Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients
Por:
Martin-Varillas, JL, Sanchez-Bilbao, L, Calvo-Rio, V, Adan, A, Hernanz, I, Gallego-Flores, A, Beltran-Catalan, E, Castro-Oreiro, S, Fanlo, P, Martos, AG, Torre, I, Cordero-Coma, M, De Dios, JR, Garcia-Aparicio, A, Hernandez-Garfella, M, Sanchez-Andrade, A, Garcia-Valle, A, Maiz, O, Miguelez, R, Rodriguez-Montero, S, Urruticoechea, A, Veroz, R, Conesa, A, Fernandez-Carballido, C, Jovani, V, Mondejar, JJ, Gonzalez, OM, Alvarado, PM, Romero-Yuste, S, Rubio-Munoz, P, Pena-Sainz-Pardo, E, Garijo-Bufort, M, Demetrio-Pablo, R, Hernandez, JL, Blanco, R
Publicada:
1 dic 2022
Resumen:
ObjectivesTo evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID).MethodsMulticentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year.ResultsWe studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6 +/- 11.7 years. The IMID included were: spondyloarthritis (n=43), Behcet's disease (n=10), psoriatic arthritis (n=8), Crohn's disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1),ConclusionsCZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.
Filiaciones:
Martin-Varillas, JL:
Hosp Comarcal Laredo, Rheumatol, Laredo, Spain
Sanchez-Bilbao, L:
Hosp Univ Marques Valdecilla, IDIVAL, Rheumatol, Santander, Spain
Calvo-Rio, V:
Hosp Univ Marques Valdecilla, IDIVAL, Rheumatol, Santander, Spain
Adan, A:
Hosp Clin Barcelona, Ophthalmol, Barcelona, Spain
Hernanz, I:
Hosp Clin Barcelona, Ophthalmol, Barcelona, Spain
Gallego-Flores, A:
Univ Hosp Complex Badajoz, Rheumatol, Badajoz, Spain
Beltran-Catalan, E:
Hosp del Mar, Rheumatol, Barcelona, Spain
Castro-Oreiro, S:
Joan XXIII Univ Hosp Tarragona, Rheumatol, Tarragona, Spain
Fanlo, P:
Complejo Hosp Navarra, Internal Med, Pamplona, Spain
Martos, AG:
Hosp Univ Tajo, Rheumatol, Aranjuez, Spain
Torre, I:
Hosp Basurto, Rheumatol, Basurto, Spain
Cordero-Coma, M:
Complejo Asistencial Univ Leon, Ophthalmol, Leon, Spain
De Dios, JR:
Araba Univ Hosp, Dept Rheumatol, Vitoria, Spain
Garcia-Aparicio, A:
Hosp Univ Toledo, Rheumatol, Toledo, Spain
Hernandez-Garfella, M:
Gen Univ Hosp Consortium Valencia, Ophthalmol, Valencia, Spain
Sanchez-Andrade, A:
Univ Hosp Lucus August, Rheumatol, Lugo, Spain
Garcia-Valle, A:
Complejo Asistencial Palencia, Rheumatol, Palencia, Spain
Maiz, O:
Hosp Donostia, Rheumatol, San Sebastian, Spain
Miguelez, R:
Hosp Univ Mostoles, Rheumatol, Mostoles, Spain
Rodriguez-Montero, S:
Hosp Virgen Valme, Rheumatol, Seville, Spain
Urruticoechea, A:
Hosp Can Misses, Rheumatol, Eivissa, Illes Balears, Spain
Veroz, R:
Hosp Merida, Rheumatol, Merida, Spain
Conesa, A:
Hosp Gen Univ Castello, Rheumatol, Castellon De La Plana, Spain
Fernandez-Carballido, C:
Hosp Univ San Juan Alicante, Rheumatol, Sant Joan dAlacant, Spain
Jovani, V:
Hosp Gen Univ Alicante, Rheumatol, Alicante, Spain
Mondejar, JJ:
Hosp Gen Univ Alicante, Ophthalmol, Alicante, Spain
Gonzalez, OM:
Hosp Univ Salamanca, Rheumatol, Salamanca, Spain
Alvarado, PM:
Hosp Santa Creu & Sant Pau, Rheumatol, Barcelona, Spain
Romero-Yuste, S:
Complejo Hosp Univ Pontevedra, Rheumatol, Pontevedra, Spain
Rubio-Munoz, P:
Fundacio Hosp Esperit St, Rheumatol, Barcelona, Spain
Pena-Sainz-Pardo, E:
Hosp Univ 12 Octubre, Pediat, Madrid, Spain
Garijo-Bufort, M:
Hosp Sagunto, Rheumatol, Sagunto, Spain
Demetrio-Pablo, R:
Hosp Univ Marques Valdecilla, IDIVAL, Ophthalmol, Santander, Spain
Hernandez, JL:
Hosp Univ Marques Valdecilla, IDIVAL, Internal Med, Santander, Spain
Univ Cantabria, Med & Psychiat Dept, Santander, Spain
Blanco, R:
Hosp Univ Marques Valdecilla, IDIVAL, Rheumatol, Santander, Spain
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