Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension
Por:
del Campo, LSD, García-Redondo A.B., Rodríguez C., Zaragoza C., Duro-Sánchez S., Palmas F., De Benito-Bueno A., Socuéllamos P.G., Peraza D.A., Rodrigues-Díez R., Valenzuela C., Dalli J., Salaices M., Briones A.M.
Publicada:
1 ene 2023
Ahead of Print:
7 nov 2022
Resumen:
Background: Resolution of inflammation is orchestrated by specialized proresolving lipid mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among SPMs, resolvins (Rv) have beneficial effects in cardiovascular pathologies, but little is known about their effect on cardiovascular damage in hypertension. Methods: Aorta, small mesenteric arteries, heart, and peritoneal macrophages were taken from C57BL/6J mice, infused or not with angiotensin II (AngII; 1.44 mg/kg/day, 14 days) in presence or absence of resolvin D2 (RvD2) (100 ng/mice, every second day) starting 1 day before or 7 days after AngII infusion. Results: Enzymes and receptors involved in SPMs biosynthesis and signaling were increased in aorta or heart from AngII-infused mice. We also observed a differential regulation of SPMs in heart from these mice. Preventive treatment with RvD2 partially avoided AngII-induced hypertension and protected the heart and large and small vessels against functional and structural alterations induced by AngII. RvD2 increased the availability of vasoprotective factors, modified SPMs profile, decreased cardiovascular fibrosis, and increased the infiltration of pro-resolving macrophages. When administered in hypertensive animals with established cardiovascular damage, RvD2 partially improved cardiovascular function and structure, decreased fibrosis, reduced the infiltration of neutrophils, and shifted macrophage phenotype toward a pro-resolving phenotype. Conclusions: There is a disbalance between proinflammatory and resolution mediators in hypertension. RvD2 protects cardiovascular function and structure when administered before and after the development of hypertension by modulating vascular factors, fibrosis and inflammation. Activating resolution mechanisms by treatment with RvD2 may represent a novel therapeutic strategy for the treatment of hypertensive cardiovascular disease. © 2023 Lippincott Williams and Wilkins. All rights reserved.
Filiaciones:
del Campo, LSD:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
García-Redondo A.B.:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
Univ Autonoma Madrid, Dept Fisiol, Fac Med, Madrid, Spain
Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Madrid, Spain
CIBER Cardiovasc, Madrid, Spain
Rodríguez C.:
CIBER Cardiovasc, Madrid, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Zaragoza C.:
CIBER Cardiovasc, Madrid, Spain
Univ Francisco Vitoria, Unidad Invest Cardiovasc, Dept Cardiol, Hosp Ramon y Cajal IRYCIS, Madrid, Spain
Duro-Sánchez S.:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
Palmas F.:
Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Charterhouse Sq, London, England
De Benito-Bueno A.:
Inst Invest Biomed Alberto Sols CSIC UAM, Madrid, Spain
Socuéllamos P.G.:
Inst Invest Biomed Alberto Sols CSIC UAM, Madrid, Spain
Peraza D.A.:
Inst Invest Biomed Alberto Sols CSIC UAM, Madrid, Spain
Rodrigues-Díez R.:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Madrid, Spain
CIBER Cardiovasc, Madrid, Spain
Valenzuela C.:
CIBER Cardiovasc, Madrid, Spain
Inst Invest Biomed Alberto Sols CSIC UAM, Madrid, Spain
Dalli J.:
Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Charterhouse Sq, London, England
Queen Mary Univ London, Ctr Inflammat & Therapeut Innovat, London, England
Salaices M.:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Madrid, Spain
CIBER Cardiovasc, Madrid, Spain
Briones A.M.:
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain
Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Madrid, Spain
CIBER Cardiovasc, Madrid, Spain
Green Submitted, Bronze, All Open Access
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