Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study
Por:
Pereira, MP, Hoffmann, V, Weisshaar, E, Wallengren, J, Halvorsen, JA, Garcovich, S, Misery, L, Brenaut, E, Savk, E, Potekaev, N, Lvov, A, Bobko, S, Szepietowski, JC, Reich, A, Bozek, A, Legat, FJ, Metz, M, Streit, M, Serra-Baldrich, E, Goncalo, M, Storck, M, Greiwe, I, Nau, T, Steinke, S, Dugas, M, Stander, S, Zeidler, C, EPP Consensus Conf Participants 20
Publicada:
1 oct 2020
Ahead of Print:
1 may 2020
Resumen:
Background Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking.
Objectives Aim of this pan-European multicentre cross-sectional study was to establish the clinical profile of CNPG, including its associated burden.
Methods Fifteen centres from 12 European countries recruited CNPG patients presenting at the centre or using the centres' own databases. Patients were asked to complete a questionnaire in paper or electronic format. Demography, current co-morbidities, underlying disease, itch intensity, additional sensory symptoms, quality of life, highest burden and emotional experience of itch were assessed.
Results A total of 509 patients (210 male, median age: 64 years [52; 72]) were enrolled. Of these, 406 reported itch and CNPG lesions in the previous 7 days and qualified to complete the whole questionnaire. We recorded moderate to severe worst itch intensity scores in the previous 24 h. Scores were higher in patients with lower educational levels and those coming from Eastern or Southern Europe. Most patients experience itch often or always (71%) and report that their everyday life is negatively affected (53%). Itch intensity was considered to be the most burdensome aspect of the disease by 49% of the patients, followed by the visibility of skin lesions (21%) and bleeding of lesions (21%). The majority of patients was unaware of an underlying condition contributing to CNPG (64%), while psychiatric diseases were the conditions most often mentioned in association with CNPG (19%).
Conclusions This multicentre cross-sectional study shows that itch is the dominant symptom in CNPG and reveals that the profile of the disease is similar throughout Europe.
Filiaciones:
Pereira, MP:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Hoffmann, V:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Weisshaar, E:
Heidelberg Univ, Dept Dermatol, Occupat Med, Heidelberg, Germany
Wallengren, J:
Dept Clin Sci Lund, Dermatol & Venereol, Lund, Sweden
Skane Univ Hosp, Lund, Sweden
Halvorsen, JA:
Univ Oslo, Oslo Univ Hosp, Dept Dermatol, Oslo, Norway
Garcovich, S:
Univ Cattolica Sacro Cuore, Inst Dermatol, F Policlin A Gemelli IRCCS, Rome, Italy
Misery, L:
Univ Hosp Brest, Dept Dermatol, Brest, France
Brenaut, E:
Univ Hosp Brest, Dept Dermatol, Brest, France
Savk, E:
Adnan Menderes Univ, Dept Dermatol, Aydin, Turkey
Potekaev, N:
Moscow Sci & Pract Ctr Dermatovenerol & Cosmetol, Moscow, Russia
Lvov, A:
Moscow Sci & Pract Ctr Dermatovenerol & Cosmetol, Moscow, Russia
Bobko, S:
Moscow Sci & Pract Ctr Dermatovenerol & Cosmetol, Moscow, Russia
Szepietowski, JC:
Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland
Reich, A:
Univ Rzeszow, Dept Dermatol, Rzeszow, Poland
Bozek, A:
Univ Informat Technol & Management, Sch Med, Dept Dermatol, Rzeszow, Poland
Legat, FJ:
Med Univ Graz, Dept Dermatol, Graz, Austria
Metz, M:
Charit Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany
Streit, M:
Kantonsspital Aarau, Dept Dermatol, Aarau, Switzerland
Serra-Baldrich, E:
St Pau Hosp, Dept Dermatol, Barcelona, Spain
Goncalo, M:
Univ Coimbra, Univ Hosp, Dept Dermatol, Coimbra, Portugal
Univ Coimbra, Fac Med, Coimbra, Portugal
Storck, M:
Univ Munster, Inst Med Informat, Munster, Germany
Greiwe, I:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Nau, T:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Steinke, S:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Dugas, M:
Univ Munster, Inst Med Informat, Munster, Germany
Stander, S:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Zeidler, C:
Univ Hosp Mumster, Dept Dermatol, Munster, Germany
Univ Hosp Mumster, Ctr Chron Pruritus, Munster, Germany
Hybrid Gold, Green Published
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