Amyloid-beta, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data
Por:
Bos, I, Vos, SJB, Jansen, WJ, Vandenberghe, R, Gabel, S, Estanga, A, Ecay-Torres, M, Tomassen, J, den Braber, A, Lleo, A, Sala, I, Wallin, A, Kettunen, P, Molinuevo, JL, Rami, L, Chetelat, G, de la Sayette, V, Tsolaki, M, Freund-Levi, Y, Johannsen, P, Novak, GP, Ramakers, I, Verhey, FR, Visser, PJ
Publicada:
25 jun 2018
Resumen:
We investigated whether amyloid-beta (A beta) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had A beta status and neuropsychological data available. Linear mixed models were used to assess the associations of Ali and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B). All test except the VFT were associated with status and this influence was augmented by age. We found no influence of tau on any of the cognitive tests. For the AVLT Immediate and Delayed recall and the TMT part A and B, we calculated norms in individuals without A beta pathology (A beta- norms), which we validated in an independent memory-clinic cohort by comparing their predictive accuracy to published norms. For memory tests, the A beta- norms rightfully identified an additional group of individuals at risk of dementia. For non-memory test we found no difference. We confirmed the relationship between Ao and cognition in cognitively normal individuals. The Af3- norms for memory tests in combination with published norms improve prognostic accuracy of dementia.
Filiaciones:
Bos, I:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vos, SJB:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Jansen, WJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vandenberghe, R:
Univ Hosp Leuven, Leuven, Belgium
Katholieke Univ Leuven, Lab Cognit Neurol, Dept Neurosci, Leuven, Belgium
Gabel, S:
Katholieke Univ Leuven, Lab Cognit Neurol, Dept Neurosci, Leuven, Belgium
Katholieke Univ Leuven, Alzheimer Res Ctr, Leuven, Belgium
Estanga, A:
CITA Alzheimer Fdn, Ctr Res & Adv Therapies, San Sebastian, Spain
Ecay-Torres, M:
CITA Alzheimer Fdn, Ctr Res & Adv Therapies, San Sebastian, Spain
Tomassen, J:
Vrije Univ Amsterdam, VU Univ Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, VU Univ Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
den Braber, A:
Vrije Univ Amsterdam, VU Univ Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, VU Univ Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
Lleo, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona 9, Spain
Sala, I:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona 9, Spain
Wallin, A:
Univ Gothenburg, Sect Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Kettunen, P:
Univ Gothenburg, Sect Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
Molinuevo, JL:
Consorci Inst Invest Biomed August Pi I Sunyer ID, Alzheimers Dis & Other Cognit Disorders Unit, Hosp Clin, Barcelona, Spain
Univ Pompeu Fabra, Barcelona Beta Brain Res Ctr, Barcelona, Spain
Rami, L:
Consorci Inst Invest Biomed August Pi I Sunyer ID, Alzheimers Dis & Other Cognit Disorders Unit, Hosp Clin, Barcelona, Spain
Chetelat, G:
Univ Caen Normandie, INSERM, UMR S U1237, GIP Cyceron, Caen, France
de la Sayette, V:
Univ Caen Normandie, INSERM, U1077, Ecole Prat Hautes Etud, Caen, France
CHU Caen, Serv Neurol, Caen, France
Tsolaki, M:
Univ Gen Hosp Thessaloniki AHEPA, Dept Neurol 1, Thessaloniki, Greece
Freund-Levi, Y:
Karolinska Inst, Dept Neurobiol Caring Sci & Soc NVS, Div Clin Geriatr, Stockholm, Sweden
Karolinska Univ Hosp Huddinge, Karolinska Institutet, Dept Geriatr Med, Stockholm, Sweden
Norrtalje Hosp Tiohundra, Dept Psychiat, Norrtalje, Sweden
Johannsen, P:
Univ Copenhagen, Copenhagen Univ Hosp, Danish Dementia Res Ctr, Rigshosp, Copenhagen, Denmark
Novak, GP:
Janssen Pharmaceut Res & Dev, Titusville, NJ USA
Ramakers, I:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Verhey, FR:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Visser, PJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vrije Univ Amsterdam, VU Univ Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, VU Univ Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Green Published, gold
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