Disrupted network switching in euthymic bipolar disorder: Working memory and self-referential paradigms
Por:
Porta-Casteràs D., Cano M., Navarra-Ventura G., Serra-Blasco M., Vicent-Gil M., Solé B., Montejo L., Torrent C., Martinez-Aran A., Harrison B.J., Palao D., Vieta E., Cardoner N.
Publicada:
1 ene 2023
Ahead of Print:
4 oct 2022
Resumen:
Background: Patients with bipolar disorder (BD) frequently suffer from neurocognitive deficits that can persist during periods of clinical stability. Specifically, impairments in executive functioning such as working memory and in self-processing have been identified as the main components of the neurocognitive profile observed in euthymic BD patients. The study of the neurobiological correlates of these state-independent alterations may be a prerequisite to develop reliable biomarkers in BD. Methods: A sample of 27 euthymic BD patients and 25 healthy participants (HC) completed working memory and self-referential functional Magnetic Resonance Imaging (fMRI) tasks. Activation maps obtained for each group and contrast images (i.e., 2-back > 1-back/self > control) were used for comparisons between patients and HC. Results: Euthymic BD patients, in comparison to HC, showed a higher ventromedial prefrontal cortex activation during working memory, a result driven by the lack of deactivation in BD patients. In addition, euthymic BD patients displayed a greater dorsomedial and dorsolateral prefrontal cortex activation during self-reference processing. Limitations: Pharmacotherapy was described but not included as a confounder in our models. Sample size was modest. Conclusion: Our findings revealed a lack of deactivation in the anterior default mode network (aDMN) during a working memory task, a finding consistent with prior research in BD patients, but also a higher activation in frontal regions within the central executive network (CEN) during self-processing. These results suggest that an imbalance of neural network dynamics underlying external/internal oriented cognition (the CEN and the aDMN, respectively) may be one of the first reliable biomarkers in euthymic bipolar patients. © 2022 Elsevier B.V.
Filiaciones:
Porta-Casteràs D.:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau IIB St Pau, Sant Pau Mental Hlth Res Grp, Barcelona, Spain
Parc Tauli Univ Hosp, Inst Invest & Innovacio Sanitaria Parc Tauli I3PT, Mental Hlth Dept, Unitat Neurociencia Traslac, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Cano M.:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau IIB St Pau, Sant Pau Mental Hlth Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Navarra-Ventura G.:
Hosp Univ Son Espases, Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca, Spain
Univ Illes Balears, Inst Univ Invest Ciencies Salut IUN, Palma De Mallorca, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Serra-Blasco M.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Inst Catal Oncol, Programa Ehlth ICOnnectat, Barcelona, Spain
Vicent-Gil M.:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau IIB St Pau, Sant Pau Mental Hlth Res Grp, Barcelona, Spain
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Solé B.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Montejo L.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Torrent C.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Martinez-Aran A.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Harrison B.J.:
Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Parkville, Vic, Australia
Palao D.:
Parc Tauli Univ Hosp, Inst Invest & Innovacio Sanitaria Parc Tauli I3PT, Mental Hlth Dept, Unitat Neurociencia Traslac, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Vieta E.:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Cardoner N.:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau IIB St Pau, Sant Pau Mental Hlth Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
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