Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers
Por:
Blanco, I, Kuchenbaecker, K, Cuadras, D, Wang, XS, Barrowdale, D, Garibay, GR, Librado, P, Sanchez-Gracia, A, Rozas, J, Bonifaci, N, McGuffog, L, Pankratz, VS, Islam, A, Mateo, F, Berenguer, A, Petit, A, Catala, I, Brunet, J, Feliubadalo, L, Tornero, E, Benitez, J, Osorio, A, Cajal, TRY, Nevanlinna, H, Aittomaki, K, Arun, BK, Toland, AE, Karlan, BY, Walsh, C, Lester, J, Greene, MH, Mai, PL, Nussbaum, RL, Andrulis, IL, Domchek, SM, Nathanson, KL, Rebbeck, TR, Barkardottir, RB, Jakubowska, A, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Claes, K, Van Maerken, T, Diez, O, Hansen, TV, Jonson, L, Gerdes, AM, Ejlertsen, B, de la Hoya, M, Caldees, T, Dunning, AM, Oliver, C, Fineberg, E, Cook, M, Peock, S, McCann, E, Murray, A, Jacobs, C, Pichert, G, Lalloo, F, Chu, C, Dorkins, H, Paterson, J, Ong, KR, Teixeira, MR, Teixeira, Hogervorst, FBL, van der Hout, AH, Seynaeve, C, van der Luijt, RB, Ligtenberg, MJL, Devilee, P, Wijnen, JT, Rookus, MA, Meijers-Heijboer, HEJ, Blok, MJ, van den Ouweland, AMW, Aalfs, CM, Rodriguez, GC, Phillips, KAA, Piedmonte, M, Nerenstone, SR, Bae-Jump, VL, O'Malley, DM, Ratner, ES, Schmutzler, RK, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, HJ, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Bojesen, A, Pedersen, IS, Sunde, L, Jensen, UB, Thomassen, M, Kruse, TA, Foretova, L, Peterlongo, P, Bernard, L, Peissel, B, Scuvera, G, Manoukian, S, Radice, P, Ottini, L, Montagna, M, Agata, S, Maugard, C, Simard, J, Soucy, P, Berger, A, Fink-Retter, A, Singer, CF, Rappaport, C, Geschwantler-Kaulich, D, Tea, MK, Pfeiler, G, John, EM, Miron, A, Neuhausen, SL, Terry, MB, Chung, WK, Daly, MB, Goldgar, DE, Janavicius, R, Dorfling, CM, van Rensburg, EJ, Fostira, F, Konstantopoulou, I, Garber, J, Godwin, AK, Olah, E, Narod, SA, Rennert, G, Paluch, SS, Laitman, Y, Friedman, E, Liljegren, A, Rantala, J, Stenmark-Askmalm, M, Loman, N, Imyanitov, EN, Hamann, U, Spurdle, AB, Healey, S, Weitzel, JN, Herzog, J, Margileth, D, Gorrini, C, Esteller, M, Gomez, A, Sayols, S, Vidal, E, Heyn, H, Stoppa-Lyonnet,, Leone, M, Barjhoux, L, Fassy-Colcombet, M, de Pauw, A, Lasset, C, Ferrer, SF, Castera, L, Berthet, P, Cornelis, F, Bignon, YJ, Damiola, F, Mazoyer, S, Sinilnikova, OM, Maxwell, CA, Vijai, J, Robson, M, Kauff, N, Corines, MJ, Villano, D, Cunningham, J, Lee, A, Lindor, N, Lazaro, C, Easton, DF, Offit, K, Chenevix-Trench, G, Couch, FJ, Antoniou, AC, Pujana, MA
Publicada:
1 abr 2015
Resumen:
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04 - 1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03 - 1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted p(interaction) values > 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients' survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers.
