Efficacy of beta-Lactam/beta-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-beta-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia


Por: Gudiol, C, Royo-Cebrecos, C, Abdala, E, Akova, M, Alvarez, R, Maestro-de La Calle, G, Cano, A, Cervera, C, Clemente, WT, Martin-Davila, P, Freifeld, A, Gomez, L, Gottlieb, T, Gurgui, M, Herrera, F, Manzur, A, Maschmeyer, G, Meije, Y, Montejo, M, Peghin, M, Rodriguez-Bano, J, Ruiz-Camps, I, Sukiennik, TC, Tebe, C, Carratala, J

Publicada: 1 ago 2017
Resumen:
beta-Lactam/beta-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum beta-lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem-sparing alternatives for the treatment of BSI due to ESBLs in these patients.

Filiaciones:
Gudiol, C:
 Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain

 Duran & Reynals Hosp, ICO, Barcelona, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Royo-Cebrecos, C:
 Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Abdala, E:
 Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Sao Paulo, Brazil

Akova, M:
 Hacettepe Univ, Sch Med, Ankara, Turkey

Alvarez, R:
 Univ Seville, CSIC, Univ Hosp Virgen Rocio & Virgen Macarena, Inst Biomed Seville IBiS,Infect Dis Res Grp,Clin, Seville, Spain

Maestro-de La Calle, G:
 Univ Complutense, Sch Med, Octubre Univ Hosp 12, Inst Invest Hosp Octubre 12 i 12,Infect Dis Unit, Madrid, Spain

Cano, A:
 UCO, Reina Sofia Univ Hosp, IMIBIC, Cordoba, Spain

Cervera, C:
 Univ Alberta Hosp, Edmonton, AB, Canada

Clemente, WT:
 Univ Fed Minas Gerais, Hosp Clin, Digest Transplant Serv, Belo Horizonte, MG, Brazil

Martin-Davila, P:
 Hosp Ramon & Cajal, Infect Dis Dept, Madrid, Spain

Freifeld, A:
 Univ Nebraska, Med Ctr, Internal Med Infect Dis Sect, Omaha, NE 68182 USA

Gomez, L:
 Univ Hosp Mutua Terrassa, Internal Med, Barcelona, Spain

Gottlieb, T:
 Concord Hosp, Dept Microbiol & Infect Dis, Concord, NSW, Australia

Gurgui, M:
 Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain

 Univ Autonoma Barcelona, Inst Invest Biomed Sant Pau, Barcelona, Spain

Herrera, F:
 CEMIC, Dept Med, Infect Dis Sect, Buenos Aires, DF, Argentina

Manzur, A:
 Hosp Rawson, Infect Dis, San Juan, Argentina

Maschmeyer, G:
 Charite, Med Sch, Acad Teaching Hosp, Dept Hematol Oncol & Palliat Care,Klinikum Ernst, Berlin, Germany

Meije, Y:
 Barcelona Hosp, SCIAS, Internal Med Dept, Infect Dis Unit, Barcelona, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Montejo, M:
 Cruces Univ Hosp, Infect Dis Unit, Bilbao, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Peghin, M:
 Santa Maria Misericordia Univ Hosp, Infect Dis Div, Udine, Italy

Rodriguez-Bano, J:
 Univ Seville, Univ Hosp Virgen Macarena & Virgen Rocio IBiS, Dept Med, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Ruiz-Camps, I:
 Vall Hebron Univ Hosp, Infect Dis Dept, Barcelona, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain

Sukiennik, TC:
 Hosp Santa Casa Misericordia Porto Alegre, Porto Alegre, RS, Brazil

Tebe, C:
 Rovira & Virgili Univ, Inst Biomed Res Bellvitge, Stat Advisory Serv, Tarragona, Spain

Carratala, J:
 Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Infect Dis Dept, Barcelona, Spain

 Inst Salud Carlos III, REIPI Spanish Network Res Infect Dis, Madrid, Spain
ISSN: 00664804
Editorial
AMER SOC MICROBIOLOGY, 1752 N ST NW, WASHINGTON, DC 20036-2904 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 61 Número: 8
Páginas:
WOS Id: 000406259400008
ID de PubMed: 28584145
imagen Green Published

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