Molecular networks in Network Medicine: Development and applications
Por:
Silverman, EK, Schmidt, HHHW, Anastasiadou, E, Altucci, L, Angelini, M, Badimon, L, Balligand, JL, Benincasa, G, Capasso, G, Conte, F, Di Costanzo, A, Farina, L, Fiscon, G, Gatto, L, Gentili, M, Loscalzo, J, Marchese, C, Napoli, C, Paci, P, Petti, M, Quackenbush, J, Tieri, P, Viggiano, D, Vilahur, G, Glass, K, Baumbach, J
Publicada:
1 nov 2020
Ahead of Print:
1 abr 2020
Resumen:
Network Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein-protein interaction networks, correlation-based networks, gene regulatory networks, and Bayesian networks. Network Medicine applies these integrated approaches to Omics Big Data (including genetics, epigenetics, transcriptomics, metabolomics, and proteomics) using computational biology tools and, thereby, has the potential to provide improvements in the diagnosis, prognosis, and treatment of complex diseases. We discuss briefly the types of molecular data that are used in molecular network analyses, survey the analytical methods for inferring molecular networks, and review efforts to validate and visualize molecular networks. Successful applications of molecular network analysis have been reported in pulmonary arterial hypertension, coronary heart disease, diabetes mellitus, chronic lung diseases, and drug development. Important knowledge gaps in Network Medicine include incompleteness of the molecular interactome, challenges in identifying key genes within genetic association regions, and limited applications to human diseases.
This article is categorized under:
Models of Systems Properties and Processes > Mechanistic Models
Translational, Genomic, and Systems Medicine > Translational Medicine
Analytical and Computational Methods > Analytical Methods
Analytical and Computational Methods > Computational Methods
Filiaciones:
Silverman, EK:
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Boston, MA 02115 USA
Schmidt, HHHW:
Maastricht Univ, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, Dept Pharmacol & Personalized Med, Maastricht, Netherlands
Anastasiadou, E:
Sapienza Univ Rome, Dept Expt Med, Rome, Italy
Altucci, L:
Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy
Angelini, M:
Sapienza Univ Rome, Dept Comp Control & Management Engn, Rome, Italy
Badimon, L:
Autonomous Univ Barcelona, Cardiovasc Program ICCC, IR Hosp Santa Creu & St Pau, CiberCV,IIB St Pau, Barcelona, Spain
Balligand, JL:
UCLouvain, Inst Clin & Expt Res IREC, Pole Pharmacol & Therapeut FATH, Brussels, Belgium
Benincasa, G:
Univ Campania Luigi Vanvitelli, Dept Adv Clin & Surg Sci, Naples, Italy
Capasso, G:
Univ Campania L Vanvitelli, Dept Translat Med Sci, Naples, Italy
BIOGEM, Ariano Irpino, Italy
Conte, F:
CNR, Inst Syst Anal & Comp Sci Antonio Ruberti, Rome, Italy
Di Costanzo, A:
Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy
Farina, L:
Sapienza Univ Rome, Dept Comp Control & Management Engn, Rome, Italy
Fiscon, G:
CNR, Inst Syst Anal & Comp Sci Antonio Ruberti, Rome, Italy
Gatto, L:
Duve Inst, Brussels, Belgium
UCLouvain, Inst Expt & Clin Res IREC, Brussels, Belgium
Gentili, M:
Sapienza Univ Rome, Dept Comp Control & Management Engn, Rome, Italy
Loscalzo, J:
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Div Cardiovasc Med, 75 Francis St, Boston, MA 02115 USA
Marchese, C:
Sapienza Univ Rome, Dept Expt Med, Rome, Italy
Napoli, C:
Univ Campania Luigi Vanvitelli, Dept Adv Clin & Surg Sci, Naples, Italy
Paci, P:
Sapienza Univ Rome, Dept Comp Control & Management Engn, Rome, Italy
Petti, M:
Sapienza Univ Rome, Dept Comp Control & Management Engn, Rome, Italy
Quackenbush, J:
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Boston, MA 02115 USA
Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
Tieri, P:
CNR Natl Res Council Italy, IAC, Rome, Italy
Viggiano, D:
BIOGEM, Ariano Irpino, Italy
Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy
Vilahur, G:
Autonomous Univ Barcelona, Cardiovasc Program ICCC, IR Hosp Santa Creu & St Pau, CiberCV,IIB St Pau, Barcelona, Spain
Glass, K:
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Boston, MA 02115 USA
Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
Baumbach, J:
Tech Univ Munich, TUM Sch Life Sci Weihenstephan, Dept Expt Bioinformat, Maximus von Imhof Forum 3, Freising Weihenstephan, Germany
Univ Southern Denmark, Inst Math & Comp Sci, Odense, Denmark
Green Published
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