Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort
Por:
Mas, S, Gasso, P, Rodriguez, N, Cabrera, B, Mezquida, G, Lobo, A, Gonzalez-Pinto, A, Parellada, M, Corripio, I, Vieta, E, Castro-Fornieles, J, Bobes, J, Usall, J, Saiz-Ruiz, J, Contreras, F, Parellada, E, Bernardo, M, Lafuente, A, Bioque, M, Diaz-Caneja, CM, Gonzalez-Penas, J, Solis, AA, Rebella, M, Gonzalez-Ortega, I, Besga, A, SanJuan, J, Nacher, J, Morro, L, Montserrat, C, Jimenez, E, Da Costa, SG, Baeza, I, de la Serna, E, Rivas, S, Diaz, C, Saiz, PA, Garcia-Alvarez, L, Fraile, MG, Rabadan, AZ, Torio, I, Rodriguez-Jimenez, R, Butjosa, A, Pardo, M, Sarro, S, Pomarol-Clotet, E, Cuadrado, AI, Cuesta, MJ
Publicada:
1 jun 2020
Ahead of Print:
1 dic 2019
Resumen:
Aims Here, we present a clustering strategy to identify phenotypes of antipsychotic (AP) response by using longitudinal data from patients presenting first-episode psychosis (FEP). Method One hundred and ninety FEP with complete data were selected from the PEPs project. The efficacy was assessed using total PANSS, and adverse effects using total UKU, during one-year follow-up. We used the Klm3D method to cluster longitudinal data. Results We identified four clusters: cluster A, drug not toxic and beneficial; cluster B, drug beneficial but toxic; cluster C, drug neither toxic nor beneficial; and cluster D, drug toxic and not beneficial. These groups significantly differ in baseline demographics, clinical, and neuropsychological characteristics (PAS, total PANSS, DUP, insight, pIQ, age of onset, cocaine use and family history of mental illness). Conclusions The results presented here allow the identification of phenotypes of AP response that differ in well-known simple and classic clinical variables opening the door to clinical prediction and application of personalized medicine.
Filiaciones:
Mas, S:
Univ Barcelona, Dept Clin Foundat, Pharmacol Unit, Barcelona, Spain
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Gasso, P:
Univ Barcelona, Dept Clin Foundat, Pharmacol Unit, Barcelona, Spain
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Rodriguez, N:
FCRB, Barcelona, Spain
Cabrera, B:
CIBERSAM, Barcelona, Spain
Neurosci Inst Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Mezquida, G:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, FCRB, Dept Clin Foundat, Barcelona, Spain
Lobo, A:
IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
CIBERSAM, Barcelona, Spain
Hosp Univ Alava, Dept Psychiat, Vitoria, Spain
BIOARABA Hlth Res Inst, Vitoria, Spain
Univ Basque Country, Vitoria, Spain
Parellada, M:
CIBERSAM, Barcelona, Spain
Univ Complutense, IiSGM, CIBERSAM, Univ Gregorio Maranon,Sch Med, Madrid, Spain
Corripio, I:
CIBERSAM, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Serv Psiquiat, Barcelona, Spain
IIBSANT PAU, Barcelona, Spain
UAB, Barcelona, Spain
Vieta, E:
CIBERSAM, Barcelona, Spain
Hosp Clin Barcelona, Barcelona, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Child & Adolescent Psychiat & Psychol Dept 2017, Barcelona, Spain
Castro-Fornieles, J:
CIBERSAM, Barcelona, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Child & Adolescent Psychiat & Psychol Dept 2017, Barcelona, Spain
Univ Oviedo, HUCA, Area Psiquiatria, Asturias, Spain
Bobes, J:
CIBERSAM, Barcelona, Spain
ISPA, Asturias, Spain
Univ Alcala De Henares, IRYCIS, CIBERSAM, Madrid, Spain
Usall, J:
Hospitalet Llobregat, Bellvitge Univ Hosp, Psychiat Serv, Barcelona, Spain
Univ Barcelona, Barcelona, Spain
Saiz-Ruiz, J:
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Contreras, F:
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Parellada, E:
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Child & Adolescent Psychiat & Psychol Dept 2017, Barcelona, Spain
Bernardo, M:
CIBERSAM, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Inst Clin Neurosci, Child & Adolescent Psychiat & Psychol Dept 2017, Barcelona, Spain
Lafuente, A:
Univ Barcelona, Dept Clin Fdn, Barcelona, Spain
Bioque, M:
Univ Barcelona, Dept Med, CIBERSAM,IDIBAPS, Neurosci Inst,Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Gonzalez-Penas, J:
Hosp Gen Univ Gregorio, Child & Adolescent Psychiat Dept, Maracaibo, Venezuela
Solis, AA:
UAB, Hosp Santa Creu Sant Pau, IIB SANT PAU, Barcelona, Spain
Rebella, M:
Hosp Univ Alava, Dept Psychiat, Vitoria, Spain
Univ Basque Country, BIOARABA, CIBERSAM, Vitoria, Spain
SanJuan, J:
Univ Valencia, Hosp Clin Univ, Valencia, Spain
Univ Valencia, Hosp Clin Univ, INCLIVA, Fdn Invest, Valencia, Spain
Nacher, J:
BIOTECMED, Neurobiol Unit, Program Neurosci & Interdisciplinary Res Str, Valencia, Spain
Univ Valencia, BIOTECMED, Burjassot, Spain
Jimenez, E:
INCLIVA, Spain CIBERSAM, Valencia, Spain
Da Costa, SG:
Univ Barcelona, Dept Med, CIBERSAM, IDIBAPs, Barcelona, Spain
de la Serna, E:
Hosp Clin Barcelona, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Saiz, PA:
Univ Oviedo, Area Psiquiat, Oviedo, Spain
Fraile, MG:
Univ Basque Country, UPV EHU, Hosp Bioaraba Res Inst, Madrid, Spain
Rabadan, AZ:
Univ Basque Country, Dept Neurosci, CIBERSAM, BioCruces Hlth Res Inst, Vizcaya, Spain
Butjosa, A:
Inst Invest Sanitaria Hosp 12 Octubre, Madrid, Spain
Pardo, M:
Hosp San Juan Dios, Child & Adolescent Psychiat & Psychol Dept, Inst Recerca Sant Joan Deu, Madrid, Spain
Pomarol-Clotet, E:
FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain
Cuadrado, AI:
Univ Alcala De Henares, IRYCIS, CIBERSAM, Hosp Ramon & Cajal, Madrid, Spain
Cuesta, MJ:
Complejo Hosp Navarra, IdiSNa, Navarra, Spain
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