Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects: A population-based study
Por:
Julián M.T., Ballesta S., Pera G., Pérez-Montes de Oca A., Soldevila B., Caballería L., Morillas R., Expósito C., Martínez–Escudé A., Puig-Domingo M., Franch-Nadal J., Torán P., Cusi K., Julve J., Mauricio D., Alonso N.
Publicada:
1 ene 2023
Ahead of Print:
13 ene 2023
Resumen:
Objective: To investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia. Material and Methods: A longitudinal adult population-based cohort study was conducted in Catalonia. LSM was measured by transient elastography (TE) at baseline and follow-up (median: 4.2 years). Subgroup with NAFLD and dysglycemia were analyzed. Moderate-to-advanced liver fibrosis was defined as LSM =8.0 kPa and LSM =9.2 kPa respectively. Results: Among 1.478 subjects evaluated, the cumulative incidence of LSM =8.0 kPa and =9.2 kPa at follow-up was 2.8% and 1.9%, respectively. This incidence was higher in NAFLD (7.1% for LSM =8.0 kPa and 5% for LSM =9.2 kPa) and dysglycemia (6.2% for LSM =8.0 kPa and 4.7% for LSM =9.2 kPa) subgroups. In the global cohort, the multivariate analyses showed that dysglycemia, abdominal obesity and atherogenic dyslipidemia were significantly associated with progression to moderate-to-advanced liver fibrosis. Female sex was negatively associated. In subjects with NAFLD, abdominal obesity and dysglycemia were associated with changes in LSM to =8.0 kPa and =9.2 kPa at follow-up. A decline in LSM value to <8 kPa was observed in 64% of those subjects with a baseline LSM =8.0 kPa. Conclusions: In this population study, the presence of abdominal obesity and dysglycemia were the main risk metabolic factors associated with moderate-to-advanced liver fibrosis development over time in general populations as well as in subjects with NAFLD. Copyright © 2023 Julián, Ballesta, Pera, Pérez-Montes de Oca, Soldevila, Caballería, Morillas, Expósito, Martínez–Escudé, Puig-Domingo, Franch-Nadal, Torán, Cusi, Julve, Mauricio and Alonso.
Filiaciones:
Julián M.T.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Ballesta S.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Pera G.:
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), Mataró, Spain
Pérez-Montes de Oca A.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Soldevila B.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Caballería L.:
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), Mataró, Spain
Centro d’Investigaciones Biomédicas en Red, Enfermedades Hepatologia y Digestivas, Barcelona, Spain
Morillas R.:
Centro d’Investigaciones Biomédicas en Red, Enfermedades Hepatologia y Digestivas, Barcelona, Spain
Hepatology Department, Hospital Germans Trias I Pujol, Badalona, Barcelona, Spain
Expósito C.:
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), Mataró, Spain
Centro d’Investigaciones Biomédicas en Red, Enfermedades Hepatologia y Digestivas, Barcelona, Spain
Martínez–Escudé A.:
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), Mataró, Spain
Primary Care, Centre d’Atenció Primària La Llagosta, Institut Català de la Salut, Barcelona, Spain
Puig-Domingo M.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases, CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Franch-Nadal J.:
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases, CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Primary Health Care Center Raval Sud, Gerència d’Atenció Primaria, Institut Català de la Salut, Barcelona, Spain
Torán P.:
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), Mataró, Spain
Centro d’Investigaciones Biomédicas en Red, Enfermedades Hepatologia y Digestivas, Barcelona, Spain
Cusi K.:
Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, United States
Julve J.:
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases, CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
Mauricio D.:
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases, CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
Faculty of Medicine, University of Vic, Central University of Catalonia, Vic, Spain
Alonso N.:
Department of Endocrinology and Nutrition, Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases, CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Green Published, gold, All Open Access, Gold, Green
|