Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
Por:
Font, MA, Fernandez, A, Carvajal, A, Gamez, C, Badimon, L, Slevin, M, Krupinski, J
Publicada:
1 ene 2009
Resumen:
It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R= 0.8 p<0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis ( R= 0.9 p<0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1; R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.
Filiaciones:
Font, MA:
HUB, Dept Neurol, Fundacio IDIBELL, Barcelona, Spain
Fernandez, A:
HUB, IDI, Fundacio Idibell, Barcelona, Spain
Carvajal, A:
HUB, Dept Neurol, Fundacio IDIBELL, Barcelona, Spain
Gamez, C:
HUB, IDI, Fundacio Idibell, Barcelona, Spain
Badimon, L:
Hosp Santa Creu & Sant Pau, Ctr Invest Cardiovasc, CSIC ICCC, Barcelona, Spain
Slevin, M:
Hosp Santa Creu & Sant Pau, Ctr Invest Cardiovasc, CSIC ICCC, Barcelona, Spain
Manchester Metropolitan Univ, Sch Biol Chem & Hlth Sci, Manchester M15 6BH, Lancs, England
Krupinski, J:
Hosp Mutua Terrassa, Dept Neurol, Terrassa 08221, Spain
HUB, Dept Neurol, Fundacio IDIBELL, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Ctr Invest Cardiovasc, CSIC ICCC, Barcelona, Spain
Green Accepted, Bronze
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