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States

 Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA 01003, United States

Loukola A.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

Bollepalli S.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

Warner S.C.:
 Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

 NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Wang Y.X.:
 Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China

Wei W.B.:
 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, China

Nutile T.:
 Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR, Naples, Italy

Ruggiero D.:
 Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR, Naples, Italy

 IRCCS Neuromed, Isernia, Pozzilli, Italy

Sung Y.J.:
 Division of Biostatistics, Washington University, St. Louis, MO 63110, United States

Chen S.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

Liu F.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

Yang J.:
 School of Life Sciences, Westlake University, Zhejiang, Hangzhou, 310024, China

 Westlake Laboratory of Life Sciences and Biomedicine, Zhejiang, Hangzhou, 310024, China

 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

Kentistou K.A.:
 Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Banas B.:
 Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany

Nardone G.G.:
 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

Meidtner K.:
 Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

 German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

Bielak L.F.:
 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States

Smith J.A.:
 Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, United States

 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States

Hebbar P.:
 Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait

Farmaki A.-E.:
 Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece

 Department of Clinical Epidemiology, Institute of Health Informatics, University College London, London, United Kingdom

Hofer E.:
 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria

 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria

Lin M.:
 Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, United States

Concas M.P.:
 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

Vaccargiu S.:
 Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy

van der Most P.J.:
 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands

Pitkänen N.:
 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

 Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland

Cade B.E.:
 Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, United States

 Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, United States

 Harvard Medical School, Boston, MA 02115, United States

van der Laan S.W.:
 Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Chitrala K.N.:
 Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD 20892-9205, United States

 Department of Engineering Technology, University of Houston-Sugarland, Houston, TX, United States

Weiss S.:
 Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany

Bentley A.R.:
 Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD 20892, United States

Doumatey A.P.:
 Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD 20892, United States

Adeyemo A.A.:
 Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD 20892, United States

Lee J.Y.:
 Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, South Korea

Petersen E.R.B.:
 Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, Aabenraa, 6200, Denmark

Nielsen A.A.:
 Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark

Choi H.S.:
 Department of Biomedical Science, Hallym University, Gangwon-Do, Chuncheon, 24252, South Korea

Nethander M.:
 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

 Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Freitag-Wolf S.:
 Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany

Southam L.:
 Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

 Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

Rayner N.W.:
 Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

 Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom

 Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

Wang C.A.:
 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia

Lin S.-Y.:
 Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

 School of Medicine, National Yang-Ming University, Taipei, Taiwan

 School of Medicine, National Defense Medical Center, Taipei, Taiwan

 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

Wang J.-S.:
 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

 Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

Couture C.:
 Department of Kinesiology, Université Laval, Québec, Canada

Lyytikäinen L.-P.:
 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland

 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland

Nikus K.:
 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland

 Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland

Cuellar-Partida G.:
 University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD 4102, Australia

Vestergaard H.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

 Department of Medicine, Bornholms Hospital, Rønne, Denmark

Hidalgo B.:
 Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States

Giannakopoulou O.:
 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Cai Q.:
 Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, United States

Obura M.O.:
 Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, Netherlands

van Setten J.:
 Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Li X.:
 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, United States

Liang J.:
 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, United States

Tang H.:
 Department of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA 94305, United States

Terzikhan N.:
 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Shin J.H.:
 Department of Biomedical Science, Hallym University, Gangwon-Do, Chuncheon, 24252, South Korea

Jackson R.D.:
 Division of Endocrinology, Ohio State University, Columbus, OH 43210, United States

Reiner A.P.:
 Department of Epidemiology, University of Washington, Seattle, WA 98195, United States

Martin L.W.:
 School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, United States

Chen Z.:
 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

Li L.:
 Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China

Kawaguchi T.:
 Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Thiery J.:
 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, Leipzig, 04107, Germany

 Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, Leipzig, 04103, Germany

Bis J.C.:
 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, United States

Launer L.J.:
 Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD 20892-9205, United States

