Neuroplasticity and depression: First Depressive Episodes Studies (FIDEs)
Por:
Portella, MJ, De-Diego-Adelino, J, Perez-Egea, R, Puigdemont, D, Corripio, I, Pascual, JC, Soler, J, Gomez-Anson, B, Barbanoj, M, Alvarez, E, Perez, V
Publicada:
1 ene 2009
Resumen:
Neuronal plasticity may have a critical role in the pathophysiology of Major Depression. A variety of genetic, endocrine and environmental factors involved in the development of depressive disorder exert a high influence in neuroplasticity/neurogenesis processes. which in turn might be crucial in recovery from episodes and prognosis of the illness. We use the following prospective-longitudinal study with patients with a first episode of MDD. Included will be 30 patients matched with 30 healthy Subjects by age, gender and IQ. Four modules will be established: Clinical (demographic, and clinical variables): Neuroimaging (3T MR imaging acquisition): Neuropsychological (cognitive assessment) Biochemical (DNA extraction; BDNF plasma levels telomere length and telomerase activity salivary cortisol determination). There will be a baseline assessment and after 1 and 2 years. Expected results: To establish relation between how patients affected of a first episode of depression get access to the health care system and to specialized set-vices for early recognition and treatment and neurochemical, neuroanatomical and neuropsychosocial markers. The combination of different factors involved in the pathophysiology of depression will allow us to establish pragmatic models of prediction of the therapeutic response by neuropsychobiological profiles. Conclusions: Carrying out a project where the patients will be detected, diagnosed and treated at the very beginning of the illness will help on the one hand to determine what clinical, social or psychological variables might be related to antidepressant response, and on the other hand, this approach will reduce the costs of no treating the depressive episode as soon as possible.
Filiaciones:
Portella, MJ:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
De-Diego-Adelino, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Perez-Egea, R:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Puigdemont, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Corripio, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Pascual, JC:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Soler, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, CIBERSAM, Dept Psychiat, Barcelona 08025, Spain
Gomez-Anson, B:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Ctr Invest Medicaments, Dept Pharmacol, Barcelona 08025, Spain
Barbanoj, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neuroradiol, Barcelona 08025, Spain
Alvarez, E:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neuroradiol, Barcelona 08025, Spain
Perez, V:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neuroradiol, Barcelona 08025, Spain
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