Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010
Por:
Crespo, I, Broner, S, Soldevila, N, Martinez, A, Godoy, P, Sala-Farre, MR, Company, M, Rius, C, Dominguez, A
Publicada:
1 ene 2015
Resumen:
In Catalonia, pertussis outbreaks must be reported to the Department of Health. This study analyzed pertussis outbreaks between 1997 and 2010 in general and according to the characteristics of the index cases. The outbreak rate, hospitalization rate and incidence of associated cases and their 95%CI were calculated. Index cases were classified in two groups according to age (< 15 years and 15 years) and the vaccine type received: whole cell vaccine (DTwP) or acellular vaccine (DTaP). During the study period, 230 outbreaks were reported. The outbreak rate was 2.43 x 10(-6) persons-year, and outbreaks ranged from 2 to 32 cases, with a median duration of 18 days. There were 771 associated cases, with an incidence rate of 0.8 x 10(-5) persons-year.
After classifying outbreaks according to the age of the index case, 126 outbreaks (1.3 x 10(-6) persons-year) had an index case aged < 15 y and 87 (0.87 x 10(-6) person-year) had an index case aged 15 y (RR = 1.44, 95%CI 1.10-1.90; P = 0.007). Between 2003 and 2010, after the introduction of the acellular vaccine, the index case was vaccinated with DTwP vaccine in 25 outbreaks (0.43 x 10(-6) persons-year) and with DTaP vaccine in 32 outbreaks (0.55 x 10(-6) person-year) (RR = 0.78, 95%CI 0.46-1.31; P = 0.35). Of cases, 37.2% were correctly vaccinated, suggesting waning immunity of pertussis vaccine protection and endogenous circulation of pertussis. A greater number of outbreaks had an index case aged < 15 y. No changes in the disease incidence, associated cases and hospitalization rate were observed after the introduction of DTaP.
Filiaciones:
Crespo, I:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Barcelona, Dept Publ Hlth, E-08007 Barcelona, Spain
Broner, S:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Soldevila, N:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Martinez, A:
Generalitat Catalonia, Publ Hlth Agcy Catalonia, Catalonia, Spain
Godoy, P:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Generalitat Catalonia, Publ Hlth Agcy Catalonia, Catalonia, Spain
Sala-Farre, MR:
Generalitat Catalonia, Publ Hlth Agcy Catalonia, Catalonia, Spain
Company, M:
Generalitat Catalonia, Publ Hlth Agcy Catalonia, Catalonia, Spain
Rius, C:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Publ Hlth Agcy Barcelona, Barcelona, Spain
Dominguez, A:
Carlos III Inst Hlth, CIBER Epidemiol & Salud Publ, Madrid, Spain
Univ Barcelona, Dept Publ Hlth, E-08007 Barcelona, Spain
Green Published, Bronze
|