Effects of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on Lipoprotein Atherogenicity
Por:
Farras, M, Canyelles, M, Fito, M, Escola-Gil, JC
Publicada:
1 mar 2020
Resumen:
The atherogenicity of low-density lipoprotein (LDL) and triglyceride-rich lipoproteins (TRLs) may be more significant than LDL cholesterol levels. Clinical trials which have led to increased high-density lipoprotein (HDL) cholesterol have not always seen reductions in cardiovascular disease (CVD). Furthermore, genetic variants predisposing individuals to high HDL cholesterol are not associated with a lower risk of suffering a coronary event, and therefore HDL functionality is considered to be the most relevant aspect. Virgin olive oil (VOO) is thought to play a protective role against CVD. This review describes the effects of VOO and phenol-enriched VOOs on lipoprotein atherogenicity and HDL atheroprotective properties. The studies have demonstrated a decrease in LDL atherogenicity and an increase in the HDL-mediated macrophage cholesterol efflux capacity, HDL antioxidant activity, and HDL anti-inflammatory characteristics after various VOO interventions. Moreover, the expression of cholesterol efflux-related genes was enhanced after exposure to phenol-enriched VOOs in both post-prandial and sustained trials. Improvements in HDL antioxidant properties were also observed after VOO and phenol-enriched VOO interventions. Furthermore, some studies have demonstrated improved characteristics of TRL atherogenicity under postprandial conditions after VOO intake. Large-scale, long-term randomized clinical trials, and Mendelian analyses which assess the lipoprotein state and properties, are required to confirm these results.
Filiaciones:
Farras, M:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Mol Bases Cardiovasc Risk Grp, Barcelona 08041, Spain
ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain
Canyelles, M:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Mol Bases Cardiovasc Risk Grp, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Bioquim Biol Mol & Biomed, Barcelona 08193, Spain
Fito, M:
Hosp del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona 08003, Spain
ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain
Escola-Gil, JC:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Mol Bases Cardiovasc Risk Grp, Barcelona 08041, Spain
ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Bioquim Biol Mol & Biomed, Barcelona 08193, Spain
Gold, Green Published
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