Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial
Por:
Manchola-Gonzalez, JD, Bagur-Calafat, C, Girabent-Farres, M, Serra-Grima, JR, Perez, RA, Garnacho-Castano, MV, Badell, I, Ramirez-Velez, R
Publicada:
1 jul 2020
Ahead of Print:
1 nov 2019
Resumen:
Purpose The aim of this study was to evaluate the effects of a home-exercise programme on physical fitness indicators and physical functioning after completion of chemotherapy in children and adolescents diagnosed with acute lymphoblastic leukaemia (ALL). Methods Twenty-four survivors of ALL were assigned to usual care (control group, n = 12, 11.0 +/- 3.7 years) or to a home-exercise programme (intervention group, n = 12, 11.8 +/- 4.3 years). Peak oxygen uptake (VO(2)peak ml/kg/min), minute ventilation (VE L/min), output of carbon dioxide (VCO2 L/min), respiratory exchange ratio (RER), peak heart rate (beats/min), maximal load (W), VO2 at anaerobic threshold (VO2 at AT, ml/kg/min), pulse oxygen (PO2 ml/beat), heart rate at anaerobic threshold (beats/min), handgrip test (pounds), flexibility (cm), Timed Up & Go test TUG (s), and Timed Up and Down Stairs test (TUDS s) were measured at baseline and over 16 weeks of intervention. Results Adjusted mixed linear models revealed a significant group-time interaction + 6.7 (95% CI = 0.6-12.8 ml/kg/min; eta(2) partial = 0.046, P = 0.035) for VO(2)peak. Similarly, changes in mean values were observed after the home-exercise programme compared with baseline for VE (L/min) - 8.8 (3.0) (P = 0.035), VCO2 - 0.2 (0.08), (P = 0.041), maximal load (W) - 35.5 (12.8) (P = 0.024), TUDS (s) 0.8 (2.6) (P = 0.010), and TUG (s) 0.6 (0.1) (P = 0.001); however, the group-time interaction was not significant. Conclusion The home-exercise programme resulted in changes in measures of VO(2)peak, VE, VCO2, and functional capacity during daily life activities (TUDS and TUG test). This is an interesting and important study that surely adds to the current body of knowledge/literature on the safety of exercise interventions, especially in children with haematological cancer.
Filiaciones:
Manchola-Gonzalez, JD:
Univ Inernac Catalunya, Physiotherapy Dept, Barcelona, Spain
Bagur-Calafat, C:
Univ Inernac Catalunya, Physiotherapy Dept, Barcelona, Spain
Girabent-Farres, M:
Univ Inernac Catalunya, Physiotherapy Dept, Barcelona, Spain
Serra-Grima, JR:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Perez, RA:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Garnacho-Castano, MV:
TecnoCampus Pompeu Fabra Univ, Res Grp Phys Act Performance & Hlth GRI AFIRS, Sch Hlth Sci, Barcelona, Spain
Badell, I:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ramirez-Velez, R:
Navarrabiomed Univ Publ Navarra UPNA, CHN, Inst Invest Sanitaria Navarra IdiSNA, Navarra 31008, Spain
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