Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period


Por: Gasso, P, Arnaiz, JA, Mas, S, Lafuente, A, Bioque, M, Cuesta, MJ, Diaz-Caneja, CM, Garcia, C, Lobo, A, Gonzalez-Pinto, A, Parellada, M, Corripio, I, Vieta, E, Castro-Fornieles, J, Mane, A, Rodriguez, N, Bolac, D, Saiz-Ruiz, J, Bernardo, M, Mezquida, G, Amoretti, S, Pina-Camacho, L, Gonzalez-Penas, J, Alonso-Solis, A, Rabetla, M, Zorrilla, I, Garcia, S, Barcones, F, Modrego, P, Sanjuan, J, Nacher, J, Berge, D, Monserrat, C, Verdolini, N, Gil-Badenes, J, Baeza, I, de la Serna, E, Contreras, F, Saiz-Masvidal, C, Garcia-Portilla, MP, Bobes, J, Gutierrez, M, Segarra, R, Dompablo, M, Rodriguez-Jimenez, R, Usall, J, Butjosa, A, Sarro, S, Pomarol-Clotet, E, Ibanez, A, Ribeiro, M, Selva-Vera, G

Publicada: 1 may 2020 Ahead of Print: 1 feb 2020
Resumen:
Aims: Patients with a first episode of psychosis (FEP) often display different metabolic disturbances even independently of drug therapy. However, antipsychotic (AP) treatment, especially with second-generation APs, is strongly linked to weight gain, which increases patients' risk of developing obesity and other metabolic diseases. There is an important genetic risk component that can contribute to the appearance of these disturbances. The aim of the present study was to evaluate the effect of polymorphisms in selected candidate genes on obesity and other anthropometric and metabolic traits in 320 AP-treated FEP patients over the course of a 2-year follow-up. Methods: These patients were recruited in the multicentre PEPs study (Phenotype-genotype and environmental interaction; Application of a predictive model in first psychotic episodes). A total of 127 validated single nucleotide polymorphisms (SNPs) in 18 candidate genes were included in the genetic analysis. Results: After Bonferroni correction, SNPs in ADRA2A, FTO, CNR1, DRD2, DRD3, LEPR and BDNF were associated with obesity, abdominal circumference, triglycerides, HDL cholesterol, and/or percentage of glycated haemoglobin. Conclusions: Although our results should be interpreted as exploratory, they support previous evidence of the impact of these candidate genes on obesity and metabolic status. Further research is required to gain a better knowledge of the genetic variants that can be considered relevant metabolic risk factors. The ability to identify FEP patients at higher risk for these metabolic disturbances would enable clinicians to better select and control their AP treatment.

Filiaciones:
Gasso, P:
 Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain

 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

Arnaiz, JA:
 Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain

Mas, S:
 Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain

 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

Lafuente, A:
 Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain

 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

Bioque, M:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain

 Univ Barcelona, Dept Med, Barcelona, Spain

Cuesta, MJ:
 Complejo Hosp Navarra, Inst Invest Sanitarias Navarra IdiSNa, Dept Psychiat, Pamplona, Spain

Diaz-Caneja, CM:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain

Garcia, C:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain

 Univ Barcelona, Dept Med, Barcelona, Spain

Lobo, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain

Gonzalez-Pinto, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain

Parellada, M:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain

Corripio, I:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain

 Univ Autonoma Barcelona, Barcelona, Spain

Vieta, E:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Barcelona, Dept Med, Barcelona, Spain

 Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain

Castro-Fornieles, J:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Barcelona, Dept Med, Barcelona, Spain

 Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain

Mane, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain

Rodriguez, N:
 FCRB, Barcelona, Spain

Bolac, D:
 Univ Barcelona, Dept Med, Barcelona, Spain

Saiz-Ruiz, J:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Alcala De Henares, Hosp Univ Ramon y Cajal, Dept Psychiat, IRYCIS, Madrid, Spain

Bernardo, M:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain

 Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain

Mezquida, G:
 Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain

 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain

Amoretti, S:
 Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain

Pina-Camacho, L:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain

Gonzalez-Penas, J:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain

Alonso-Solis, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain

 Univ Autonoma Barcelona, Barcelona, Spain

Rabetla, M:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain

 Univ Autonoma Barcelona, Barcelona, Spain

Zorrilla, I:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain

Garcia, S:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain

Barcones, F:
 Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain

 Hosp Univ Miguel Servet, Zaragoza, Spain

Modrego, P:
 Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain

 Hosp Univ Miguel Servet, Zaragoza, Spain

Sanjuan, J:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain

Nacher, J:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain

Berge, D:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain

Monserrat, C:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain

Verdolini, N:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

Gil-Badenes, J:
 Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain

 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain

Baeza, I:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain

de la Serna, E:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain

Contreras, F:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Barcelona, Bellvitge Univ Hosp IDIBELL, Sch Med, Dept Psychiat,Dept Clin Sci, Barcelona, Spain

Saiz-Masvidal, C:
 Univ Barcelona, Bellvitge Univ Hosp IDIBELL, Sch Med, Dept Psychiat,Dept Clin Sci, Barcelona, Spain

Garcia-Portilla, MP:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Oviedo, Dept Psychiat, Oviedo, Spain

Bobes, J:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Oviedo, Dept Psychiat, Oviedo, Spain

Gutierrez, M:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain

Segarra, R:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Basque Country, Cruces Univ Hosp, BioCruces Hlth Res Inst, UPV EHU, Vizcaya, Spain

Dompablo, M:
 Inst Invest Hosp 12 Octubre Imas 12, Madrid, Spain

 Univ Complutense Madrid, Madrid, Spain

Rodriguez-Jimenez, R:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Inst Invest Hosp 12 Octubre Imas 12, Madrid, Spain

 Univ Complutense Madrid, Madrid, Spain

Usall, J:
 Inst Recerca St Joan, Parc Sanitari St Joan Deu, Barcelona, Spain

Butjosa, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Inst Recerca St Joan, Parc Sanitari St Joan Deu, Barcelona, Spain

Sarro, S:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain

Pomarol-Clotet, E:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain

Ibanez, A:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

Ribeiro, M:
 Complejo Hosp Navarra, Inst Invest Sanitarias Navarra IdiSNa, Dept Psychiat, Pamplona, Spain

Selva-Vera, G:
 Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

 Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain
ISSN: 02698811





JOURNAL OF PSYCHOPHARMACOLOGY
Editorial
SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 34 Número: 5
Páginas: 514-523
WOS Id: 000511544900001
ID de PubMed: 32009515

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