Overall Mortality and LDL Cholesterol Reduction in Secondary Prevention Trials of Cardiovascular Disease
Por:
Pedro-Botet, J, Lopez-Miranda, J, Badimon, L, Civeira, F, Guijarro, C, Millan, J, Mostaza, JM, Pinto, X, Valdivielso, P, Masana, L
Publicada:
1 ago 2020
Ahead of Print:
1 oct 2019
Resumen:
Pooled data from randomized clinical trials on lipid-lowering therapy have provided valuable information and clinical insights. Although cardiovascular disease is a common cause of death, mortality data have rarely been prominent in key lipid trials. The 4S, LIPID and HPS trials were the first to demonstrate a reduction in overall mortality. Lower- versus higher-intensity statin trials and non-statin lipid-lowering trials with ezetimibe and proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors proved that additional lipid lowering significantly reduces the occurrence of cardiovascular events. However, only the ODYSSEY OUTCOMES trial showed a reduction in all-cause mortality. The aim of the present narrative review was to contrast these results with those of other key lipid trials: those assessing statins compared with placebo, those evaluating intensive- versus moderate-intensity lipid-lowering therapy and, finally, those investigating non-statin lipid-lowering therapies.
Filiaciones:
Pedro-Botet, J:
Univ Autonoma Barcelona, Hosp del Mar, Dept Med, Unitat Lipids & Risc Vasc, Passeig Maritim 25-29, Barcelona 08003, Spain
Lopez-Miranda, J:
Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipid & Atherosclerosis Unit,Dept Internal Med,CI, Cordoba, Spain
Badimon, L:
Hosp Santa Creu & Sant Pau, Cardiovasc Program ICCC IR, CiberCV, IIB St Pau, Barcelona, Spain
Civeira, F:
Univ Zaragoza, CIBERCV, Unidad Lipidos, Hosp Univ Miguel Servet,IIS Aragon, Zaragoza, Spain
Guijarro, C:
Rey Juan Carlos Univ, Univ Hosp Alcorcon Fdn, Internal Med Unit, Madrid, Spain
Millan, J:
Univ Complutense, Hosp Univ Gen Gregorio Maranon, Dept Internal Med, Lipid Unit, Madrid, Spain
Mostaza, JM:
Hosp Carlos III, Internal Med Serv, Madrid, Spain
Pinto, X:
Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain
Valdivielso, P:
Univ Malaga, Virgen de La Victoria Univ Hosp, IBIMA,CIMES, Dept Med & Dermatol,Lipids & Atherosclerosis Lab, Malaga, Spain
Masana, L:
Univ Rovira & Virgili, Hosp Univ St Joan, Unitat Med Vasc & Metab, IISPV,CIBERDEM, Reus, Spain
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