How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
Por:
Lopez, F, Williams, MD, Cardesa, A, Hunt, JL, Strojan, P, Rinaldo, A, Nixon, IJ, Rodrigo, JP, Saba, NF, Mendenhall, WM, Quer, M, Suarez, C, Ferlito, A
Publicada:
1 jul 2017
Resumen:
Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.
Filiaciones:
Lopez, F:
Hosp Univ Cent Asturias, Dept Otolaryngol, Ave Roma S-N, Oviedo 33011, Asturias, Spain
Univ Oviedo, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Univ Oviedo, CIBERONC, ISCIII, Oviedo, Spain
Williams, MD:
Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
Cardesa, A:
Univ Barcelona, Hosp Clin, Dept Anat Pathol, Barcelona, Spain
Hunt, JL:
Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA
Strojan, P:
Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia
Rinaldo, A:
Univ Udine, Sch Med, Udine, Italy
Nixon, IJ:
Univ Edinburgh, Dept Surg, Edinburgh, Midlothian, Scotland
Univ Edinburgh, Dept Otolaryngol Head & Neck Surg, Edinburgh, Midlothian, Scotland
Rodrigo, JP:
Hosp Univ Cent Asturias, Dept Otolaryngol, Ave Roma S-N, Oviedo 33011, Asturias, Spain
Univ Oviedo, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Univ Oviedo, CIBERONC, ISCIII, Oviedo, Spain
Saba, NF:
Emory Univ, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
Mendenhall, WM:
Univ Florida, Dept Radiat Oncol, Gainesville, FL USA
Quer, M:
Hosp Santa Creu & Sant Pau, Dept Otolaryngol, Barcelona, Spain
Suarez, C:
Univ Oviedo, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Univ Oviedo, CIBERONC, ISCIII, Oviedo, Spain
Ferlito, A:
Int Head & Neck Sci Grp, Padua, Italy
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