Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period
Por:
Gasso, P, Arnaiz, JA, Mas, S, Lafuente, A, Bioque, M, Cuesta, MJ, Diaz-Caneja, CM, Garcia, C, Lobo, A, Gonzalez-Pinto, A, Parellada, M, Corripio, I, Vieta, E, Castro-Fornieles, J, Mane, A, Rodriguez, N, Bolac, D, Saiz-Ruiz, J, Bernardo, M, Mezquida, G, Amoretti, S, Pina-Camacho, L, Gonzalez-Penas, J, Alonso-Solis, A, Rabetla, M, Zorrilla, I, Garcia, S, Barcones, F, Modrego, P, Sanjuan, J, Nacher, J, Berge, D, Monserrat, C, Verdolini, N, Gil-Badenes, J, Baeza, I, de la Serna, E, Contreras, F, Saiz-Masvidal, C, Garcia-Portilla, MP, Bobes, J, Gutierrez, M, Segarra, R, Dompablo, M, Rodriguez-Jimenez, R, Usall, J, Butjosa, A, Sarro, S, Pomarol-Clotet, E, Ibanez, A, Ribeiro, M, Selva-Vera, G
Publicada:
1 may 2020
Ahead of Print:
1 feb 2020
Resumen:
Aims:
Patients with a first episode of psychosis (FEP) often display different metabolic disturbances even independently of drug therapy. However, antipsychotic (AP) treatment, especially with second-generation APs, is strongly linked to weight gain, which increases patients' risk of developing obesity and other metabolic diseases. There is an important genetic risk component that can contribute to the appearance of these disturbances. The aim of the present study was to evaluate the effect of polymorphisms in selected candidate genes on obesity and other anthropometric and metabolic traits in 320 AP-treated FEP patients over the course of a 2-year follow-up.
Methods:
These patients were recruited in the multicentre PEPs study (Phenotype-genotype and environmental interaction; Application of a predictive model in first psychotic episodes). A total of 127 validated single nucleotide polymorphisms (SNPs) in 18 candidate genes were included in the genetic analysis.
Results:
After Bonferroni correction, SNPs in ADRA2A, FTO, CNR1, DRD2, DRD3, LEPR and BDNF were associated with obesity, abdominal circumference, triglycerides, HDL cholesterol, and/or percentage of glycated haemoglobin.
Conclusions:
Although our results should be interpreted as exploratory, they support previous evidence of the impact of these candidate genes on obesity and metabolic status. Further research is required to gain a better knowledge of the genetic variants that can be considered relevant metabolic risk factors. The ability to identify FEP patients at higher risk for these metabolic disturbances would enable clinicians to better select and control their AP treatment.
Filiaciones:
Gasso, P:
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Arnaiz, JA:
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Mas, S:
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Lafuente, A:
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Bioque, M:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Inst Invest Sanitarias Navarra IdiSNa, Dept Psychiat, Pamplona, Spain
Diaz-Caneja, CM:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain
Garcia, C:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Lobo, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain
Parellada, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain
Corripio, I:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Vieta, E:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain
Castro-Fornieles, J:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Mane, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain
Rodriguez, N:
FCRB, Barcelona, Spain
Bolac, D:
Univ Barcelona, Dept Med, Barcelona, Spain
Saiz-Ruiz, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Alcala De Henares, Hosp Univ Ramon y Cajal, Dept Psychiat, IRYCIS, Madrid, Spain
Bernardo, M:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain
Mezquida, G:
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Amoretti, S:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Pina-Camacho, L:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain
Gonzalez-Penas, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM, Madrid, Spain
Alonso-Solis, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Rabetla, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Zorrilla, I:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain
Garcia, S:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain
Barcones, F:
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Hosp Univ Miguel Servet, Zaragoza, Spain
Modrego, P:
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Hosp Univ Miguel Servet, Zaragoza, Spain
Sanjuan, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain
Nacher, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain
Berge, D:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain
Monserrat, C:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp del Mar, Med Res Inst IMIM, Barcelona, Spain
Verdolini, N:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Gil-Badenes, J:
Inst Invest Biom Diques August Pi & Sunyer IDIBAP, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorder Unit, Barcelona, Spain
Baeza, I:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
de la Serna, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Contreras, F:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Bellvitge Univ Hosp IDIBELL, Sch Med, Dept Psychiat,Dept Clin Sci, Barcelona, Spain
Saiz-Masvidal, C:
Univ Barcelona, Bellvitge Univ Hosp IDIBELL, Sch Med, Dept Psychiat,Dept Clin Sci, Barcelona, Spain
Garcia-Portilla, MP:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Oviedo, Dept Psychiat, Oviedo, Spain
Bobes, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Oviedo, Dept Psychiat, Oviedo, Spain
Gutierrez, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Serv Psiquiatria, Hosp Univ Araba, Bioaraba, Spain
Segarra, R:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Cruces Univ Hosp, BioCruces Hlth Res Inst, UPV EHU, Vizcaya, Spain
Dompablo, M:
Inst Invest Hosp 12 Octubre Imas 12, Madrid, Spain
Univ Complutense Madrid, Madrid, Spain
Rodriguez-Jimenez, R:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Hosp 12 Octubre Imas 12, Madrid, Spain
Univ Complutense Madrid, Madrid, Spain
Usall, J:
Inst Recerca St Joan, Parc Sanitari St Joan Deu, Barcelona, Spain
Butjosa, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Recerca St Joan, Parc Sanitari St Joan Deu, Barcelona, Spain
Sarro, S:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain
Pomarol-Clotet, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain
Ibanez, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Ribeiro, M:
Complejo Hosp Navarra, Inst Invest Sanitarias Navarra IdiSNa, Dept Psychiat, Pamplona, Spain
Selva-Vera, G:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Valencia, Hosp Clin Univ Valencia, INCLIVA, Valencia, Spain
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