Nalls M.A.:
 Center for Alzheimer’s and Related Dementias, NIH, Bethesda, MD, United States

 Data Tecnica International, Washington, DC, United States

Raitakari O.T.:
 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

 Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland

 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

Ichihara S.:
 Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan

Wild S.H.:
 Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Nelson C.P.:
 Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

 NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Campbell H.:
 Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Jäger S.:
 Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

 German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

Nabika T.:
 Department of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan

Al-Mulla F.:
 Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait

Niinikoski H.:
 Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland

 Department of Physiology, University of Turku, Turku, Finland

Braund P.S.:
 Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

 NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Kolcic I.:
 University of Split School of Medicine, Šoltanska 2, Split, HR-21000, Croatia

Kovacs P.:
 University of Leipzig Medical Center, Liebigstr. 18, Medical Department III – Endocrinology, Nephrology, RheumatologyLeipzig, 04103, Germany

Giardoglou T.:
 Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, Athens, 17676, Greece

Katsuya T.:
 Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 5650871, Japan

 Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 5650871, Japan

de Kleijn D.:
 Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

de Borst G.J.:
 Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Kim E.K.:
 Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, South Korea

Adams H.H.H.:
 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

 Dept of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

 Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile

Ikram M.A.:
 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Zhu X.:
 Department of Statistics, The Pennsylvania State University, University Park, PA, United States

 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, United States

 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

 Department of Statistics, Stanford University, Stanford, CA, United States

Asselbergs F.W.:
 Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Kraaijeveld A.O.:
 Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Beulens J.W.J.:
 Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, Netherlands

 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, 3584CG, Netherlands

Shu X.-O.:
 Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, United States

Rallidis L.S.:
 Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece

Pedersen O.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Hansen T.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Mitchell P.:
 Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW 2145, Australia

Hewitt A.W.:
 School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Liverpool St, Hobart, TAS 7000, Australia

 Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC 3002, Australia

Kähönen M.:
 Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland

 Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland

Pérusse L.:
 Department of Kinesiology, Université Laval, Québec, Canada

 Centre Nutrition, Santé Et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Québec, Canada

Bouchard C.:
 Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States

Tönjes A.:
 University of Leipzig Medical Center, Liebigstr. 18, Medical Department III – Endocrinology, Nephrology, RheumatologyLeipzig, 04103, Germany

Chen Y.-D.I.:
 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, United States

Pennell C.E.:
 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia

Mori T.A.:
 Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia

Lieb W.:
 Institute of Epidemiology, Kiel University, Kiel, Germany

Franke A.:
 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany

Ohlsson C.:
 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

 Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden

Mellström D.:
 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

 Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Cho Y.S.:
 Department of Biomedical Science, Hallym University, Gangwon-Do, Chuncheon, 24252, South Korea

Lee H.:
 Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, South Korea

Yuan J.-M.:
 Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, United States

 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, United States

Koh W.-P.:
 Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore

 Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore

Rhee S.Y.:
 Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, South Korea

Woo J.-T.:
 Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, South Korea

Heid I.M.:
 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

Stark K.J.:
 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

Zimmermann M.E.:
 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

Völzke H.:
 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

Homuth G.:
 Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany

Evans M.K.:
 Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD 21224, United States

Zonderman A.B.:
 Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD 21224, United States

Polasek O.:
 University of Split School of Medicine, Šoltanska 2, Split, HR-21000, Croatia

 Algebra University College, Ilica 242, Zagreb, Croatia

Pasterkamp G.:
 Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Hoefer I.E.:
 Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Redline S.:
 Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, United States

 Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, United States

 Harvard Medical School, Boston, MA 02115, United States

Pahkala K.:
 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

 Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland

 Department of Physical Activity and Health, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, University of Turku, Turku, Finland