Filiaciones:
Blanco, I:
Bellvitge Inst Biomed Res IDIBELL, Hereditary Canc Program, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Kuchenbaecker, K:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Cuadras, D:
Bellvitge Inst Biomed Res IDIBELL, Stat Unit, Lhospitalet Del Llobrega, Catalonia, Spain
Wang, XS:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Barrowdale, D:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Garibay, GR:
Bellvitge Inst Biomed Res IDIBELL, Breast Canc & Syst Biol Unit, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Librado, P:
Univ Barcelona, Dept Genet & Biodivers Res Inst IRBio, Barcelona, Catalonia, Spain
Sanchez-Gracia, A:
Univ Barcelona, Dept Genet & Biodivers Res Inst IRBio, Barcelona, Catalonia, Spain
Rozas, J:
Univ Barcelona, Dept Genet & Biodivers Res Inst IRBio, Barcelona, Catalonia, Spain
Bonifaci, N:
Bellvitge Inst Biomed Res IDIBELL, Breast Canc & Syst Biol Unit, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
McGuffog, L:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Pankratz, VS:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Islam, A:
Univ Dhaka, Dept Genet Engn & Biotechnol, Dhaka 1000, Bangladesh
Mateo, F:
Bellvitge Inst Biomed Res IDIBELL, Breast Canc & Syst Biol Unit, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Berenguer, A:
Bellvitge Inst Biomed Res IDIBELL, Stat Unit, Lhospitalet Del Llobrega, Catalonia, Spain
Petit, A:
Bellvitge Inst Biomed Res IDIBELL, Univ Hosp Bellvitge, Dept Pathol, Lhospitalet Del Llobrega, Catalonia, Spain
Catala, I:
Bellvitge Inst Biomed Res IDIBELL, Univ Hosp Bellvitge, Dept Pathol, Lhospitalet Del Llobrega, Catalonia, Spain
Brunet, J:
Hosp Josep Trueta, Girona Biomed Res Inst IDIBGI, Hereditary Canc Program, Catalan Inst Oncol ICO, Girona, Catalonia, Spain
Feliubadalo, L:
Bellvitge Inst Biomed Res IDIBELL, Hereditary Canc Program, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Tornero, E:
Bellvitge Inst Biomed Res IDIBELL, Hereditary Canc Program, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Benitez, J:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis, Madrid, Spain
Osorio, A:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis, Madrid, Spain
Cajal, TRY:
Hosp Santa Creu & Sant Pau, Oncol Serv, Barcelona, Catalonia, Spain
Nevanlinna, H:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Cent Hosp, Helsinki, Finland
Aittomaki, K:
Univ Helsinki, Cent Hosp, Dept Clin Genet, Helsinki, Finland
Arun, BK:
Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
Toland, AE:
Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med & Mol Virol Immunol & Med Genet, Div Human Canc Genet, Columbus, OH 43210 USA
Karlan, BY:
Cedars Sinai Med Ctr, Ctr Comprehens Canc, Womens Canc Program Samuel Oschin, Los Angeles, CA 90048 USA
Walsh, C:
Cedars Sinai Med Ctr, Ctr Comprehens Canc, Womens Canc Program Samuel Oschin, Los Angeles, CA 90048 USA
Lester, J:
Cedars Sinai Med Ctr, Ctr Comprehens Canc, Womens Canc Program Samuel Oschin, Los Angeles, CA 90048 USA
Greene, MH:
Natl Canc Inst, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA
Mai, PL:
Natl Canc Inst, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA
Nussbaum, RL:
Univ Calif San Francisco, Dept Med & Genet, San Francisco, CA 94143 USA
Andrulis, IL:
Univ Toronto, Samuel Lunenfeld Res Inst, Mt Sinai Hosp, Toronto, ON, Canada
Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Domchek, SM:
Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
Nathanson, KL:
Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
Rebbeck, TR:
Univ Penn Perelman, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn Perelman, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Barkardottir, RB:
Univ Iceland, Dept Pathol, Landspitali Univ Hosp, Reykjavik, Iceland
Univ Iceland, Fac Med, BMC, Reykjavik, Iceland
Jakubowska, A:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Durda, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jaworska-Bieniek, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Claes, K:
Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium
Van Maerken, T:
Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium
Diez, O:
Vall Hebron Res Inst VHIR, Vall Hebron Inst Oncol, Oncogenet Grp, Barcelona, Catalonia, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Catalonia, Spain
Hansen, TV:
Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Jonson, L:
Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Gerdes, AM:
Copenhagen Univ Hosp, Rigshosp, Dept Clin Genet, Copenhagen, Denmark
Ejlertsen, B:
Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark
de la Hoya, M:
San Carlos Res Inst IdISSC, Mol Oncol Lab, Hosp Clin San Carlos, Madrid, Spain
Caldees, T:
San Carlos Res Inst IdISSC, Mol Oncol Lab, Hosp Clin San Carlos, Madrid, Spain
Dunning, AM:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Oliver, C:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Fineberg, E:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Cook, M:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Peock, S:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
McCann, E:
Glan Clwyd Gen Hosp, All Wales Med Genet Serv, Rhyl, Wales
Murray, A:
Singleton Hosp, All Wales Med Genet Serv, Swansea SA2 8QA, W Glam, Wales
Jacobs, C:
Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Clin Genet, London, England
Pichert, G:
Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Clin Genet, London, England
Lalloo, F:
Cent Manchester Univ Hosp Natl Hlth Serv NHS Fdn, Manchester Acad Hlth Sci Ctr, Genet Med, Manchester, Lancs, England
Chu, C:
Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Dorkins, H:
Kennedy Galton Ctr, North West Thames Reg Genet Serv, Harrow, Middx, England
Paterson, J:
Addenbrookes Hosp, Dept Clin Genet, East Anglian Reg Genet Serv, Cambridge, England
Ong, KR:
Birmingham Womens Hosp Healthcare Natl Hlth Serv, West Midlands Reg Genet Serv, Birmingham, W Midlands, England
Teixeira, MR:
Univ Porto, Dept Genet, Portuguese Oncol Inst, P-4100 Porto, Portugal
Univ Porto, Biomed Sci Inst ICBAS, P-4100 Porto, Portugal
Teixeira:
Univ Porto, Dept Genet, Portuguese Oncol Inst, P-4100 Porto, Portugal
Univ Porto, Biomed Sci Inst ICBAS, P-4100 Porto, Portugal
Netherlands Canc Inst NKI, Hereditary Breast & Ovarian Canc Res Grp Netherla, Amsterdam, Netherlands
Hogervorst, FBL:
Netherlands Canc Inst NKI, Family Canc Clin, Amsterdam, Netherlands
van der Hout, AH:
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
Seynaeve, C:
Erasmus Univ, Med Ctr, Dept Med Oncol, Family Canc Clin, Rotterdam, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Ligtenberg, MJL:
Radboud Univ Nijmegen, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands
Radboud Univ Nijmegen, Dept Pathol, NL-6525 ED Nijmegen, Netherlands
Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands
Devilee, P:
Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands
Wijnen, JT:
Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands
Rookus, MA:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Meijers-Heijboer, HEJ:
Vrije Univ VJ Univ Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Blok, MJ:
Maastricht Univ, Med Ctr, Dept Clin Genet, NL-6200 MD Maastricht, Netherlands
van den Ouweland, AMW:
Erasmus Univ, Med Ctr, Dept Clin Genet, Rotterdam, Netherlands
Aalfs, CM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
Rodriguez, GC:
Univ Chicago, NorthShore Univ HealthSyst, Div Gynecol Oncol, Chicago, IL 60637 USA
Phillips, KAA:
Peter MacCallum Canc Ctr, Div Canc Med, East Melbourne, Vic, Australia
Piedmonte, M:
Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA
Nerenstone, SR:
Hartford Hosp, Helen & Harry Gray Canc Ctr, Cent Connecticut Canc Consortium, Hartford, CT USA
Bae-Jump, VL:
Univ N Carolina, Dept Obstet & Gynecol, Div Gynecol Oncol, Chapel Hill, NC USA
O'Malley, DM:
Ohio State Univ, Columbus Canc Council, Div Gynecol Oncol, Hilliard, OH USA
Ratner, ES:
Yale Univ, Sch Med, Div Gynecol Oncol, New Haven, CT USA
Schmutzler, RK:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany
Wappenschmidt, B:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany
Engel, C:
Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04109 Leipzig, Germany
Meindl, A:
Tech Univ Munich, Dept Gynecol & Obstet, Klinikum Rechts Isar, Div Tumor Genet, D-80290 Munich, Germany
Ditsch, N:
Univ Munich, Dept Gynecol & Obstet, Munich, Germany
Arnold, N:
Univ Kiel, Univ Med Ctr Schleswig Holstein, Dept Gynecol & Obstet, Kiel, Germany
Plendl, HJ:
Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Human Genet, Kiel, Germany
Niederacher, D:
Univ Dusseldorf, Univ Hosp Dseeldorf, Dept Gynecol & Obstet, Dusseldorf, Germany
Sutter, C:
