Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper
Por:
Girolomoni, G, Griffiths, CEM, Krueger, J, Nestle, FO, Nicolas, JF, Prinz, JC, Puig, L, Stahle, M, van de Kerkhof, PCM, Allez, M, Emery, P, Paul, C
Publicada:
1 abr 2015
Resumen:
Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway ("early intervention") with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.
Filiaciones:
Girolomoni, G:
Univ Verona, Sect Dermatol & Venereol, Dept Med, I-37100 Verona, Italy
Griffiths, CEM:
Univ Manchester, Manchester Acad Hlth Sci Ctr, Salford Royal Hosp, Dermatol Ctr, Manchester, Lancs, England
Krueger, J:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Nestle, FO:
Guys Hosp, Kings Coll London, St Johns Inst Dermatol, Sch Med,Div Genet & Mol Med, London SE1 9RT, England
Nicolas, JF:
Univ Lyon, UFR Lyon Sud, INSERM, Dept Allergol & Clin Immunol,U851,IFR 128, Lyon, France
Prinz, JC:
Univ Munich, Dept Dermatol, D-80539 Munich, Germany
Puig, L:
Univ Autonoma Barcelona, Dept Dermatol, Hosp Santa Creu & St Pau, E-08193 Barcelona, Spain
Stahle, M:
Karolinska Inst, Dept Med, Unit Dermatol, Stockholm, Sweden
van de Kerkhof, PCM:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, NL-6525 ED Nijmegen, Netherlands
Allez, M:
Univ Denis Diderot Paris 7, APHP, St Louis Hosp, Dept Gastroenterol, Paris, France
Emery, P:
Univ Leeds, Chapel Allerton Hosp, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
Leeds Teaching Hosp NHS Trust, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England
Paul, C:
Univ Toulouse 3, F-31059 Toulouse, France
Hop Larrey, Dept Dermatol, F-31059 Toulouse, France
Green Published
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