Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia
Por:
Nikolajeva, O, Rocha, V, Danby, R, Ruggeri, A, Volt, F, Baudoux, E, Gomez, SG, Koegler, G, Larghero, J, Lecchi, L, Martinez, MS, Navarrete, C, Pouthiers, F, Querol, S, Kenzey, C, Szydlo, R, Gluckman, E, Madrigal, A
Publicada:
1 oct 2017
Resumen:
Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed. CBUs were provided by the European Cord Blood Banks. The median follow-up time for live patients was 59.9 months. The recipients of CMV-seropositive and -seronegative CBUs showed a comparable RI (33% versus 35%, respectively, P=.6) and 2-year cumulative incidence of NRM (31% versus 32%, respectively, P =.5). We conclude that CBU CMV serostatus did not influence RI and NRM in de novo acute leukemia patients after allo-UCBT and should not be included as a criteria for cord blood choice. (C) 2017 American Society for Blood and Marrow Transplantation.
Filiaciones:
Nikolajeva, O:
Anthony Nolan Res Inst, London, England
UCL, Canc Inst, London, England
Rocha, V:
Univ Oxford, Churchill Hosp, Dept Haematol, Oxford, England
Eurocord, Hop St Louis, Paris, France
Principal Monaco, Ctr Sci Monaco, Monaco, Monaco
Fac Med Univ, Hosp Clin, Serv Hematol Hemoterapia & Terapia Celular, Sao Paulo, Brazil
Danby, R:
Anthony Nolan Res Inst, London, England
Ruggeri, A:
Eurocord, Hop St Louis, Paris, France
Hop St Antoine, Serv Hematol & Therapie Cellularie, Paris, France
Volt, F:
Eurocord, Hop St Louis, Paris, France
Principal Monaco, Ctr Sci Monaco, Monaco, Monaco
Baudoux, E:
Univ Liege, NetCord Fdn & Liege Cord Blood Bank, Liege, Belgium
Gomez, SG:
Banc Sang Teixits, Barcelona, Spain
Koegler, G:
Univ Dusseldorf, Dusseldorf Cord Blood Bank, Dusseldorf, Germany
Larghero, J:
Hop St Louis, AP HP, Unite Therapie Cellulaire, Paris, France
Lecchi, L:
Ctr Transfus Med Cellular Therapy & Cryobiol, Milan, Italy
Martinez, MS:
Banc Sang Teixits, Barcelona, Spain
Navarrete, C:
NHS Blood & Transplant, NHS Cord Blood Bank, London, England
Pouthiers, F:
Besancon Cord Blood Bank Etab Francais Sang, Besancon, France
Querol, S:
Banc Sang Teixits, Barcelona, Spain
Kenzey, C:
Eurocord, Hop St Louis, Paris, France
Principal Monaco, Ctr Sci Monaco, Monaco, Monaco
Szydlo, R:
Imperial Coll London, London, England
Gluckman, E:
Eurocord, Hop St Louis, Paris, France
Principal Monaco, Ctr Sci Monaco, Monaco, Monaco
Madrigal, A:
Anthony Nolan Res Inst, London, England
UCL, Canc Inst, London, England
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