FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors
Por:
Montes, A, Perez-Pampin, E, Joven, B, Carreira, P, Fernandez-Nebro, A, Ordonez, MD, Navarro-Sarabia, F, Moreira, V, Vasilopoulos, Y, Sarafidou, T, Caliz, R, Ferrer, MA, Canete, JD, de la Serna, AR, Magallares, B, Narvaez, J, Gomez-Reino, JJ, Gonzalez, A
Publicada:
1 ene 2015
Resumen:
Objectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other Fc gamma R functional polymorphisms. Methods: Functional polymorphisms FCGR3A F158V, FCGR2B I223T and promoter VNTR in FCGRT were analyzed in up to 429 patients with RA. Response to TNFi was recorded during standard care at 3, 6 and 12 months of follow-up. Fixed effects meta-analysis of studies addressing FCGR3A F158V polymorphism, which is the most studied of these polymorphisms, was conducted with inverse variance weighting. Results: None of the functional polymorphisms were associated with change in DAS28. Meta-analysis of the seven studies (899 patients) with available data addressing association of FCGR3A F158V with response to TNFi in RA showed no association (OR: 1.11, 95% CI: 0.8-1.5; p = 0.5). Conclusion: None of the three functional polymorphisms in Fc gamma R genes showed association with response to TNFi in patients with RA. These negative results were obtained in spite of the larger size of this study relative to previous studies addressing the same polymorphisms. In addition, meta-analysis of FCGR3A F158V was also negative against the results provided by previous studies.
Filiaciones:
Montes, A:
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Lab Invest 10, Santiago De Compostela 15706, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Rheumatol Unit, Santiago De Compostela 15706, Spain
Perez-Pampin, E:
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Lab Invest 10, Santiago De Compostela 15706, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Rheumatol Unit, Santiago De Compostela 15706, Spain
Joven, B:
Hosp 12 Octubre, Reumatol Unit, E-28041 Madrid, Spain
Carreira, P:
Hosp 12 Octubre, Reumatol Unit, E-28041 Madrid, Spain
Fernandez-Nebro, A:
Univ Malaga, Hosp Reg Univ Malaga, UGC Reumatol, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain
Ordonez, MD:
Univ Malaga, Hosp Reg Univ Malaga, UGC Reumatol, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain
Navarro-Sarabia, F:
Hosp Univ Virgen Macarena, Rheumatol Unit, Seville 41009, Spain
Moreira, V:
Hosp Univ Virgen Macarena, Rheumatol Unit, Seville 41009, Spain
Vasilopoulos, Y:
Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece
Sarafidou, T:
Univ Thessaly, Dept Biochem & Biotechnol, Larisa 41221, Greece
Caliz, R:
Hosp Univ Virgen de las Nieves, Rheumatol Unit, Granada 18014, Spain
Ferrer, MA:
Hosp Univ Virgen de las Nieves, Rheumatol Unit, Granada 18014, Spain
Canete, JD:
Hosp Clin Barcelona, Rheumatol Unit, E-08036 Barcelona, Spain
IDIBAPS, Barcelona 08036, Spain
de la Serna, AR:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08026, Spain
Magallares, B:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08026, Spain
Narvaez, J:
Hosp Univ Bellvitge, Rheumatol Unit, Barcelona 08907, Spain
Gomez-Reino, JJ:
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Lab Invest 10, Santiago De Compostela 15706, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Rheumatol Unit, Santiago De Compostela 15706, Spain
Univ Santiago de Compostela, Dept Med, Santiago De Compostela, Spain
Gonzalez, A:
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Lab Invest 10, Santiago De Compostela 15706, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitaria, Rheumatol Unit, Santiago De Compostela 15706, Spain
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