The risk of second primary tumors in head and neck cancer: A systematic review
Por:
Coca-Pelaz, A, Rodrigo, JP, Suarez, C, Nixon, IJ, Makitie, A, Sanabria, A, Quer, M, Strojan, P, Bradford, CR, Kowalski, LP, Shaha, AR, de Bree, R, Hartl, DM, Rinaldo, A, Takes, RP, Ferlito, A
Publicada:
1 mar 2020
Ahead of Print:
1 nov 2019
Resumen:
Background Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.
Filiaciones:
Coca-Pelaz, A:
Univ Oviedo, Dept Otolaryngol, Hosp Univ Cent Asturias, Oviedo, Spain
CIBERONC, IUOPA, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Rodrigo, JP:
Univ Oviedo, Dept Otolaryngol, Hosp Univ Cent Asturias, Oviedo, Spain
CIBERONC, IUOPA, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Suarez, C:
CIBERONC, IUOPA, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Nixon, IJ:
Univ Edinburgh, NHS Lothian, Ear Nose & Throat Dept, Edinburgh, Midlothian, Scotland
Makitie, A:
Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland
Helsinki Univ Hosp, Helsinki, Finland
Sanabria, A:
Univ Antioquia, Sch Med, Dept Surg, CEXCA Ctr Excelencia Enfermedades Cabeza & Cuello, Medellin, Colombia
Quer, M:
Hosp Santa Creu & Sant Pau, Dept Otolaryngol, Barcelona, Spain
Strojan, P:
Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia
Bradford, CR:
Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA
Kowalski, LP:
AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, SP, Brazil
Shaha, AR:
Mem Sloan Kettering Canc Ctr, Head & Neck Serv, 1275 York Ave, New York, NY 10021 USA
de Bree, R:
Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands
Hartl, DM:
Inst Gustave Roussy, Dept Otolaryngol Head & Neck Surg, Villejuif, France
Lab Phonet & Phonol, Paris, France
Rinaldo, A:
Univ Udine, Sch Med, Udine, Italy
Takes, RP:
Radboud Univ Nijmegen, Dept Otolaryngol Head & Neck Surg, Med Ctr, Nijmegen, Netherlands
Ferlito, A:
Int Head & Neck Sci Grp Padua, Padua, Italy
Green Published
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