From proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implications
Por:
Navarese, EP, Kolodziejczak, M, Dimitroulis, D, Wolff, G, Busch, HL, Devito, F, Sionis, A, Ciccone, MM
Publicada:
1 ene 2016
Resumen:
Statins are recommended as first-line therapy for patients with hypercholesterolaemia. A sizable proportion of patients, however, does not reach therapeutic goals, is statin intolerant, or, despite optimal statin therapy, is at high risk of ischaemic events. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in lipid metabolism and several comorbidities. Monoclonal antibodies targeting PCSK9 are a new lipid-lowering approach with the potential to improve clinical outcomes in patients with dyslipidaemia. In this review, we discuss current experimental and clinical evidence of the role of PCSK9 and its inhibition on lipid metabolism and several pathologic conditions with a focus on clinical outcomes. A state-of-the-art analysis of current clinical evidence and future directions on PCSK9 and its inhibition is provided.
Filiaciones:
Navarese, EP:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Dusseldorf, Div Cardiol Pulmonol & Vasc Med, Dept Internal Med, Moorenstr 5, D-40225 Dusseldorf, Germany
Kolodziejczak, M:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Nicolaus Copernicus, Coll Med Bydgoszcz, Torun, Poland
Dimitroulis, D:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Dusseldorf, Div Cardiol Pulmonol & Vasc Med, Dept Internal Med, Moorenstr 5, D-40225 Dusseldorf, Germany
Wolff, G:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Dusseldorf, Div Cardiol Pulmonol & Vasc Med, Dept Internal Med, Moorenstr 5, D-40225 Dusseldorf, Germany
Busch, HL:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Dusseldorf, Div Cardiol Pulmonol & Vasc Med, Dept Internal Med, Moorenstr 5, D-40225 Dusseldorf, Germany
Devito, F:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Bari, DETO, Bari, Italy
Sionis, A:
Hosp Santa Creu & Sant Pau, Dept Cardiol, Intens Cardiac Care Unit, Barcelona, Spain
Ciccone, MM:
MED Res Network, SIRIO, Dusseldorf, Germany
Univ Bari, DETO, Bari, Italy
Bronze, Green Published
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