Telangiectatic osteosarcoma
Por:
Colomina, J, Peiro, A, Trullols, L, Gracia, I
Publicada:
1 ene 2013
Resumen:
Purpose. To review records of 8 patients with telangiectatic osteosarcoma (TOS) and determine whether pathologic fractures correlate with recurrence and survival.
Methods. Records of 4 men and 4 women aged 17 to 44 (mean, 28) years treated for TOS were reviewed.
Results. Of the 8 patients, 4 developed a pathologic fracture and 4 did not. In each group, 2 patients underwent limb salvage surgery and 2 underwent amputation. All patients received neoadjuvant and adjuvant chemotherapy with a combination of at least 2 of the following drugs: doxorubicin, methotrexate, cisplatin, and vincristin. After a mean follow-up of 5.6 (range, 2-16) years, all 4 patients with a pathologic fracture and 2 of the 4 patients without a pathologic fracture were still alive and disease-free. For the remaining patients, one died after 31 months from progression of a lung metastasis, and the other was alive with the disease and had had 2 recurrences, a lung metastasis, and an infection with Klebsiella oxytoca that eventually led to an amputation.
Conclusion. The presence of a pathologic fracture in patients with TOS was not associated with worse outcome in terms of recurrence and survival.
Filiaciones:
Colomina, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Oncol Orthopaed Surg, E-08193 Barcelona, Spain
Peiro, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Oncol Orthopaed Surg, E-08193 Barcelona, Spain
Trullols, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Oncol Orthopaed Surg, E-08193 Barcelona, Spain
Gracia, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Oncol Orthopaed Surg, E-08193 Barcelona, Spain
gold
|