Optimized clinical management of Parkinson's disease with opicapone. Recommendations from Spanish experts
Por:
Linazasoro-Cristobal, G, del Val, LJL, Ruiz-Espiga, PG, Lopez-Manzanares, L, Luquin-Piudo, MR, Martinez-Castrillo, JC, Mir, P, Pagonabarraga-Mora, J
Publicada:
1 ene 2020
Resumen:
Motor fluctuations are frequently seen in Parkinson disease patients on chronic treatment with levodopa. Management of motor fluctuation includes the addition of catechol-O-methyl transferase (COMT) inhibitors. Opicapone is a recent and selective third-generation COMT inhibitor which achieves marked increase in the bioavailability of levodopa. We present a consensus of a group of Spanish neurologists with extensive experience in the clinical management of motor fluctuations. The clinical experience of this group of experts is in line with clinical trials and confirms that opicapone is an effective drug in the control of motor fluctuations, regardless of the daily levodopa dose, or the use of other antiparkinsonian drugs. However, in the opinion of these experts, the ideal patient with Parkinson's disease to initiate treatment with opicapone is the one with mild motor fluctuations, since the ratio between clinical efficacy and adverse effects is more favorable. In general, it is an easy-to-use drug both in those first treated with a COMT inhibitor or those already on entacapone. In any case, the secondary side effects are easily managed.
Filiaciones:
Linazasoro-Cristobal, G:
VIVEbiotech SL, Policlin Gipuzkoa, Adv Therapy Programme Parkinsons & Alzheimer, San Sebastian, Spain
del Val, LJL:
Hosp Clin Montpellier, Grp HLA, Inst Invest Sanitaria Aragon, Movement Disorders Unit, Zaragoza, Spain
Ruiz-Espiga, PG:
Fdn Jimenez Diaz, Neurol Serv, Madrid, Spain
Lopez-Manzanares, L:
Hosp Univ La Princesa, Serv Neurol, Movement Disorders Unit, Madrid, Spain
Luquin-Piudo, MR:
Clin Univ Navarra, Neurol Serv, Pamplona, Navarra, Spain
Martinez-Castrillo, JC:
Hosp Univ Ramon y Cajal, IRYCIS, Serv Neurol, Movement Disorders Unit, Madrid, Spain
Mir, P:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,Movement Disorders Unit,Serv, Seville, Spain
Pagonabarraga-Mora, J:
Hosp Santa Creu & Sant Pau, Neurol Serv, Barcelona, Spain
|