The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey
Por:
Bocchetta, M, Galluzzi, S, Kehoe, PG, Aguera, E, Bernabei, R, Bullock, R, Ceccaldi, M, Dartigues, JF, de Mendonca, A, Didic, M, Eriksdotter, M, Felician, O, Frolich, L, Gertz, HJ, Hallikainen, M, Hasselbalch, SG, Hausner, L, Heuser, I, Jessen, F, Jones, RW, Kurz, A, Lawlor, B, Lleo, A, Martinez-Lage, P, Mecocci, P, Mehrabian, S, Monsch, A, Nobili, F, Nordberg, A, Rikkert, MO, Orgogozo, JM, Pasquier, F, Peters, O, Salmon, E, Sanchez-Castellano, C, Santana, I, Sarazin, M, Traykov, L, Tsolaki, M, Visser, PJ, Wallin, AK, Wilcock, G, Wilkinson, D, Wolf, H, Yener, G, Zekry, D, Frisoni, GB
Publicada:
1 feb 2015
Resumen:
We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid position emission tomography [PET], cerebrospinal fluid [CSF] A beta 42) and neurodegeneration (medial temporal atrophy [MTA] on MR, fluorodeoxyglucose positron emission tomography [FDG-PET], CSF tau). The most frequently used biomarker is visually rated MTA (75% of the 37 responders reported using it "always/frequently") followed by CSF markers (22%), FDG-PET (16%), and amyloid-PET (3%). Only 45% of responders perceive MTA as contributing to diagnostic confidence, where the contribution was rated as "moderate". Seventy-nine percent of responders felt "very/extremely" comfortable delivering a diagnosis of MCI due to AD when both amyloid and neuronal injury biomarkers were abnormal (P < .02 versus any individual biomarker). Responders largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Filiaciones:
Bocchetta, M:
IRCCS Ist Ctr S Giovanni di Dio Fatebenefratelli, LENITEM, Brescia, Italy
Galluzzi, S:
IRCCS Ist Ctr S Giovanni di Dio Fatebenefratelli, LENITEM, Brescia, Italy
Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
Kehoe, PG:
Univ Bristol, Frenchay Hosp, Sch Clin Sci, Dementia Res Grp, Bristol, Avon, England
Aguera, E:
Hosp Univ Reina Sofia Cordoba, Serv Neurol, Cordoba, Spain
Bernabei, R:
Univ Cattolica Sacro Cuore, Dept Gerontol Geriatr & Psychiat Sci, Rome, Italy
Bullock, R:
Victoria Ctr, Swindon, Wilts, England
Ceccaldi, M:
Aix Marseille Univ, CHU Timone, Serv Neurol & Neuropsychol, Marseille, France
Dartigues, JF:
Bordeaux CMRR, Bordeaux, France
de Mendonca, A:
Inst Mol Med, Lab Neurosci, Lisbon, Portugal
Didic, M:
Aix Marseille Univ, CHU Timone, Serv Neurol & Neuropsychol, Marseille, France
Eriksdotter, M:
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Felician, O:
Aix Marseille Univ, CHU Timone, Serv Neurol & Neuropsychol, Marseille, France
Frolich, L:
Heidelberg Univ, Gesundheit Mannheim, Zentralinst Seel, Dept Geriatr Psychiat, Mannheim, Germany
Gertz, HJ:
Univ Hosp Leipzig, Dept Psychiat & Psychotherapy, Leipzig, Germany
Hallikainen, M:
Kuopio Univ Hosp, Univ Eastern Finland, SF-70210 Kuopio, Finland
Hasselbalch, SG:
Rigshosp, Memory Disorders Res Unit, DK-2100 Copenhagen, Denmark
Hausner, L:
Heidelberg Univ, Gesundheit Mannheim, Zentralinst Seel, Dept Geriatr Psychiat, Mannheim, Germany
Heuser, I:
Univ Klinikum Bonn, Klin & Poliklin Psychiat & Psychotherapie, Bonn, Germany
Jessen, F:
Univ Bonn, Dept Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Jones, RW:
Royal United Hosp, RICE Res Inst Care Older People, Bath BA1 3NG, Avon, England
Kurz, A:
Tech Univ Munich, Psychiat Klin, D-80290 Munich, Germany
Lawlor, B:
St James Hosp, Mercers Inst Res Ageing, Dublin 8, Ireland
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Serv, Memory Unit, Barcelona, Spain
Martinez-Lage, P:
Fdn CITA Alzheinzer Fundazioa, San Sebastian, Spain
Mecocci, P:
Univ Perugia, Sect Gerontol & Geriatr, I-06100 Perugia, Italy
Mehrabian, S:
Univ Hosp Alexandrovska, Dept Neurol, Sofia, Bulgaria
Monsch, A:
Univ Basel, Felix Platter Hosp, Univ Ctr Med Aging Basel, Memory Clin, Basel, Switzerland
Nobili, F:
Univ Genoa, Dept Neurosci DINOGMI, Neurol Clin, Genoa, Italy
Nordberg, A:
Victoria Ctr, Swindon, Wilts, England
Rikkert, MO:
Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, Dept Geriatr Med, NL-6525 ED Nijmegen, Netherlands
Orgogozo, JM:
Bordeaux CMRR, Bordeaux, France
Pasquier, F:
Univ Lille 2, CHU Lille, Lille, France
Peters, O:
Charite, Dept Psychiat, D-13353 Berlin, Germany
Salmon, E:
Univ Liege, Cyclotron Res Ctr, Liege, Belgium
Sanchez-Castellano, C:
Hosp Univ Ramon & Cajal, Serv Geriatria, Madrid, Spain
Santana, I:
Coimbra Univ Hosp, Dept Neurol, Coimbra, Portugal
Sarazin, M:
Univ Paris 05, Sorbonne Paris Cite, Ctr Hosp St Anne, INSERM UMR S894,Neurol Memoire & Langage, Paris, France
Traykov, L:
Univ Hosp Alexandrovska, Dept Neurol, Sofia, Bulgaria
Tsolaki, M:
Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece
Visser, PJ:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
Maastricht Univ, Alzheimer Ctr, NL-6200 MD Maastricht, Netherlands
Wallin, AK:
Lund Univ, Memory Clin Maloma, Clin Memory Res Unit, S-22100 Lund, Sweden
Wilcock, G:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England
Wilkinson, D:
Moorgreen Hosp, MARC, Southampton, Hants, England
Wolf, H:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Dept Psychiat Res, Zurich, Switzerland
Yener, G:
Dokuz Eylul Univ, Izmir, Turkey
Zekry, D:
Univ Hosp Geneva, Dept Internal Med & Geriatr, Geneva, Switzerland
Univ Geneva, Geneva, Switzerland
Frisoni, GB:
Univ Geneva, Geneva, Switzerland
Univ Hosp Geneva, Memory Clin, Geneva, Switzerland
Green Accepted
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