Oldehinkel A.J.:
 Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands

Snieder H.:
 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands

Biino G.:
 Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy

Schmidt R.:
 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria

Schmidt H.:
 Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria

Bandinelli S.:
 Local Health Unit Toscana Centro, Florence, Italy

Dedoussis G.:
 Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece

Thanaraj T.A.:
 Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait

Kardia S.L.R.:
 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States

Peyser P.A.:
 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States

Kato N.:
 National Center for Global Health and Medicine, Tokyo, 1628655, Japan

Schulze M.B.:
 Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

 German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

 Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

Girotto G.:
 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

 Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada Di Fiume 447, Trieste, 34149, Italy

Böger C.A.:
 Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany

 Department of Nephrology, Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany

 KfH Kidney Center Traunstein, Traunstein, Germany

Jung B.:
 Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany

 Department of Nephrology, Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany

 KfH Kidney Center Traunstein, Traunstein, Germany

Joshi P.K.:
 Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Bennett D.A.:
 Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

 Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States

De Jager P.L.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center, New York, NY, United States

Lu X.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

Mamakou V.:
 Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, Athens, 115 27, Greece

 Dromokaiteio Psychiatric Hospital, Athens, 124 61, Greece

Brown M.:
 Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Caulfield M.J.:
 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom

 NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom

Munroe P.B.:
 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, United Kingdom

 NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom

Guo X.:
 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, United States

Ciullo M.:
 Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR, Naples, Italy

 IRCCS Neuromed, Isernia, Pozzilli, Italy

Jonas J.B.:
 Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China

 Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, Mannheim, 68167, Germany

 Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland

 Privatpraxis Prof Jonas Und Dr Panda-Jonas, Heidelberg, Germany

Samani N.J.:
 Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

 NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Kaprio J.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

Pajukanta P.:
 Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, United States

Tusié-Luna T.:
 Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico

Aguilar-Salinas C.A.:
 Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico, 14080, Mexico

Adair L.S.:
 Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, United States

 Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, United States

Bechayda S.A.:
 USC–Office of Population Studies Foundation, University of San Carlos, Cebu City, 6000, Philippines

 Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, 6000, Philippines

de Silva H.J.:
 Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka

Wickremasinghe A.R.:
 Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka

Krauss R.M.:
 Children’s Hospital Oakland Research Institute, Oakland, CA 94609, United States

Wu J.-Y.:
 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Zheng W.:
 Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, United States

Hollander A.I.:
 Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, Netherlands

Bharadwaj D.:
 Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Uttar Pradesh, Ghaziabad, India

 Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India

Correa A.:
 Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States

Wilson J.G.:
 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, United States

Lind L.:
 Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Heng C.-K.:
 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children’s Medical Institute, National University Health System, Singapore, Singapore

Nelson A.E.:
 Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States

 Department of Medicine, University of North Carolina, Chapel Hill, NC, United States

Golightly Y.M.:
 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States

 Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, United States

 Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, United States

 Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, United States

Wilson J.F.:
 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom

 Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, United Kingdom

Penninx B.:
 Amsterdam Public Health Research Institute, Amsterdam UMC, Netherlands

 Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Kim H.-L.:
 Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, South Korea

Attia J.:
 Hunter Medical Research Institute, Newcastle, Australia

 Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia

Scott R.J.:
 Hunter Medical Research Institute, Newcastle, Australia

 Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia

Rao D.C.:
 Division of Biostatistics, Washington University School of Medicine, St. Louis, United States

Arnett D.K.:
 Office of the Provost, University of South Carolina, Columbia, SC, United States

Hunt S.C.:
 Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

 Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, United States

Walker M.:
 Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, United Kingdom

Koistinen H.A.:
 Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland

 Department of Medicine, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, P.O.Box 340, Helsinki, 00029, Finland

 Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, 00290, Finland

Chandak G.R.:
 Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

 JSS Academy of Higher Education and Research, Mysuru, India

Mercader J.M.:
 Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States

 Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States

 Harvard Medical School, Boston, MA 02115, United States

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Costanzo M.C.:
 Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Jang D.:
 Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Burtt N.P.:
 Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Villalpando C.G.:
 InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico

