Association Between Nailfold Capillaroscopy Findings and Pulmonary Function Tests in Patients with Systemic Sclerosis
Por:
Castellvii, I, Simeoon-Aznar, CP, Sarmiento, M, Fortuna, A, Mayos, M, Geli, C, Diaz-Tornee, C, Moya, P, de Llobet, JM, Casademont, J
Publicada:
1 feb 2015
Resumen:
Objective. To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc).
Methods. We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120x were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/ DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH).
Results. Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 +/- 19.42 vs 101.13 +/- 16.06, p < 0.01) and DLCO% (71.43 +/- 21.19 vs 85.9 +/- 19.81, p < 0.01) compared to those without.
Conclusion. Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.
Filiaciones:
Castellvii, I:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08025, Spain
Fortuna, A:
Hosp Santa Creu & Sant Pau, Dept Pneumol, Barcelona 08025, Spain.
Mayos, M:
Hosp Santa Creu & Sant Pau, Dept Pneumol, Barcelona 08025, Spain.
Geli, C:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08025, Spain
Diaz-Tornee, C:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08025, Spain
Moya, P:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08025, Spain
de Llobet, JM:
Hosp Santa Creu & Sant Pau, Rheumatol Unit, Barcelona 08025, Spain
Casademont, J:
Universitat Autònoma de Barcelona, Department of Internal Medicine, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain
Hosp Univ Valle Hebron, Dept Internal Med, Barcelona, Spain.
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