The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Por:
Bos, I, Vos, SJ, Frolich, L, Kornhuber, J, Wiltfang, J, Maier, W, Peters, O, Ruther, E, Engelborghs, S, Niemantsverdriet, E, De Roeck, EE, Tsolaki, M, Freund-Levim, Y, Johannsen, P, Vandenberghe, R, Lleo, A, Alcolea, D, Frisoni, GB, Galluzzi, S, Nobili, F, Morbelli, S, Drzezga, A, Didic, M, van Berckel, BN, Salmon, E, Bastin, C, Dauby, S, Santana, I, Baldeiras, I, de Mendonca, A, Silva, D, Wallin, A, Nordlund, A, Coloma, PM, Wientzek, A, Alexander, M, Novak, GP, Gordon, MF, Wallin, AK, Hampel, H, Soininen, H, Herukka, SK, Scheltens, P, Verhey, FR, Visser, PJ
Publicada:
1 ago 2017
Resumen:
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.
Filiaciones:
Bos, I:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Univ Singel 40,Box 34,POB 616, NL-6200 MD Maastricht, Netherlands
Vos, SJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Univ Singel 40,Box 34,POB 616, NL-6200 MD Maastricht, Netherlands
Frolich, L:
Heidelberg Univ, Zentralinst Seel Gesundheit, Dept Geriatr Psychiat, Mannheim, Germany
Kornhuber, J:
Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany
Wiltfang, J:
Georg August Univ, UMC, Dept Psychiat & Psychotherapy, Gottingen, Germany
Maier, W:
Univ Bonn, German Ctr Neurodegenerat Dis DZNE, Dept Psychiat & Psychotherapy, Bonn, Germany
Peters, O:
Charite, Dept Psychiat & Psychotherapy, Berlin, Germany
Ruther, E:
Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Engelborghs, S:
Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol & Memory Clin, Antwerp, Belgium
Univ Antwerp, Ref Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Niemantsverdriet, E:
Univ Antwerp, Ref Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
De Roeck, EE:
Univ Antwerp, Ref Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Vrije Univ Brussel, Dept Clin & Lifespan Psychol, Brussels, Belgium
Tsolaki, M:
Aristotle Univ Thessaloniki, G Papanicolau Gen Hosp, Memory & Dementia Ctr, Dept Neurol 3, Thessaloniki, Greece
Freund-Levim, Y:
Karolinska Inst, Caring Sci & Soc NVS, Dept Neurobiol, Div Clin Geriatr, Huddinge, Sweden
Karolinska Univ, Dept Geriatr Med, Huddinge Hosp, Stockholm, Sweden
Johannsen, P:
Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Copenhagen, Denmark
Vandenberghe, R:
Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
Katholieke Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium
Lleo, A:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Frisoni, GB:
Univ Hosp, Geneva Neurosci Ctr, Geneva, Switzerland
Univ Geneva, Geneva, Switzerland
IRCCS San Giovanni Dio Fatebenefratelli, Brescia, Italy
Galluzzi, S:
IRCCS San Giovanni Dio Fatebenefratelli, Brescia, Italy
Nobili, F:
Univ Genoa, Dept Neurosci DINOGMI, Clin Neurol, Genoa, Italy
IRCCS AOU San Martino IST, Genoa, Italy
Morbelli, S:
Univ Genoa, Dept Hlth Sci DISSAL, Nucl Med, IRCCS AOU San Martino IST, Genoa, Italy
Drzezga, A:
Univ Cologne, Dept Nucl Med, Cologne, Germany
Didic, M:
Hop La Timone, AP HM, Serv Neurol & Neuropsychol, Marseille, France
Aix Marseille Univ, INSERM, Inst Neurosci Syst, Marseille, France
van Berckel, BN:
Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands
Salmon, E:
Univ Liege, GIGA CRC Vivo Imaging, Liege, Belgium
Bastin, C:
Univ Liege, GIGA CRC Vivo Imaging, Liege, Belgium
Dauby, S:
CHU Liege, Dept Neurol & Memory Clin, Liege, Belgium
Santana, I:
CHU Liege, Dept Neurol & Memory Clin, Liege, Belgium
Baldeiras, I:
Ctr Hosp, Ctr Neurosci & Cell Biol, Fac Med, Dept Neurol, Coimbra, Portugal
Univ Coimbra, Coimbra, Portugal
Soininen, H:
Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
Kuopio Univ Hosp, Neuroctr, Neurol, Kuopio, Finland
Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Herukka, SK:
Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
Kuopio Univ Hosp, Neuroctr, Neurol, Kuopio, Finland
Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Scheltens, P:
Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Verhey, FR:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Univ Singel 40,Box 34,POB 616, NL-6200 MD Maastricht, Netherlands
Visser, PJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Univ Singel 40,Box 34,POB 616, NL-6200 MD Maastricht, Netherlands
Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Univ Lisbon, Inst Mol Med & Fac Med, Lisbon, Portugal.
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden.
F Hoffmann Roche Ltd, Pharmaceut Div, Real World Data Sci RWD S Neurosci & Established, Basel, Switzerland.
Roche Prod Ltd, PDB RWD Real World Data, Welwyn Garden City, Herts, England.
Epidemiolog Beratung & Literatur Rech Conepi, Herrsching, Germany.
Janssen Pharmaceut Res & Dev, Titusville, NJ USA.
Boehringer Ingelheim Pharmaceut Inc, 90 E Ridge POB 368, Ridgefield, CT 06877 USA.
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden.
Univ Paris 06, AXA Res Fund & UPMC Chair, IM2A, Sorbonne Univ,Paris 06, 47 Blvd Hop, Paris 13, France.
Univ Paris 06, Inst Cerveau & Moelle Epiniere ICM, Dept Neurol, Hop Pitie Salpetriere, 47 Blvd Hop, Paris 13, France.
Green Accepted, Green Published
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