Efficacy of ixekizumab in patients with moderate-to-severe plaque psoriasis and prediabetes or type 2 diabetes
Por:
Egeberg A., Merola J.F., Schäkel K., Puig L., Mahar P.D., Wang I.Y., Pavo I., Schuster C., Griffiths C.E.M.
Publicada:
1 ene 2023
Ahead of Print:
27 ene 2023
Resumen:
Objective: Patients with psoriasis have an increased prevalence of type 2 diabetes when compared to the general population. Research suggests that type 2 diabetes (T2D) as well as obesity may have an impact on patients' response to treatment. This post-hoc analysis reports the efficacy of ixekizumab in treating moderate-to-severe psoriasis in patients with prediabetes or T2D. Method and materials: UNCOVER-1, UNCOVER-2, and UNCOVER-3 were three Phase 3, multicenter, randomized, double-blind, placebo-controlled trials that evaluated the efficacy and safety of ixekizumab in adult patients with moderate-to-severe psoriasis. Patients were aged =18 years with chronic moderate-to-severe psoriasis (defined as =10% body surface area affected, static Physician Global Assessment =3, and Psoriasis Area and Severity Index [PASI] =12 at screening and baseline) who were candidates for phototherapy or systemic therapy. UNCOVER-1, UNCOVER-2, and UNCOVER-3 participants received ixekizumab as per label (that is, an initial dose of two subcutaneous injections [160 mg in total] at Week 0, followed by 80 mg every 2 weeks through Week 12 and 80 mg every 4 weeks thereafter through Week 60). Results: The proportions of patients with prediabetes, T2D and normoglycemia that achieved PASI75, PASI90, and PASI100 at Week 60 were similar. Results suggest that patients with T2D were slower to achieve PASI100 than patients with prediabetes or those with normoglycemia. Ixekizumab had no effect on any metabolic markers in patients receiving the treatment. Conclusions: Despite the higher rate of obesity and extreme obesity in patients with prediabetes and T2D, ixekizumab was an efficacious treatment in treating patients with psoriasis. Copyright © 2023 Egeberg, Merola, Schäkel, Puig, Mahar, Wang, Pavo, Schuster and Griffiths.
Filiaciones:
Egeberg A.:
Bispebjerg and Frederiksberg Hospital, Copenhagen University, Copenhagen, Denmark
Merola J.F.:
Division of Rheumatology, Department of Dermatology and Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States
Schäkel K.:
Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
Puig L.:
Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Mahar P.D.:
Eli Lilly and Company, Indianapolis, IN, United States
Department of Dermatology, Royal Children's Hospital, Faculty of Medicine, Nursing and Health Sciences, Skin Health Institute, The University of Melbourne, Melbourne, VIC, Australia
Wang I.Y.:
Eli Lilly and Company, Indianapolis, IN, United States
Pavo I.:
Eli Lilly and Company, Indianapolis, IN, United States
Schuster C.:
Eli Lilly and Company, Indianapolis, IN, United States
Department of Dermatology, Medical University of Vienna, Vienna, Austria
Griffiths C.E.M.:
Dermatology Centre, Salford Royal Hospital, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom
gold, Green Published, All Open Access, Gold, Green
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