Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010


Por: Vos, T, Flaxman, AD, Naghavi, M, Lozano, R, Michaud, C, Ezzati, M, Shibuya, K, Salomon, JA, Abdalla, S, Aboyans, V, Abraham, J, Ackerman, I, Aggarwal, R, Ahn, SY, Ali, MK, Alvarado, M, Anderson, HR, Anderson, LM, Andrews, KG, Atkinson, C, Baddour, LM, Bahalim, AN, Barker-Collo, S, Barrero, LH, Bartels, DH, Basanez, MG, Baxter, A, Bell, ML, Benjamin, EJ, Bennett, D, Bernabe, E, Bhalla, K, Bhandari, B, Bikbov, B, Bin Abdulhak, A, Birbeck, G, Black, JA, Blencowe, H, Blore, JD, Blyth, F, Bolliger, I, Bonaventure, A, Boufous, SA, Bourne, R, Boussinesq, M, Braithwaite, T, Brayne, C, Bridgett, L, Brooker, S, Brooks, P, Brugha, TS, Bryan-Hancock, C, Bucello, C, Buchbinder, R, Buckle, GR, Budke, CM, Burch, M, Burney, P, Burstein, R, Calabria, B, Campbell, B, Canter, CE, Carabin, H, Carapetis, J, Carmona, L, Cella, C, Charlson, F, Chen, HL, Cheng, ATA, Chou, D, Chugh, SS, Coffeng, LE, Colan, SD, Colquhoun, S, Colson, KE, Condon, J, Connor, MD, Cooper, LT, Corriere, M, Cortinovis, M, de Vaccaro, KC, Couser, W, Cowie, BC, Criqui, MH, Cross, M, Dabhadkar, KC, Dahiya, M, Dahodwala, N, Damsere-Derry, J, Danaei, G, Davis, A, De Leo, D, Degenhardt, L, Dellavalle, R, Delossantos, A, Denenberg, J, Derrett, S, Des Jarlais, DC, Dharmaratne, SD, Dherani, M, Diaz-Torne, C, Dolk, H, Dorsey, ER, Driscoll, T, Duber, H, Ebel, B, Edmond, K, Elbaz, A, Ali, SE, Erskine, H, Erwin, PJ, Espindola, P, Ewoigbokhan, SE, Farzadfar, F, Feigin, V, Felson, DT, Ferrari, A, Ferri, CP, Fevre, EM, Finucane, MM, Flaxman, S, Flood, L, Foreman, K, Forouzanfar, MH, Fowkes, FGR, Franklin, R, Fransen, M, Freeman, MK, Gabbe, BJ, Gabriel, SE, Gakidou, E, Ganatra, HA, Garcia, B, Gaspari, F, Gillum, RF, Gmel, G, Gosselin, R, Grainger, R, Groeger, J, Guillemin, F, Gunnell, D, Gupta, R, Haagsma, J, Hagan, H, Halasa, YA, Hall, W, Haring, D, Haro, JM, Harrison, JE, Havmoeller, R, Hay, RJ, Higashi, H, Hill, C, Hoen, B, Hoffman, H, Hotez, PJ, Hoy, D, Huang, JJ, Ibeanusi, SE, Jacobsen, KH, James, SL, Jarvis, D, Jasrasaria, R, Jayaraman, S, Johns, N, Jonas, JB, Karthikeyan, G, Kassebaum, N, Kawakami, N, Keren, A, Khoo, JP, King, CH, Knowlton, LM, Kobusingye, O, Koranteng, A, Krishnamurthi, R, Lalloo, R, Laslett, LL, Lathlean, T, Leasher, JL, Lee, YY, Leigh, J, Lim, SS, Limb, E, Lin, JK, Lipnick, M, Lipshultz, SE, Liu, W, Loane, M, Ohno, SL, Lyons, R, Ma, JX, Mabweijano, J, MacIntyre, MF, Malekzadeh, R, Mallinger, L, Manivannan, S, Marcenes, W, March, L, Margolis, DJ, Marks, GB, Marks, R, Matsumori, A, Matzopoulos, R, Mayosi, BM, McAnulty, JH, McDermott, MM, McGill, N, McGrath, J, Medina-Mora, ME, Meltzer, M, Mensah, GA, Merriman, TR, Meyer, AC, Miglioli, V, Miller, M, Miller, TR, Mitchell, PB, Mocumbi, AO, Moffitt, TE, Mokdad, AA, Monasta, L, Montico, M, Moradi-Lakeh, M, Moran, A, Morawska, L, Mori, R, Murdoch, ME, Mwaniki, MK, Naidoo, K, Nair, MN, Naldi, L, Narayan, KMV, Nelson, PK, Nelson, RG, Nevitt, MC, Newton, CR, Nolte, S, Norman, P, Norman, R, O'Donnell, M, O'Hanlon, S, Olives, C, Omer, SB, Ortblad, K, Osborne, R, Ozgediz, D, Page, A, Pahari, B, Pandian, JD, Rivero, AP, Patten, SB, Pearce, N, Padilla, RP, Perez-Ruiz, F, Perico, N, Pesudovs, K, Phillips, D, Phillips, MR, Pierce, K, Pion, S, Polanczyk, GV, Polinder, S, Pope, CA, Popova, S, Porrini, E, Pourmalek, F, Prince, M, Pullan, RL, Ramaiah, KD, Ranganathan, D, Razavi, H, Regan, M, Rehm, JT, Rein, DB, Remuzzi, G, Richardson, K, Rivara, FP, Roberts, T, Robinson, C, De Leon, FR, Ronfani, L, Room, R, Rosenfeld, LC, Rushton, L, Sacco, RL, Saha, S, Sampson, U, Sanchez-Riera, L, Sanman, E, Schwebel, DC, Scott, JG, Segui-Gomez, M, Shahraz, S, Shepard, DS, Shin, H, Shivakoti, R, Singh, D, Singh, GM, Singh, JA, Singleton, J, Sleet, DA, Sliwa, K, Smith, E, Smith, JL, Stapelberg, NJC, Steer, A, Steiner, T, Stolk, WA, Stovner, LJ, Sudfeld, C, Syed, S, Tamburlini, G, Tavakkoli, M, Taylor, HR, Taylor, JA, Taylor, WJ, Thomas, B, Thomson, WM, Thurston, GD, Tleyjeh, IM, Tonelli, M, Towbin, JRA, Truelsen, T, Tsilimbaris, MK, Ubeda, C, Undurraga, EA, van der Werf, MJ, van Os, J, Vavilala, MS, Venketasubramanian, N, Wang, MR, Wang, WZ, Watt, K, Weatherall, DJ, Weinstock, MA, Weintraub, R, Weisskopf, MG, Weissman, MM, White, RA, Whiteford, H, Wiersma, ST, Wilkinson, JD, Williams, HC, Williams, SRM, Witt, E, Wolfe, F, Woolf, AD, Wulf, S, Yeh, PH, Zaidi, AKM, Zheng, ZJ, Zonies, D, Lopez, AD, Murray, CJL