Orozco L.:
 Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico

Fornage M.:
 Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, United States

 Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Tai E.S.:
 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore

 Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 119228, Singapore

van Dam R.M.:
 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore

 Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC 20052, United States

Lehtimäki T.:
 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland

 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland

Chaturvedi N.:
 MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, United Kingdom

Yokota M.:
 Kurume University School of Medicine, Kurume, 830-0011, Japan

Liu J.:
 Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Reilly D.F.:
 Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ 07033, United States

McKnight A.J.:
 Centre for Public Health, Queen’s University of Belfast, Belfast, United Kingdom

Kee F.:
 Centre for Public Health, Queen’s University of Belfast, Belfast, United Kingdom

Jöckel K.-H.:
 Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

McCarthy M.I.:
 Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom

 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

Palmer C.N.A.:
 Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, United Kingdom

Vitart V.:
 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom

Hayward C.:
 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom

Simonsick E.:
 Intramural Research Program, National Institute On Aging, 3001 S. Hanover St., Baltimore, MD 21225, United States

van Duijn C.M.:
 Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Jin Z.-B.:
 Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, 100730, China

 The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, Wenzhou, 325027, China

Qu J.:
 The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, Wenzhou, 325027, China

Hishigaki H.:
 Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

Lin X.:
 Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

März W.:
 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany

 Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany

 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

Gudnason V.:
 Icelandic Heart Association, Kopavogur, 201, Iceland

 Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland

Tardif J.-C.:
 Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ H1T1C8, Canada

Lettre G.:
 Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ H1T1C8, Canada

Hart L.M.:
 Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands

 Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands

 Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, 1081HV, Netherlands

 Amsterdam Public Health Research Institute, Amsterdam Cardiovascular Sciences, Amsterdam, 1081HV, Netherlands

Elders P.J.M.:
 Department of General Practice, Amsterdam UMC, Amsterdam, 1081HV, Netherlands

 Amsterdam Public Health Research Institute, Health Behaviours and Chronic Diseases, Amsterdam, 1081HV, Netherlands

Damrauer S.M.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

 Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States

 Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, United States

Kumari M.:
 Institute of Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, United Kingdom

Kivimaki M.:
 Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, United Kingdom

van der Harst P.:
 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

 Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Spector T.D.:
 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom

Loos R.J.F.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

 The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States

 Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Province M.A.:
 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States

Parra E.J.:
 Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada

Cruz M.:
 Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico

Psaty B.M.:
 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, United States

 Department of Epidemiology, University of Washington, Seattle, WA, United States

 Department of Health Systems and Population Health, University of Washington, Seattle, WA, United States

Brandslund I.:
 Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark

 Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

Pramstaller P.P.:
 Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, Bolzano, 39100, Italy

Rotimi C.N.:
 Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD 20892, United States

Christensen K.:
 Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark

Ripatti S.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

 Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland

 Broad Institute of MIT and Harvard, Cambridge, MA, United States

Widén E.:
 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, Helsinki, 00014, Finland

Hakonarson H.:
 Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, United States

 Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States

Grant S.F.A.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

 Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States

 Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, United States

Kiemeney L.A.L.M.:
 Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands

de Graaf J.:
 Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands

Loeffler M.:
 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, Leipzig, 04107, Germany

 LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, Leipzig, 04103, Germany

Kronenberg F.:
 Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria

 German Chronic Kidney Disease Study, Berlin, Germany

Gu D.:
 Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

 School of Medicine, Southern University of Science and Technology, Shenzhen, China

Erdmann J.:
 Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany

Schunkert H.:
 Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany

 Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany

Franks P.W.:
 Lund University Diabetes Center, Lund University, Malmö, Sweden

Linneberg A.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Jukema J.W.:
 Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands

