GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidence
Por:
Guyatt, GH, Ebrahim, S, Alonso-Coello, P, Johnston, BC, Mathioudakis, AG, Briel, M, Mustafa, RA, Sun, X, Walter, SD, Heels-Ansdell, D, Neumann, I, Kahale, LA, Iorio, A, Meerpohl, J, Schunemann, HJ, Akl, EA
Publicada:
1 jul 2017
Resumen:
Objective: To provide GRADE guidance for assessing risk of bias across an entire body of evidence consequent on missing data for systematic reviews of both binary and continuous outcomes.
Study Design and Setting: Systematic survey of published methodological research, iterative discussions, testing in systematic reviews, and feedback from the GRADE Working Group.
Results: Approaches begin with a primary meta-analysis using a complete case analysis followed by sensitivity meta-analyses imputing, in each study, data for those with missing data, and then pooling across studies. For binary outcomes, we suggest use of "plausible worst case" in which review authors assume that those with missing data in treatment arms have proportionally higher event rates than those followed successfully. For continuous outcomes, imputed mean values come from other studies within the systematic review and the standard deviation (SD) from the median SDs of the control arms of all studies.
Conclusions: If the results of the primary meta-analysis are robust to the most extreme assumptions viewed as plausible, one does not rate down certainty in the evidence for risk of bias due to missing participant outcome data. If the results prove not robust to plausible assumptions, one would rate down certainty in the evidence for risk of bias. (C) 2017 Elsevier Inc. All. rights reserved.
Filiaciones:
Guyatt, GH:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
McMaster Univ, Dept Med, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Ebrahim, S:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Hosp Sick Children Res Inst, Child Hlth Evaluat Sci, Systemat Overviews Adv Res Technol SORT, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Alonso-Coello, P:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
CIBERESP IIB St Pau, Iberoamer Cochrane Ctr, 4th Floor,C St Antoni Maria Claret 171, Barcelona 08041, Spain
Johnston, BC:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Hosp Sick Children Res Inst, Child Hlth Evaluat Sci, Systemat Overviews Adv Res Technol SORT, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Univ Toronto, Hosp Sick Children, Dept Anesthesia & Pain Med, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Univ Toronto, Dalla Lana Sch Publ Hlth, Inst Hlth Policy Management & Evaluat, 155 Coll St, Toronto, ON M5T 3M7, Canada
Mathioudakis, AG:
CIBERESP IIB St Pau, Iberoamer Cochrane Ctr, 4th Floor,C St Antoni Maria Claret 171, Barcelona 08041, Spain
Briel, M:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Univ Hosp Basel, Basel Inst Clin Epidemiol & Biostat, Dept Clin Res, Hebelstr 10, CH-4056 Basel, Switzerland
Mustafa, RA:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Univ Kansas, Med Ctr, Dept Internal Med, 3901 Rainbow Blvd,MS3002, Kansas City, KS 66103 USA
Sun, X:
Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu 610041, Sichuan, Peoples R China
Walter, SD:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Heels-Ansdell, D:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Neumann, I:
Pontificia Univ Catolica Chile, Dept Internal Med, Av Libertador Bernardo OHiggins 340, Santiago, Region Metropol, Chile
Kahale, LA:
Amer Univ Beirut, Dept Internal Med, Beirut 11072020, Lebanon
Iorio, A:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
McMaster Univ, Dept Med, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Meerpohl, J:
Univ Freiburg, Med Ctr, Cochrane Germany, Breisacher Str 153, D-79110 Freiburg, Germany
Univ Paris 05, Sorbonne Paris Cite, Ctr Rech Epidemiol & Stat, INSERM,Cochrane France,Hop Hotel Dieu,U1153, 1 Pl Parvis Notre Dame, F-75181 Paris 04, France
Schunemann, HJ:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
McMaster Univ, Dept Med, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Akl, EA:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1200 Main St West, Hamilton, ON L8S 4K1, Canada
Amer Univ Beirut, Dept Internal Med, Beirut 11072020, Lebanon
Green Submitted
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