Publicada: 15 dic 2012
Resumen:
Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0.37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.

Filiaciones:
Vos, T:
 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

Flaxman, AD:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Naghavi, M:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Lozano, R:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Michaud, C:
 China Med Board, Boston, MA USA

Ezzati, M:
 Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London, England

Shibuya, K:
 Univ Tokyo, Dept Global Hlth Policy, Tokyo, Japan

Salomon, JA:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Aboyans, V:
 Dupuytren Univ Hosp, Dept Cardiol, Limoges, France

Abraham, J:
 Univ Texas San Antonio, San Antonio, TX USA

Aggarwal, R:
 Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India

Ahn, SY:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Alvarado, M:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Anderson, HR:
 St Georges Univ London, London, England

Anderson, LM:
 Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98121 USA

Andrews, KG:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Mayo Clin, Rochester, MN USA

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 Univ Auckland, Auckland 1, New Zealand

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 Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia

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 Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA

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 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

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 Yale Univ, New Haven, CT USA

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 Univ Oxford, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Epidemiol Studies Unit, Oxford, England

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 Kings Coll London, Inst Dent, London WC2R 2LS, England

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 Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA

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 Moscow State Univ Med & Dent, Res Inst Transplantol & Artificial Organs, Moscow, Russia

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 Michigan State Univ, E Lansing, MI 48824 USA

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 MRC, Epidemiol Unit, Cambridge, England

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 Moorfields Eye Hosp, London, England

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 Univ Edinburgh, Edinburgh, Midlothian, Scotland

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 Loyola Univ, Sch Med, Chicago, IL 60611 USA

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 Wake Forest Univ, Sch Publ Hlth Sci, Winston Salem, NC 27109 USA

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 Univ Calif San Diego, San Diego, CA 92103 USA

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 Queen Mary Univ London, Inst Dent, London, England

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 Univ Penn, Philadelphia, PA 19104 USA

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 Bldg & Rd Res Inst, Kumasi, Ghana

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 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

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 MRC Hearing & Commun Grp, Manchester, Lancs, England

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 Univ Melbourne, Ctr Hlth Policy Programs & Econ, Melbourne, Vic, Australia

 Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

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 Denver VA Med Ctr, Denver, CO USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Univ Calif San Diego, San Diego, CA 92103 USA

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 Univ Otago, Dunedin, New Zealand

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 Beth Israel Deaconess Med Ctr, New York, NY 10003 USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

 Univ Peradeniya, Peradeniya, Sri Lanka

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 Univ Liverpool, Liverpool L69 3BX, Merseyside, England

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 Hosp Santa Creu & Sant Pau, Barcelona, Spain

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 Univ Ulster, Ulster, Ireland

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 Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia

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 London Sch Hyg & Trop Med, London WC1, England

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 INSERM, Paris, France

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 Fed Minist Hlth, Khartoum, Sudan

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 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

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 Mayo Clin, Rochester, MN USA

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 Hosp Maciel, Montevideo, Uruguay

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 Emerald Publ Hlth Consulting Serv Ltd, Abuja, Nigeria

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 Auckland Tech Univ, Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand

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 Boston Univ, Sch Med, Boston, MA 02118 USA

Ferrari, A:
 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

Finucane, MM:
 Harvard Univ, Dept Biostat, Boston, MA 02115 USA

Flaxman, S:
 Carnegie Mellon Univ, Pittsburgh, PA 15213 USA

Flood, L:
 Flinders Univ S Australia, Adelaide, SA 5001, Australia

Forouzanfar, MH:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Fowkes, FGR:
 Univ Edinburgh, Edinburgh, Midlothian, Scotland

Franklin, R:
 Royal Life Saving Soc, Sydney, NSW, Australia

 James Cook Univ, Townsville, Qld 4811, Australia

Fransen, M:
 Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia

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 Mayo Clin, Rochester, MN USA

Gakidou, E:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Gaspari, F:
 Mario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy

Gillum, RF:
 Howard Univ, Coll Med, Washington, DC USA

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 Addict Info Switzerland, Lausanne, Switzerland

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 Univ Otago, Dunedin, New Zealand

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 Suny Downstate Med Ctr, Coll Med, Brooklyn, NY 11203 USA

Guillemin, F:
 Univ Lorraine, Nancy, France

Gunnell, D:
 Univ Bristol, Bristol, Avon, England

Gupta, R:
 St Georges Univ London, London, England

Hagan, H:
 NYU, New York, NY USA

Halasa, YA:
 Brandeis Univ, Waltham, MA USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Haro, JM:
 Univ Barcelona, CIBERSAM, St Bio De Llobregat, Spain

Harrison, JE:
 Flinders Univ S Australia, Adelaide, SA 5001, Australia

Havmoeller, R:
 Cedars Sinai Med Ctr, Inst Heart, Los Angeles, CA 90048 USA

 Karolinska Univ Hosp, Stockholm, Sweden

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 Kings Coll London, Hosp NHS Trust, London WC2R 2LS, England