 Netherlands Heart Institute, Utrecht, Netherlands

Khera A.V.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States

 Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States

 Department of Medicine, Harvard Medical School, Boston, MA, United States

 Verve Therapeutics, Cambridge, MA, United States

Männikkö M.:
 Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland

Jarvelin M.-R.:
 Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom

 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland

 Biocenter of Oulu, University of Oulu, Oulu, Finland

Kutalik Z.:
 University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, Lausanne, 1010, Switzerland

 Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland

Francesco C.:
 Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy

 University of Sassari, Sassari, Italy

Mook-Kanamori D.O.:
 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

 Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands

van Dijk K.W.:
 Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands

 Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands

 Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Watkins H.:
 Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom

 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom

Strachan D.P.:
 Population Health Research Institute, St George’s, University of London, London, SW17 0RE, United Kingdom

Grarup N.:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Sever P.:
 National Heart and Lung Institute, Imperial College London, London, W12 0NN, United Kingdom

Poulter N.:
 School of Public Health, Imperial College London, London, W12 7RH, United Kingdom

Chuang L.-M.:
 Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan

Rotter J.I.:
 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, United States

Dantoft T.M.:
 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

Karpe F.:
 OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, United Kingdom

 NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

Neville M.J.:
 OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, United Kingdom

 NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

Timpson N.J.:
 MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

 Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, United Kingdom

Cheng C.-Y.:
 Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore

 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore

Wong T.-Y.:
 Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore

 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore

Khor C.C.:
 Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

Li H.:
 Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Sabanayagam C.:
 Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore

 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore

Peters A.:
 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

 Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany

 German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

Gieger C.:
 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

 German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

Hattersley A.T.:
 Medical School, University of Exeter, University of Exeter, Exeter, EX2 5DW, United Kingdom

Pedersen N.L.:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Magnusson P.K.E.:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Boomsma D.I.:
 Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

 Amsterdam Public Health Research Institute, Amsterdam UMC, Netherlands

Willemsen A.H.M.:
 Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

 Amsterdam Public Health Research Institute, Amsterdam UMC, Netherlands

Cupples L.A.:
 Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA 02118, United States

 Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, United States

van Meurs J.B.J.:
 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Ghanbari M.:
 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

 Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Gordon-Larsen P.:
 Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, United States

 Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, United States

Huang W.:
 Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China

Kim Y.J.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Tabara Y.:
 Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Wareham N.J.:
 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, United Kingdom

Langenberg C.:
 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, United Kingdom

 Computational Medicine, Berlin Institute of Health at Charité – Universitätsmedizin, Berlin, Germany

Zeggini E.:
 Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

 Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

 Technical University of Munich (TUM) and Klinikum Rechts Der Isar, TUM School of Medicine, Munich, Germany

Kuusisto J.:
 Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Laakso M.:
 Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Ingelsson E.:
 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States

 Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

 Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, United States

 Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, United States

Abecasis G.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

 Regeneron Pharmaceuticals, Tarrytown, NY, United States

Chambers J.C.:
 Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, United Kingdom

 Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, United Kingdom

 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore

 Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, United Kingdom

Kooner J.S.:
 Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, United Kingdom

 School of Public Health, Imperial College London, London, W12 7RH, United Kingdom

 Imperial College Healthcare NHS Trust, London, W12 0HS, United Kingdom

 MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, United Kingdom

de Vries P.S.:
 Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Morrison A.C.:
 Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States

Hazelhurst S.:
 Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

 School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa

Ramsay M.:
 Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

North K.E.:
 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States

Daviglus M.:
 Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, United States

Kraft P.:
 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States

 Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States

Martin N.G.:
 QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia

Whitfield J.B.:
 QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia

Abbas S.:
 Center for Non-Communicable Diseases, Sindh, Karachi, Pakistan

 Faisalabad Institute of Cardiology, Faislabad, Pakistan

Saleheen D.:
 Center for Non-Communicable Diseases, Sindh, Karachi, Pakistan

 Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States

 Department of Cardiology, Columbia University Irving Medical Center, New York, NY, United States

Walters R.G.:
 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 Big Data Institute, University of Oxford, Oxford, OX3 7LF, United Kingdom

