Normal values in ambulatory oesophageal pH monitoring at two levels in Spain
Por:
Azpiroz, F, Baudet, JS, Benages, A, Canga, F, Carrasco, J, Ciriza, C, Cucala, M, Dominguez, E, Faro, V, Garrigues, V, Giganto, F, Herrerias, JM, Iglesias, J, Lacima, G, Lopez, P, Llabres, M, Mearin, F, Minguez, M, Mones, J, Mora, F, Munoz, C, de la Sema, JP, Ponce, J, Rodriguez-Tellez, M, Romero, MJ, de Leon, AR, Ruiz-Cabello, M, Sanchez-Gey, S, Sanchiz, V, Serra, J, Sevilla, MC, Sopena, F, Soria, MJ
Publicada:
1 jul 2010
Resumen:
Aim: upper oesophageal pH monitoring may play a significant role in the study of extra-oesophageal GERD, but limited normal data are available to date. Our aim was to develop a large series of normal values of proximal oesophageal acidification.
Methods: 155 healthy volunteers (74 male) participated in a multi-centre national study including oesophageal manometry and 24 hours oesophageal pH monitoring using two electrodes individually located 5 cm above the LOS and 3 cm below the UOS.
Results: 130 participants with normal manometry completed all the study. Twelve of them were excluded for inadequate pH tests. Twenty-seven subjects had abnormal conventional pH. The remaining 91 subjects (37 M; 18-72 yrs age range) formed the reference group for normality. At the level of the upper oesophagus, the 955 percentile of the total number of reflux events was 30, after eliminating the meal periods 22, and after eliminating also the pseudo-reflux events 18. Duration of the longest episodes was 5, 4 and 4 min. respectively (3.5 min in upright and 0.5 min in supine). The upper limit for the percentage of acid exposure time was 1.35, 1.05 and 0.95%, respectively. No reflux events were recorded in the upper oesophagus in 8 cases.
Conclusion: this is the largest series of normal values of proximal oesophageal reflux that confirm the existence of acid reflux at that level in healthy subjects, in small quantity and unrelated to age or gender. Our data support the convenience of excluding pseudo-reflux events and meal periods from analysis.
Filiaciones:
Azpiroz, F:
Hosp Vail Hebron, Barcelona, Spain
Baudet, JS:
Hosp Nuestra Sra de la Candelaria, Santa Cruz De Tenerife, Spain
Benages, A:
Hosp Clin, Valencia, Spain
Canga, F:
Hosp 12 Octubre, E-28041 Madrid, Spain
Carrasco, J:
Hosp Univ Puerta Mar, Cadiz, Spain
Ciriza, C:
Hosp Bierzo, Leon, Spain
Cucala, M:
Novartis SA, Basel, Switzerland
Dominguez, E:
Univ Santiago de Compostela, Hosp Clin, La Coruna, Spain
Faro, V:
Hosp Ramon & Cajal, E-28034 Madrid, Spain
Garrigues, V:
Hosp La Fe, Valencia, Spain
Giganto, F:
Univ Oviedo, Hosp Cent Asturias, E-33080 Oviedo, Spain
Herrerias, JM:
Hosp Univ Virgen Macarena, Seville, Spain
Iglesias, J:
Univ Santiago de Compostela, Hosp Clin, La Coruna, Spain
Lacima, G:
Hosp Clin Barcelona, Barcelona, Spain
Lopez, P:
Hosp Aranzazu, Donosti, Spain
Llabres, M:
Hosp Son Dureta, Palma de Mallorca, Spain
Mearin, F:
Ctr Med Teknon, Barcelona, Spain
Minguez, M:
Hosp Clin, Valencia, Spain
Mones, J:
Hosp Sant Pau, Barcelona, Spain
Mora, F:
Hosp Clin Univ, Valencia, Spain
Munoz, C:
Hosp Virgen Blanca, Toledo, OH USA
de la Sema, JP:
Hosp Clin San Carlos, Madrid, Spain
Ponce, J:
Hosp La Fe, Valencia, Spain
Rodriguez-Tellez, M:
Hosp Univ Virgen Macarena, Seville, Spain
Romero, MJ:
Hosp Bierzo, Leon, Spain
de Leon, AR:
Hosp Clin San Carlos, Madrid, Spain
Ruiz-Cabello, M:
Hosp Univ Virgen de las Nieves, Granada, Spain
Sanchez-Gey, S:
Hosp Univ Virgen Macarena, Seville, Spain
Sanchiz, V:
Hosp Clin, Valencia, Spain
Serra, J:
Hosp Vail Hebron, Barcelona, Spain
Sevilla, MC:
Hosp Clin San Carlos, Madrid, Spain
Sopena, F:
Univ Zaragoza, Hosp Clin, E-50009 Zaragoza, Spain
Soria, MJ:
Hosp Univ Puerta Mar, Cadiz, Spain
Green Published, gold
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