Effectiveness and safety of tocilizumab in patients with systemic sclerosis: a propensity score matched controlled observational study of the EUSTAR cohort

Por: Kuster S., Jordan S., Elhai M., Held U., Steigmiller K., Bruni C., Cacciapaglia F., Vettori S., Siegert E., Rednic S., Codullo V., Airo P., Braun-Moscovici Y., Hunzelmann N., Joao Salvador M., Riccieri V., Gheorghiu A.-M., Alegre Sancho J.J., Romanowska-Prochnicka K., Castellví I., Kötter I., Truchetet M.-E., López-Longo F.J., Novikov P.I., Giollo A., Shirai Y., Belloli L., Zanatta E., Hachulla E., Smith V., Denton C., Ionescu R.M., Schmeiser T., Distler J.H.W., Gabrielli A., Hoffmann-Vold A.-M., Kuwana M., Allanore Y., Distler O.

---

Publicada: 1 ene 2022

---

---

Filiaciones:
Kuster S.:
 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Jordan S.:
 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Elhai M.:
 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

 Department of Rheumatology, Paris Descartes University, Cochin Hospital, Aphp, Paris, France

Held U.:
 Department of Biostatistics at Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

Steigmiller K.:
 Department of Biostatistics at Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

Bruni C.:
 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

 Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy

Cacciapaglia F.:
 Rheumatology Unit, Deto, University Hospital Polyclinic of Bari, Bari, Italy

Vettori S.:
 Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy

Siegert E.:
 Clinic for Rheumatology and Immunology, Bad Bramstedt, Germany

 Berlin Institute of Health at Charité, Berlin, Germany

Rednic S.:
 Clinica Reumatologie, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Codullo V.:
 Department of Rheumatology, Irccs Foundation Policlinico San Matteo, Pavia, Italy

Airo P.:
 Uoc Rheumatology and Clinical Immunology, Spedali Civili di Brescia, Brescia, Italy

Braun-Moscovici Y.:
 B. Shine Department of Rheumatology, Rambam Health Care Campus and Technion, Haifa, Israel

Hunzelmann N.:
 University of Cologne, Cologne, Germany

Joao Salvador M.:
 Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

Riccieri V.:
 Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy

Gheorghiu A.-M.:
 Department of Internal Medicine and Rheumatology, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Alegre Sancho J.J.:
 Department of Rheumatology, Hospital Peset, Valencia, Spain

Romanowska-Prochnicka K.:
 Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland

 Department of Connective Tissues Diseases, Institute of Rheumatology, Warsaw, Poland

Castellví I.:
 Department of Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Kötter I.:
 Clinic for Rheumatology and Immunology, Bad Bramstedt, Germany

 University Hospital Hamburg-Eppendorf, Division of Rheumatology and Systemic Inflammatory Diseases, Hamburg, Germany

Truchetet M.-E.:
 Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

López-Longo F.J.:
 Department of Rheumatology, National Reference Center for Systemic Autoimmune Rare Diseases, Hopital Pellegrin, Bordeaux, France

Novikov P.I.:
 Department of Rheumatology, National Reference Center for Systemic Autoimmune Rare Diseases, Hopital Pellegrin, Bordeaux, France

Giollo A.:
 Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy

Shirai Y.:
 Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

Belloli L.:
 Rheumatology Unit, Asst Grande Ospedale Metropolitano Niguarda, Milano, Italy

Zanatta E.:
 Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy

Hachulla E.:
 Referral Centre for Rare Systemic Auto-immune Diseases for North and North-West of France, Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille, France

Smith V.:
 Department of Internal Medicine, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium

 Unit for Molecular Immunology and Inflammation, Vib Inflammation Research Centre (IRC), Ghent, Belgium

Denton C.:
 Centre for Rheumatology, University College London Medical School, Royal Free Campus, London, United Kingdom

Ionescu R.M.:
 Internal Medicine and Rheumatology Department, St. Maria Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Schmeiser T.:
 Krankenhaus St. Josef, Elberfeld, Wuppertal, Germany

Distler J.H.W.:
 Department of Internal Medicine Iii, Erlangen University Hospital, Erlangen, Germany

Gabrielli A.:
 Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica Delle Marche, Ancona, Italy

Hoffmann-Vold A.-M.:
 Department of Rheumatology, Rikshospitalet University Hospital Oslo, Oslo, Norway

Kuwana M.:
 Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

Allanore Y.:
 Department of Rheumatology, Paris Descartes University, Cochin Hospital, Aphp, Paris, France

Distler O.:
 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland