Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study


Por: Martinez-Solano, J, Gutierrez-Ibanes, E, Ortiz-Bautista, C, Garcia-Cosio, MD, Sarnago-Cebada, F, Diaz-Molina, B, Pascual, I, Oteo-Dominguez, JF, Gomez-Bueno, M, Calvino-Santos, R, Crespo-Leiro, MG, Gomez-Hospital, JA, Diez-Lopez, C, Garcia-Lara, J, Garrido-Bravo, IP, de la Fuente-Galan, L, Lopez-Diaz, J, Mirabet-Perez, S, Martinez-Selles, M

Publicada: 1 dic 2022
Resumen:
Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3-50.0 vs. 47.0 mmHg, IQR 34.6-59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3-3.7 vs. 2.0 Wood units, IQR 1.4-3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 +/- 0.5 mm vs. 0.2 +/- 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.

Filiaciones:
Martinez-Solano, J:
 Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Serv Cardiol, Madrid 28007, Spain

 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

Gutierrez-Ibanes, E:
 Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Serv Cardiol, Madrid 28007, Spain

 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

Ortiz-Bautista, C:
 Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Serv Cardiol, Madrid 28007, Spain

 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

Garcia-Cosio, MD:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp 12 Octubre IMAS12, Serv Cardiol, Madrid 28041, Spain

Sarnago-Cebada, F:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp 12 Octubre IMAS12, Serv Cardiol, Madrid 28041, Spain

Diaz-Molina, B:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Cent Asturias, Serv Cardiol, Oviedo 33011, Spain

Pascual, I:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Cent Asturias, Serv Cardiol, Oviedo 33011, Spain

Oteo-Dominguez, JF:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Puerta Hierro Majadahonda, Serv Cardiol, Madrid 28222, Spain

Gomez-Bueno, M:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Puerta Hierro Majadahonda, Serv Cardiol, Madrid 28222, Spain

Calvino-Santos, R:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Complexo Hosp Univ ACoruna, Serv Cardioloxia, La Coruna 15006, Spain

Crespo-Leiro, MG:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Complexo Hosp Univ ACoruna, Serv Cardioloxia, La Coruna 15006, Spain

Gomez-Hospital, JA:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Bellvitge, Serv Cardiol, Barcelona 08907, Spain

Diez-Lopez, C:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Bellvitge, Serv Cardiol, Barcelona 08907, Spain

Garcia-Lara, J:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Clin Univ Virgen Arrixaca, Serv Cardiol, Murcia 30120, Spain

Garrido-Bravo, IP:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Clin Univ Virgen Arrixaca, Serv Cardiol, Murcia 30120, Spain

de la Fuente-Galan, L:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Clin Univ Valladolid, Serv Cardiol, Valladolid 47003, Spain

Lopez-Diaz, J:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Clin Univ Valladolid, Serv Cardiol, Valladolid 47003, Spain

Mirabet-Perez, S:
 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Hosp Univ Santa Creu & St Pau, Serv Cardiol, Barcelona 08025, Spain

Martinez-Selles, M:
 Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IISGM, Serv Cardiol, Madrid 28007, Spain

 Inst Salud Carlos III, Ctr Invest Red Enfermedades Cardiovasculares CIBE, Madrid 28026, Spain

 Univ Europea, Fac Ciencias Biomed & Salud, Madrid 28670, Spain
ISSN: 23083425
Editorial
MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 9 Número: 12
Páginas:
WOS Id: 000902691300001
ID de PubMed: 36547436
imagen Green Accepted, gold, Green Published, All Open Access, Gold, Green

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