Univ Heidelberg Hosp, Inst Human Genet, Dept Human Genet, Heidelberg, Germany
Wang-Gohrke, S:
Univ Hosp Ulm, Dept Gynecol & Obstet, Ulm, Germany
Steinemann, D:
Hannover Med Sch, Inst Cell & Mol Pathol, Hannover, Germany
Preisler-Adams, S:
Univ Munster, Inst Human Genet, D-48149 Munster, Germany
Kast, K:
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Gynecol & Obstet, D-01062 Dresden, Germany
Varon-Mateeva, R:
Charite, Inst Human Genet, Campus Virchov Klinikum, Berlin, Germany
Gehrig, A:
Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, D-97070 Wurzburg, Germany
Bojesen, A:
Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Pedersen, IS:
Aalborg Univ Hosp, Dept Biochem, Sect Mol Diagnost, Aalborg, Denmark
Sunde, L:
Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Thomassen, M:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Kruse, TA:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Foretova, L:
Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Peterlongo, P:
Fdn Italiana Ric Cancro, Fdn Ist Oncol Mol IFOM, Milan, Italy
Bernard, L:
Cogentech Canc Genet Test Lab, Ist Europeo Oncol, Dept Expt Oncol, Milan, Italy
Peissel, B:
Fdn Ist Nazl Tumori INT, IRCCS, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Scuvera, G:
Fdn Ist Nazl Tumori INT, IRCCS, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Manoukian, S:
Fdn Ist Nazl Tumori INT, IRCCS, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Radice, P:
Fdn Ist Nazl Tumori INT, IRCCS, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predict Med, Milan, Italy
Ottini, L:
Univ Roma La Sapienza, Dept Mol Med, Rome, Italy
Montagna, M:
IRCCS, Immunol & Mol Oncol Unit, Ist Oncol Veneto, Padua, Italy
Agata, S:
IRCCS, Immunol & Mol Oncol Unit, Ist Oncol Veneto, Padua, Italy
Maugard, C:
Hop Univ Strasbourg, CHRU, Nouvel Hop Civil, Lab Diagnost Genet & Serv Onco Hematol, Strasbourg, France
Simard, J:
Ctr Hosp Univ Quebec, Res Ctr, Canc Genom Lab, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
Soucy, P:
Ctr Hosp Univ Quebec, Res Ctr, Canc Genom Lab, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
Berger, A:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Fink-Retter, A:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Singer, CF:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Rappaport, C:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Geschwantler-Kaulich, D:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Tea, MK:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Pfeiler, G:
Med Univ Vienna, Dept Gynecol & Obstet, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
John, EM:
Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA
Miron, A:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
Neuhausen, SL:
Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
Terry, MB:
Columbia Univ, Dept Epidemiol, New York, NY USA
Chung, WK:
Columbia Univ, Med Ctr, Dept Pediat & Med, New York, NY USA
Daly, MB:
Fox Chase Canc Ctr, Dept Clin Genet, Philadelphia, PA 19111 USA
Goldgar, DE:
Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USA
Janavicius, R:
Vilnius Univ, Dept Mol & Regenerat Med, Hematol Oncol & Transfus Med Ctr, Hosp Santariskiu Clin,State Res Ctr Inst Innovat, Vilnius, Lithuania
Dorfling, CM:
Univ Pretoria, Dept Genet, Canc Genet Lab, Arcadia, South Africa
van Rensburg, EJ:
Univ Pretoria, Dept Genet, Canc Genet Lab, Arcadia, South Africa
Fostira, F:
Natl Ctr Sci Res Demokritos, Inst Radioisotopes & Radiodiagnost Prod, Mol Diagnost Lab, Athens, Greece
Konstantopoulou, I:
Natl Ctr Sci Res Demokritos, Inst Radioisotopes & Radiodiagnost Prod, Mol Diagnost Lab, Athens, Greece
Garber, J:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Canc Genet & Prevent, Boston, MA USA
Godwin, AK:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Olah, E:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Narod, SA:
Univ Toronto, Womens Coll Res Inst, Toronto, ON, Canada
Rennert, G:
Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Carmel Hosp, Dept Commun Med & Epidemiol, Haifa, Israel
B Rappaport Fac Med, Haifa, Israel
Paluch, SS:
Chaim Sheba Med Ctr, Inst Oncol, Ramat Gan, Israel
Laitman, Y:
Chaim Sheba Med Ctr, Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, Ramat Gan, Israel
Friedman, E:
Chaim Sheba Med Ctr, Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, Ramat Gan, Israel
Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel
Liljegren, A:
Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden
Rantala, J:
Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden
Stenmark-Askmalm, M:
Linkoping Univ, Dept Clin & Expt Med, Div Clin Genet, Linkoping, Sweden
Loman, N:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Imyanitov, EN:
NN Petrov Inst Oncol, St Petersburg, Russia
Hamann, U:
German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany
Spurdle, AB:
Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld 4006, Australia
Healey, S:
Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld 4006, Australia
Weitzel, JN:
City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA
Herzog, J:
City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA
Margileth, D:
Care City Hope Clin Canc Genet Commun Res Network, St Joseph Hosp Orange, Duarte, CA USA
Gorrini, C:
Univ Hlth Network, Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON, Canada
Esteller, M:
IDIBELL, Canc Epigenet & Biol Program PEBC, Lhospitalet Del Llobrega, Catalonia, Spain
Univ Barcelona, Sch Med, Dept Physiol Sci 2, Lhospitalet Del Llobrega, Catalonia, Spain
Catalan Inst Res & Adv Studies ICREA, Barcelona, Catalonia, Spain
Gomez, A:
IDIBELL, Canc Epigenet & Biol Program PEBC, Lhospitalet Del Llobrega, Catalonia, Spain
Sayols, S:
IDIBELL, Canc Epigenet & Biol Program PEBC, Lhospitalet Del Llobrega, Catalonia, Spain
Vidal, E:
IDIBELL, Canc Epigenet & Biol Program PEBC, Lhospitalet Del Llobrega, Catalonia, Spain
Heyn, H:
IDIBELL, Canc Epigenet & Biol Program PEBC, Lhospitalet Del Llobrega, Catalonia, Spain
Stoppa-Lyonnet,:
Inst Curie, Dept Tumor Biol, Paris, France
Inst Curie, INSERM, U830, Paris, France
Univ Paris 05, Sorbonne Paris Cite, Paris, France
Leone, M:
Hosp Civils Lyon, Ctr Leon Berard, Unit Mixte Genet Constitut Canc Frequents, Lyon, France
Barjhoux, L:
Univ Lyon 1, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, F-69365 Lyon, France
Fassy-Colcombet, M:
Inst Curie, Dept Tumor Biol, Paris, France
de Pauw, A:
Inst Curie, Dept Tumor Biol, Paris, France
Lasset, C:
Univ Lyon 1, CNRS, UMR5558, F-69365 Lyon, France
Ctr Leon Berard, Unit Prevent & Epidemiol Genet, F-69373 Lyon, France
Ferrer, SF:
Hop Hotel Dieu, Ctr Hosp, Lab Genet Chromosom, Chambery, France
Castera, L:
Inst Curie, Dept Tumor Biol, Paris, France
Berthet, P:
Ctr Francois Baclesse, F-14021 Caen, France
Cornelis, F:
Avicenne Hosp, AP HP, Genet Unit, Paris, France
Sud Francilien Hosp, Evry, France
Univ Hosp, Clermont Ferrand, France
Bignon, YJ:
Univ Clermont Ferrand 2, Ctr Jean Perrin, Dept Oncogenet, Clermont Ferrand, France
Damiola, F:
Univ Lyon 1, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, F-69365 Lyon, France
Mazoyer, S:
Univ Lyon 1, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, F-69365 Lyon, France
Sinilnikova, OM:
Hosp Civils Lyon, Ctr Leon Berard, Unit Mixte Genet Constitut Canc Frequents, Lyon, France
Univ Lyon 1, CNRS, INSERM, Ctr Rech Cancerol Lyon,U1052,UMR5286, F-69365 Lyon, France
Maxwell, CA:
Univ British Columbia, Dept Pediat, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada
Vijai, J:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Robson, M:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Kauff, N:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Corines, MJ:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Villano, D:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Cunningham, J:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Lee, A:
Mayo Clin, Dept Oncol, Rochester, MN USA
Lindor, N:
Mayo Clin Scottsdale, Ctr Individualized Med, Scottsdale, AZ USA
Lazaro, C:
Bellvitge Inst Biomed Res IDIBELL, Hereditary Canc Program, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Easton, DF:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Offit, K:
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, New York, NY 10021 USA
Chenevix-Trench, G:
Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld 4006, Australia
Couch, FJ:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Antoniou, AC:
Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Epidemiol Study Familial Breast Canc,Ctr Canc Gen, Cambridge, England
Pujana, MA:
Bellvitge Inst Biomed Res IDIBELL, Breast Canc & Syst Biol Unit, Catalan Inst Oncol ICO, Lhospitalet Del Llobrega, Catalonia, Spain
Green Published, gold
|