Higashi, H:
 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

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 Queen Elizabeth Hosp, Adelaide, SA, Australia

Hoen, B:
 Univ Franche Comte, F-25030 Besancon, France

 Ctr Hosp Reg Univ Besancon, Besancon, France

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 NIDCD, NIH, Bethesda, MD USA

Hotez, PJ:
 Baylor Coll Med, Natl Sch Trop Med, Waco, TX USA

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 Yale Univ, New Haven, CT USA

Ibeanusi, SE:
 Univ Port Harcourt, Port Harcourt, Nigeria

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 George Mason Univ, Fairfax, VA 22030 USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Harvard Univ, Brigham & Womens Hosp, Boston, MA 02115 USA

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

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 Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany

Karthikeyan, G:
 All India Inst Med Sci, New Delhi, India

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 Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98121 USA

Keren, A:
 Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Cardiol, IL-91010 Jerusalem, Israel

Khoo, JP:
 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

King, CH:
 Case Western Reserve Univ, Cleveland, OH 44106 USA

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 Harvard Univ, Harvard Humanitarian Initiat, Boston, MA 02115 USA

Kobusingye, O:
 Makerere Univ, Sch Publ Hlth, Kampala, Uganda

 Univ S Africa, Johannesburg, South Africa

Koranteng, A:
 Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana

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 Griffith Univ, Sch Dent & Oral Hlth, Brisbane, Qld 4111, Australia

 Griffith Univ, Populat & Social Hlth Res Program, Brisbane, Qld 4111, Australia

Laslett, LL:
 Univ Tasmania, Hobart, Tas 7001, Australia

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 Flinders Univ S Australia, Adelaide, SA 5001, Australia

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 Nova SE Univ, Ft Lauderdale, FL 33314 USA

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 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

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 Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Limb, E:
 St Georges Univ London, London, England

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 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Lipshultz, SE:
 Univ Miami, Miller Sch Med, Miami, FL 33136 USA

Liu, W:
 Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA

Loane, M:
 Univ Ulster, Ulster, Ireland

Ohno, SL:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Lyons, R:
 Swansea Univ, Swansea, W Glam, Wales

Ma, JX:
 China Ctr Dis Control, Natl Ctr Noncommunicable Dis Control & Prevent, Beijing, Peoples R China

Mabweijano, J:
 Mulago Hosp, Kampala, Uganda

MacIntyre, MF:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Malekzadeh, R:
 Univ Tehran Med Sci, Digest Dis Res Ctr, Tehran, Iran

Mallinger, L:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Manivannan, S:
 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

March, L:
 Univ Sydney, Inst Bone & Joint Res, Sydney, NSW 2006, Australia

Margolis, DJ:
 Univ Penn, Philadelphia, PA 19104 USA

Matsumori, A:
 Asian Pacific Soc Cardiol, Kyoto, Japan

Matzopoulos, R:
 MRC, Tygerberg, South Africa

McAnulty, JH:
 Legacy Hlth Syst, Portland, OR USA

McDermott, MM:
 Northwestern Univ, Feinberg Sch Med, Evanston, IL USA

McGrath, J:
 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

Medina-Mora, ME:
 Natl Inst Psychiat Ramon de la Fuente, Mexico City, DF, Mexico

Meltzer, M:
 Thomas Jefferson Univ, Philadelphia, PA 19107 USA

Mensah, GA:
 Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa

Merriman, TR:
 Univ Otago, Dunedin, New Zealand

Miglioli, V:
 Mario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy

Miller, M:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Miller, TR:
 Pacific Inst Res & Evaluat, Calverton, MD USA

Mitchell, PB:
 Univ New S Wales, Sydney, NSW, Australia

Mocumbi, AO:
 Natl Inst Hlth, Maputo, Mozambique

 Univ Eduardo Mondlane, Maputo, Mozambique

Moffitt, TE:
 Duke Univ, Durham, NC USA

Mokdad, AA:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Monasta, L:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Montico, M:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Morawska, L:
 Queensland Univ Technol, Brisbane, Qld 4001, Australia