Holmes M.V.:
 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom

 National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, United Kingdom

Black C.:
 Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom

Smith B.H.:
 Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom

Baras A.:
 Regeneron Pharmaceuticals, Tarrytown, NY, United States

Justice A.E.:
 Department of Population Health Sciences, Geisinger Health, Danville, PA 17822, United States

Buring J.E.:
 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, United States

 Harvard Medical School, Boston, MA 02115, United States

Ridker P.M.:
 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, United States

 Harvard Medical School, Boston, MA 02115, United States

Chasman D.I.:
 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, United States

 Harvard Medical School, Boston, MA 02115, United States

Kooperberg C.:
 Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA 9810, United States

Tamiya G.:
 Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan

Yamamoto M.:
 Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan

van Heel D.A.:
 Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Trembath R.C.:
 School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

Wei W.-Q.:
 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States

Jarvik G.P.:
 Departments of Medicine (Medical Genetics) and Genome Sciences, University of WashingtonWA, United States

Namjou B.:
 Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center (CCHMC), Cincinnati, OH, United States

Hayes M.G.:
 Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60618, United States

 Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60618, United States

 Department of Anthropology, Northwestern University, Evanston, IL 60208, United States

Ritchie M.D.:
 Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, United States

Jousilahti P.:
 Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland

Salomaa V.:
 Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland

Hveem K.:
 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

 Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway

 Department of Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Åsvold B.O.:
 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

 Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway

 Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Kubo M.:
 RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

Kamatani Y.:
 RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

 Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

Okada Y.:
 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan

 RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

 Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

 Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

Murakami Y.:
 Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Kim B.-J.:
 Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea

Thorsteinsdottir U.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

 Faculty of Medicine, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland

Stefansson K.:
 deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland

 Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, United Kingdom

Zhang J.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

Chen Y.E.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

Ho Y.-L.:
 VA Boston Healthcare System, Boston, MA, United States

Lynch J.A.:
 VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, United States

 University of Massachusetts, Boston, MA, United States

Rader D.J.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

Tsao P.S.:
 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States

 Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States

Chang K.-M.:
 Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States

 Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Cho K.:
 VA Boston Healthcare System, Boston, MA, United States

 Department of Medicine, Brigham Women’s Hospital, Boston, MA, United States

O’Donnell C.J.:
 VA Boston Healthcare System, Boston, MA, United States

 Department of Medicine, Brigham Women’s Hospital, Boston, MA, United States

Gaziano J.M.:
 VA Boston Healthcare System, Boston, MA, United States

 Department of Medicine, Brigham Women’s Hospital, Boston, MA, United States

Wilson P.W.F.:
 Atlanta VA Health Care System, Decatur, GA, United States

 Division of Cardiology, Emory University School of Medicine, Atlanta, GA, United States

Frayling T.M.:
 Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, United Kingdom

Hirschhorn J.N.:
 Boston Children’s Hospital, EndocrinologyBoston, MA 02115, United States

 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, United States

Kathiresan S.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States

 Department of Medicine, Harvard Medical School, Boston, MA, United States

Mohlke K.L.:
 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States

Sun Y.V.:
 Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States

 Atlanta VA Health Care System, Decatur, GA, United States

Morris A.P.:
 Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, United Kingdom

Boehnke M.:
 Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States

Brown C.D.:
 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

Natarajan P.:
 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States

 Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

 Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States

Deloukas P.:
 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

 Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia

Willer C.J.:
 Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, United States

 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States

 Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, United States

Assimes T.L.:
 VA Palo Alto Health Care Systems, Palo Alto, CA, United States

 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States

 Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States

Peloso G.M.:
 Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA 02118, United States
ISSN: 14747596





GENOME BIOLOGY
Editorial
BioMed Central Ltd, GB
Tipo de documento: Article
Volumen: 23 Número: 1
Páginas:
WOS Id: 000927879600003
ID de PubMed: 36575460
imagen All Open Access, Gold

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