Autoantibodies against TIF-1-gamma and CADM-140 in Spanish patients with clinically amyopathic dermatomyositis (CADM): clinical significance and diagnostic utility
Por:
Cuesta-Mateos, C, Colom-Fernandez, B, Portero-Sainz, I, Tejedor, R, Garcia-Garcia, C, Concha-Garzon, MJ, De las Heras-Alonso, ME, Martinez, MA, Juarez, C, Munoz-Calleja, C
Publicada:
1 mar 2015
Resumen:
BackgroundPatients with clinically amyopathic dermatomyositis (CADM) appear to be at risk for developing cancer and interstitial lung diseases, but population data to confirm this hypothesis are limited. Moreover, CADM presents cutaneous and histological findings that may overlap with subacute cutaneous lupus erythematosus (SCLE).
ObjectivesTo determine the association between myositis-specific autoantibodies, myositis-associated autoantibodies and CADM in Spanish patients. In addition, to study the usefulness of these autoantibodies in the differential diagnosis between CADM and SCLE.
MethodsSerum samples were tested for myositis-specific autoantibodies and myositis-associated autoantibodies through immunoprecipitation and other standardized methods.
ResultsAnti-CADM-p140 and anti-p155 antibodies were the only myositis-specific autoantibodies found and were associated with interstitial lung diseases and cancer respectively. No myositis-associated autoantibodies were found in CADM. Moreover, clinical subsets and proportions seemed to differ from Asian cohorts, where anti-CADM-p140 is considered a CADM hallmark antibody and a risk factor for the development of interstitial lung disease. Interestingly, anti-SSA was highly associated with SCLE, whereas no myositis-specific autoantibodies were found in this entity.
Limitations of the studyAssociation between CADM and myositis-specific autoantibodies and differences between CADM and SCLE were tested on a relatively small cohort of patients.
ConclusionThere is an association between cancer-associated myositis and interstitial lung diseases and their hallmark autoantibodies in our cohort. In addition, the combined determination of myositis-specific autoantibodies and SSA autoantibodies may help to accurately discriminate SCLE from CADM.
Filiaciones:
Cuesta-Mateos, C:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Inmunol, Granada, Spain
IMMED SL, Immunol & Med Prod, Madrid, Spain
Colom-Fernandez, B:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Inmunol, Granada, Spain
Portero-Sainz, I:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Inmunol, Granada, Spain
Tejedor, R:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Inmunol, Granada, Spain
Garcia-Garcia, C:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Dermatol, Madrid, Spain
Concha-Garzon, MJ:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Dermatol, Madrid, Spain
De las Heras-Alonso, ME:
Hosp Univ Ramon & Cajal, Dept Dermatol, Madrid, Spain
Martinez, MA:
Hosp Santa Creu & Sant Pau, Dept Inmunol, Barcelona, Spain
Juarez, C:
Hosp Santa Creu & Sant Pau, Dept Inmunol, Barcelona, Spain
Munoz-Calleja, C:
Inst Invest Sanitaria Hosp Univ Princesa, Dept Inmunol, Granada, Spain
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