Mori, R:
 Natl Ctr Child Hlth & Dev, Tokyo, Japan

Murdoch, ME:
 Watford Dist Gen Hosp, Watford, England

Mwaniki, MK:
 Kemri Wellcome Trust, Kilifi, Kenya

Naidoo, K:
 Univ KwaZulu Natal, AVRI, Durban, South Africa

Nair, MN:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Naldi, L:
 Ctr Studi GISED, Bergamo, Italy

Nelson, PK:
 Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

Nelson, RG:
 NIDDK, NIH, Bethesda, MD USA

Nevitt, MC:
 Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

Nolte, S:
 Charite, D-13353 Berlin, Germany

Norman, R:
 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

O'Donnell, M:
 Natl Univ Ireland Galway, HRB Clin Res Facil, Galway, Ireland

Omer, SB:
 Emory Univ, Sch Publ Hlth, Atlanta, GA USA

 Emory Univ, Sch Med, Atlanta, GA USA

Ortblad, K:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Osborne, R:
 Deakin Univ, Melbourne, Vic, Australia

Ozgediz, D:
 Yale Univ, New Haven, CT USA

Page, A:
 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

Pahari, B:
 BP Koirala Inst Hlth Sci, Dharan, Nepal

Pandian, JD:
 Betty Cowan Res & Innovat Ctr, Ludhiana, Punjab, India

Rivero, AP:
 Hosp Joan 23, La Paz, Bolivia

Patten, SB:
 Univ Calgary, Calgary, AB, Canada

Pearce, N:
 London Sch Hyg & Trop Med, London WC1, England

Padilla, RP:
 Inst Nacl Enfermedades Resp, Mexico City, DF, Mexico

Perez-Ruiz, F:
 Hosp Univ Cruces, Baracaldo, Spain

Perico, N:
 Mario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy

Pesudovs, K:
 Flinders Univ S Australia, Adelaide, SA 5001, Australia

Phillips, D:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Phillips, MR:
 Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China

Pierce, K:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Polanczyk, GV:
 Univ Fed Sao Paulo, Sch Med, Sao Paulo, Brazil

Polinder, S:
 Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands

Pope, CA:
 Brigham Young Univ, Provo, UT 84602 USA

Popova, S:
 Ctr Addict & Mental Hlth, Toronto, ON, Canada

Porrini, E:
 Hosp Univ Canarias, Tenerif, Spain

Pourmalek, F:
 Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada

Prince, M:
 Kings Coll London, Inst Psychiat, London WC2R 2LS, England

Pullan, RL:
 London Sch Hyg & Trop Med, London WC1, England

Ramaiah, KD:
 Vector Control Res Ctr, Pondicherry, India

Ranganathan, D:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Razavi, H:
 Ctr Dis Anal, Louisville, CO USA

Regan, M:
 Univ Calif Berkeley, Berkeley, CA 94720 USA

Rehm, JT:
 Ctr Addict & Mental Hlth, Toronto, ON, Canada

Rein, DB:
 Univ Chicago, NORC, Chicago, IL 60637 USA

Remuzzi, G:
 Mario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy

Richardson, K:
 Univ Cambridge, Cambridge, England

Roberts, T:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

De Leon, FR:
 Complejo Hosp Caja Seguro Social, Panama City, Panama

Ronfani, L:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Room, R:
 Univ Melbourne, Sch Populat Hlth, Melbourne, Vic, Australia

 Turning Point Alcohol & Drug Ctr, Ctr Alcohol Policy Res, Fitzroy, SA, Australia

Rosenfeld, LC:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Sacco, RL:
 Univ Miami, Miller Sch Med, Miami, FL 33136 USA

Saha, S:
 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

Sampson, U:
 Vanderbilt Univ, Nashville, TN USA

Sanchez-Riera, L:
 Univ Sydney, Inst Bone & Joint Res, Sydney, NSW 2006, Australia

