Epigenetic clocks in relapse after a first episode of schizophrenia
Por:
Segura À.-G., Prohens L., Mezquida G., Amoretti S., Bioque M., Ribeiro M., Gurriarán-Bas X., Rementería L., Berge D., Rodriguez-Jimenez R., Roldán A., Pomarol-Clotet E., Ibáñez A., Usall J., García-Portilla M.P., Cuesta M.J., Parellada M., González-Pinto A., Berrocoso E., Bernardo M., Mas S., González-Díaz J.M., Arbelo N., González-Peñas J., Pina-Camacho L., Diestre A., Selma J., Zorrilla I., López P., Trabsa A., Monserrat C., Sanchez-Pastor L., Nuñez-Doyle A., Fatjó-Vilas M., Sarró S., Butjosa A., Pardo M., López-Ilundain J.M., Sánchez Torres A.M., Saiz-Ruiz J., Ochoa-Mangado E., RIevero O., De-la-Cámara C., Echevarría R.S., González-Blanco L.
Publicada:
1 ene 2022
Resumen:
The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages. © 2022, The Author(s).
Filiaciones:
Segura À.-G.:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Prohens L.:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Mezquida G.:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Amoretti S.:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Bioque M.:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Ribeiro M.:
Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Gurriarán-Bas X.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Rementería L.:
Department of Psychiatry, Hospital Universitario de Alava, Vitoria, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Vitoria, Spain
BIOARABA Health Research Institute, Vitoria, Spain
Berge D.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Hospital del Mar Medicar Research Institute (IMIM), Barcelona, Spain
Autonomous University of Barcelona, Barcelona, Spain
Rodriguez-Jimenez R.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
CogPsy Group, Universidad Complutense de Madrid (UCM), Madrid, Spain
Roldán A.:
Psychiatry Department, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Pomarol-Clotet E.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Ibáñez A.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain
Usall J.:
Parc Sanitari Sant Joan de Déu, Teaching, Research & Innovation Unit, Institut de Recerca Sant Joan de Déu, Barcelona, Spain
García-Portilla M.P.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Universidad de Oviedo, Oviedo, Principality of Asturias, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Principality of Asturias, Spain Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Principality of Asturias, Spain Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Principality of Asturias, Oviedo, Spain
Cuesta M.J.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Parellada M.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
González-Pinto A.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Hospital Universitario de Alava, Vitoria, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Vitoria, Spain
BIOARABA Health Research Institute, Vitoria, Spain
Berrocoso E.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Neuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of Cádiz, Cádiz, Spain
Instituto de Investigación e Innovación Biomédica de Cádiz, INiBICA, Hospital Universitario Puerta del Mar, Cádiz, Spain
Bernardo M.:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Mas S.:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
González-Díaz J.M.:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
Arbelo N.:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
González-Peñas J.:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Pina-Camacho L.:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Diestre A.:
Psychiatry Department, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Selma J.:
Psychiatry Department, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Zorrilla I.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Hospital Universitario de Alava, Vitoria, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Vitoria, Spain
BIOARABA Health Research Institute, Vitoria, Spain
López P.:
Department of Psychiatry, Hospital Universitario de Alava, Vitoria, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Vitoria, Spain
BIOARABA Health Research Institute, Vitoria, Spain
Trabsa A.:
Institut de Neuropsiquiatria, Parc de Salut Mar, Cádiz, Spain
Monserrat C.:
Institut de Neuropsiquiatria, Parc de Salut Mar, Cádiz, Spain
Sanchez-Pastor L.:
Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Nuñez-Doyle A.:
Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Fatjó-Vilas M.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain
Sarró S.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Butjosa A.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Hospital Infanto-juvenil Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, CIBERSAM, Barcelona, Spain
Pardo M.:
Hospital Infanto-juvenil Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, CIBERSAM, Barcelona, Spain
López-Ilundain J.M.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Sánchez Torres A.M.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Saiz-Ruiz J.:
Department of Psychiatry, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain
Ochoa-Mangado E.:
Department of Psychiatry, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain
RIevero O.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Fundación Investigación Sanitaria INCLIVA
De-la-Cámara C.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Hospital Clínico Universitario and Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain
Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain
Echevarría R.S.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Cruces University Hospital, BioCruces Health Research Institute, University of the Basque Country (UPV/EHU) Vizcaya, Vizcaya, Spain
González-Blanco L.:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Barcelona, Spain
Department of Psychiatry, Universidad de Oviedo, Oviedo, Principality of Asturias, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Principality of Asturias, Spain Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Principality of Asturias, Spain Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Principality of Asturias, Oviedo, Spain
All Open Access, Hybrid Gold
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