Doubtful Role of IL28B Polymorphism in Occult Hepatitis B Infection
Por:
Bes, M, Vargas, V, Piron, M, Casamitjana, N, Esteban, JI, Campos-Varela, I, Puig, L, Sauleda, S
Publicada:
1 ene 2015
Resumen:
Aims: To investigate the influence of IL28B polymorphism in occult hepatitis B infection (OBI) and whether IL28B genetic variants are associated with hepatitis B virus (HBV)-specific T-cell responses. Patients and Methods: The rs12979860 IL28B genotype was determined in 34 OBI blood donors, 22 spontaneous HBV resolvers, 36 inactive HBV carriers and 25 seronegative donors. T-cell responses to HBV recombinant proteins were assessed by interferon-gamma enzyme-linked immunospot assay. Results: The frequency of the IL28B CC genotype among OBI patients was similar to that of inactive carriers [41 vs. 39%, respectively, p = 0.961; odds ratio (OR) = 1.10; 95% confidence interval (CI) = 0.42-2.86; p = 0.845]. The IL28B CC genotype was found more frequently in spontaneous resolvers, although the differences were not significant (45 vs. 39%, spontaneous resolvers and inactive carriers, respectively; p = 0.828; OR = 1.31; 95% CI = 0.45-3.83; p = 0.622). HBV-specific T-cell responses were detected in OBIs, and significantly stronger T-cell responses towards hepatitis B envelope antigen were observed in those with the IL28B CC genotype. In spontaneous resolvers and inactive carriers, IL28B CC did not correlate with the magnitude of T-cell responses. Conclusions: In OBI donors, IL28B CC correlates with the intensity of HBV-specific T-cell responses. In this study, IL28B CC is not statistically associated with OBI or with HBV clearance, but a larger number of cases is needed before completely ruling out its role in HBV infection. (C) 2015 S. Karger AG, Basel
Filiaciones:
Bes, M:
Banc Sang & Teixits, Serv Catala Salut, Transfus Safety Lab, ES-08035 Barcelona, Spain
UAB, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Bellaterra, Spain
Vargas, V:
Hosp Univ Vall dHebron, Inst Recerca, Dept Med & Liver Dis Lab, Liver Unit, Barcelona, Spain
UAB, Bellaterra, Spain
Piron, M:
Banc Sang & Teixits, Serv Catala Salut, Transfus Safety Lab, ES-08035 Barcelona, Spain
UAB, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Bellaterra, Spain
Casamitjana, N:
Banc Sang & Teixits, Serv Catala Salut, Transfus Safety Lab, ES-08035 Barcelona, Spain
Esteban, JI:
Hosp Univ Vall dHebron, Inst Recerca, Dept Med & Liver Dis Lab, Liver Unit, Barcelona, Spain
Campos-Varela, I:
Hosp Univ Vall dHebron, Inst Recerca, Dept Med & Liver Dis Lab, Liver Unit, Barcelona, Spain
UAB, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Bellaterra, Spain
Puig, L:
Banc Sang & Teixits, Serv Catala Salut, Transfus Safety Lab, ES-08035 Barcelona, Spain
UAB, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Bellaterra, Spain
Sauleda, S:
Banc Sang & Teixits, Serv Catala Salut, Transfus Safety Lab, ES-08035 Barcelona, Spain
UAB, Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Bellaterra, Spain
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