Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program
Por:
Castells, X, Domingo, L, Corominas, JM, Tora-Rocamora, I, Quintana, MJ, Bare, M, Vidal, C, Natal, C, Sanchez, M, Saladie, F, Ferrer, J, Vernet, M, Servitja, S, Rodriguez-Arana, A, Roman, M, Espinas, JA, Sala, M
Publicada:
1 ene 2015
Resumen:
Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.
Filiaciones:
Castells, X:
Hosp del Mar Med Res Inst IMIM, Dept Epidemiol & Evaluat, Pg Maritim 25-29, Barcelona 08003, Catalonia, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Domingo, L:
Hosp del Mar Med Res Inst IMIM, Dept Epidemiol & Evaluat, Pg Maritim 25-29, Barcelona 08003, Catalonia, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Corominas, JM:
Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Catalonia, Spain
Tora-Rocamora, I:
Hosp del Mar Med Res Inst IMIM, Dept Epidemiol & Evaluat, Pg Maritim 25-29, Barcelona 08003, Catalonia, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Quintana, MJ:
Hosp Santa Creu & Sant Pau, Dept Epidemiol, Barcelona, Catalonia, Spain
Bare, M:
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Parc Tauli Univ Hosp, Sabadell, Catalonia, Spain
Vidal, C:
Catalan Inst Oncol, Canc Prevent & Monitoring Programme, Barcelona, Catalonia, Spain
Principal Asturias, Principal Asturias Breast Canc Screening Programm, Oviedo, Spain
Sanchez, M:
Govt Cantabria, Dept Hlth, Direct Gen Publ Hlth, Santander, Cantabria, Spain
Saladie, F:
Fdn League Res & Prevent Canc, Breast Canc Screening Programme Tarragona, Tarragona, Catalonia, Spain
Ferrer, J:
Hosp Santa Caterina, Dept Radiol, Girona, Catalonia, Spain
Vernet, M:
Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Catalonia, Spain
Servitja, S:
Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Catalonia, Spain
Rodriguez-Arana, A:
Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Catalonia, Spain
Roman, M:
Hosp del Mar Med Res Inst IMIM, Dept Epidemiol & Evaluat, Pg Maritim 25-29, Barcelona 08003, Catalonia, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Espinas, JA:
Catalan Canc Plan, Dept Hlth, Catalonia, Spain
Carlos III Hlth, Spanish Canc Res Network RTICC, Madrid, Spain
Sala, M:
Hosp del Mar Med Res Inst IMIM, Dept Epidemiol & Evaluat, Pg Maritim 25-29, Barcelona 08003, Catalonia, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
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