Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
Por:
Sanchez-Castro, J, Marco-Betes, V, Gomez-Arbones, X, Arenillas, L, Valcarcel, D, Vallespi, T, Costa, D, Nomdedeu, B, Jimenez, MJ, Granada, I, Grau, J, Ardanaz, MT, de la Serna, J, Carbonell, F, Cervera, J, Sierra, A, Luno, E, Cervero, CJ, Falantes, J, Calasanz, MJ, Gonzalez-Porras, JR, Bailen, A, Amigo, ML, Sanz, G, Sole, F
Publicada:
1 jul 2013
Resumen:
The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.
This study assessed the impact on overall survival ( OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved.
The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. (C) 2013 Elsevier Ltd. All rights reserved.
Filiaciones:
Sanchez-Castro, J:
Hosp Arnau Vilanova, Lleida, Spain
Marco-Betes, V:
Hosp Arnau Vilanova, Lleida, Spain
Gomez-Arbones, X:
Hosp Arnau Vilanova, Lleida, Spain
Univ Lleida, Lleida, Spain
Arenillas, L:
Hosp del Mar, Barcelona, Spain
Valcarcel, D:
Hosp Valle De Hebron, Barcelona, Spain
Vallespi, T:
Hosp Valle De Hebron, Barcelona, Spain
Costa, D:
Hosp Clin Barcelona, Barcelona, Spain
Nomdedeu, B:
Hosp Clin Barcelona, Barcelona, Spain
Jimenez, MJ:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Granada, I:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Grau, J:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Ardanaz, MT:
Hosp Txagorritxu, Vitoria, Spain
de la Serna, J:
Hosp 12 Octubre, E-28041 Madrid, Spain
Carbonell, F:
Hosp Gen Univ, Valencia, Spain
Cervera, J:
Hosp Univ La Fe, Valencia, Spain
Sierra, A:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Luno, E:
Hosp Univ Cent Asturias, Oviedo, Spain
Cervero, CJ:
Hosp Virgen de la Luz, Cuenca, Spain
Falantes, J:
Hosp Virgen del Rocio, Seville, Spain
Calasanz, MJ:
Univ Navarra, E-31080 Pamplona, Spain
Gonzalez-Porras, JR:
Hosp Univ Salamanca, Salamanca, Spain
Bailen, A:
Hosp Univ Carlos Haya, Malaga, Spain
Amigo, ML:
Hosp Gen Univ Morales Meseguer, Murcia, Spain
Sanz, G:
Hosp Univ La Fe, Valencia, Spain
Sole, F:
Hosp del Mar, Barcelona, Spain
Autonomous Univ Barcelona, Fac Life Sci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
Green Submitted
|