Sanman, E:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Schwebel, DC:
 Univ Alabama Birmingham, Birmingham, AL USA

Scott, JG:
 Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia

Segui-Gomez, M:
 Minist Interior, Madrid, Spain

Shahraz, S:
 Brandeis Univ, Waltham, MA USA

Shepard, DS:
 Brandeis Univ, Waltham, MA USA

Shin, H:
 Hlth Canada, Ottawa, ON K1A 0L2, Canada

Singh, D:
 Queens Med Ctr, Honolulu, HI USA

Singh, GM:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Singh, JA:
 Univ Alabama Birmingham, Birmingham, AL USA

Singleton, J:
 Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

Sleet, DA:
 Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA

Sliwa, K:
 Univ Cape Town, Hatter Inst, ZA-7925 Cape Town, South Africa

Smith, E:
 Univ Sydney, No Clin Sch, Dept Rheumatol, Sydney, NSW 2006, Australia

Smith, JL:
 London Sch Hyg & Trop Med, London WC1, England

Steer, A:
 Univ Melbourne, Ctr Int Child Hlth, Melbourne, Vic, Australia

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 Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway

Sudfeld, C:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Syed, S:
 Agwa Khan Univ, Karachi, Pakistan

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 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Tavakkoli, M:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Taylor, JA:
 Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA

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 Univ Otago, Dunedin, New Zealand

Thomson, WM:
 Univ Otago, Dunedin, New Zealand

Thurston, GD:
 NYU, New York, NY USA

Tleyjeh, IM:
 King Fahad Med City, Riyadh, Saudi Arabia

Tonelli, M:
 Univ Alberta, Alberta Kidney Dis Network, Edmonton, AB, Canada

Towbin, JRA:
 Cincinnati Childrens Hosp, Cincinnati, OH USA

Truelsen, T:
 Copenhagen Univ Hosp, Dept Neurol, Herlev, Denmark

Tsilimbaris, MK:
 Univ Crete, Sch Med, Iraklion, Greece

Ubeda, C:
 ANLIS, Inst Nacl Epidemiol, Malbran, Argentina

Undurraga, EA:
 Brandeis Univ, Waltham, MA USA

van der Werf, MJ:
 KNCV TB Fdn, The Hague, Netherlands

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 Maastricht Univ Med Ctr, Maastricht, Netherlands

Venketasubramanian, N:
 Natl Univ Singapore, Singapore 117548, Singapore

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 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Wang, WZ:
 Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China

Watt, K:
 James Cook Univ, Townsville, Qld 4811, Australia

Weinstock, MA:
 Brown Univ, Providence, RI 02912 USA

Weintraub, R:
 Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

 Royal Childrens Hosp, Melbourne, Vic, Australia

 Murdoch Childrens Res Inst, Melbourne, Vic, Australia

Weisskopf, MG:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Weissman, MM:
 Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

White, RA:
 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

Whiteford, H:
 Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia

Wilkinson, JD:
 Univ Miami, Miller Sch Med, Miami, FL 33136 USA

Williams, HC:
 Univ Nottingham, Nottingham NG7 2RD, England

Williams, SRM:
 Univ Western Sydney, Campbelltown, NSW, Australia

Wolfe, F:
 Arthrit Res, Wichita, KS USA

Woolf, AD:
 Royal Cornwall Hosp, Truro, England

Wulf, S:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA

Yeh, PH:
 London Sch Econ, London WC2A 2AE, England

Zaidi, AKM:
 Agwa Khan Univ, Karachi, Pakistan

Zheng, ZJ:
 Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200030, Peoples R China

Zonies, D:
 Landstuhl Reg Med Ctr, Landstuhl, Germany

Lopez, AD:
 Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

Murray, CJL:
 Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA
ISSN: 01406736
Editorial
Lancet Publishing Group, STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA, Reino Unido
Tipo de documento: Article
Volumen: 380 Número: 9859
Páginas: 2163-2196
WOS Id: 000312387000015
ID de PubMed: 23245607
imagen Green Accepted, Green Published, Green Submitted

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