Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression
Por:
Ballarin, J, Arce, Y, Balcells, RT, Encarnacion, MD, Manzarbeitia, F, Ortiz, A, Egido, J, Moreno, JA
Publicada:
1 oct 2011
Resumen:
Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.
Filiaciones:
Ballarin, J:
Univ Autonoma Barcelona, Dept Nephrol, Fdn Puigvert, Hosp Santa Creu & Sant Pau, E-08193 Barcelona, Spain
Arce, Y:
Fdn Puigvert, Dept Pathol, Barcelona, Spain
Balcells, RT:
Univ Autonoma Barcelona, Dept Nephrol, Fdn Puigvert, Hosp Santa Creu & Sant Pau, E-08193 Barcelona, Spain
Encarnacion, MD:
Univ Autonoma Barcelona, Dept Nephrol, Fdn Puigvert, Hosp Santa Creu & Sant Pau, E-08193 Barcelona, Spain
Manzarbeitia, F:
IIS Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain
Ortiz, A:
Univ Autonoma Madrid, Dept Nephrol, IIS Fdn Jimenez Diaz, Madrid, Spain
Egido, J:
Univ Autonoma Madrid, Dept Nephrol, IIS Fdn Jimenez Diaz, Madrid, Spain
Moreno, JA:
Univ Autonoma Madrid, Dept Nephrol, IIS Fdn Jimenez Diaz, Madrid, Spain
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