Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
Por:
Bancroft, EK, Saya, S, Page, EC, Myhill, K, Thomas, S, Pope, J, Chamberlain, A, Hart, R, Glover, W, Cook, J, Rosario, DJ, Helfand, BT, Selkirk, CH, Davidson, R, Longmuir, M, Eccles, DM, Gadea, N, Brewer, C, Barwell, J, Salinas, M, Greenhalgh, L, Tischkowitz, M, Henderson, A, Evans, DG, Buys, SS, Eeles, RA, Aaronson, NK, Eeles, R, Bancroft, E, Page, E, Kote-Jarai, Z, Ardern-Jones, A, Bangma, C, Castro, E, Dearnaley, D, Falconer, A, Foster, C, Gronberg, H, Hamdy, FC, Johannsson, OT, Khoo, V, Eccles, D, Lilja, H, Evans, G, Eyfjord, J, Lubinski, J, Maehle, L, Mikropoulos, C, Millner, A, Mitra, A, Offman, J, Moynihan, C, Rennert, G, Suri, M, Dias, A, Taylor, N, D'Mello, L, Pope, J, James, P, Mitchell, G, Shanley, S, Richardson, K, McKinley, J, Petelin, L, Murphy, M, Mascarenhas, L, Murphy, D, Lam, J, Taylor, L, Miller, C, Stapleton, A, Chong, M, Suthers, G, Poplawski, N, Tucker, K, Andrews, L, Duffy, J, Millard, R, Ward, R, Williams, R, Stricker, P, Kirk, J, Bowman, M, Patel, M, Harris, M, O'Connell, S, Hunt, C, Smyth, C, Frydenberg, M, Lindeman, G, Shackleton, K, Morton, C, Susman, R, McGaughran, J, Boon, M, Pachter, N, Townshend, S, Schofield, L, Nicholls, C, Spigelman, A, Gleeson, M, Amor, D, Burke, J, Patterson, B, Swindle, P, Scott, R, Foulkes, W, Boshari, T, Aprikian, A, Jensen, T, Bojeson, A, Osther, P, Skytte, AB, Cruger, D, Tondering, MK, Gerdes, AM, Schmutzler, R, Rhiem, K, Wihler, P, Kast, K, Griebsch, C, Johannsson, O, Stefansdottir, V, Murthy, V, Sarin, R, Awatagiri, K, Ghonge, S, Kowtal, P, Mulgund, G, Gallagher, D, Bambury, R, Farrell, M, Gallagher, F, Kiernan, I, Friedman, E, Chen-Shtoyerman, R, Basevitch, A, Leibovici, D, Melzer, E, Ben-Yehoshua, SJ, Nicolai, N, Radice, P, Valdagni, R, Magnani, T, Gay, S, Teo, SH, Tan, HM, Yoon, SY, Thong, MK, Vasen, H, Ringleberg, J, van Asperen, C, Kiemeney, B, van Zelst-Stams, W, Ausems, MGEM, van der Luijt, RB, van Os, T, Ruijs, MWG, Adank, MA, Oldenburg, RA, Helderman-van den Enden, APTJM, Caanen, BAH, Oosterwijk, JC, Moller, P, Brennhovd, B, Medvik, H, Hanslien, E, Grindedal, EM, Cybulski, C, Wokolorczyk, D, Teixeira, M, Maia, S, Peixoto, A, Henrique, R, Oliveira, J, Goncalves, N, Araujo, L, Seixas, M, Souto, JP, Nogueira, P, Copakova, L, Zgajnar, J, Krajc, M, Vrecar, A, Capella, G, Cajal, TRY, Fisas, D, Mora, J, Esquena, S, Balmana, J, Morote, J, Liljegren, A, Hjalm-Eriksson, M, Ekdahl, KJ, Carlsson, S, George, A, Kemp, Z, Wiggins, J, Moss, C, Van As, N, Thompson, A, Ogden, C, Woodhouse, C, Kumar, P, Evans, DG, Bulman, B, Rothwell, J, Tricker, K, Wise, G, Mercer, C, McBride, D, Costello, P, Pearce, A, Torokwa, A, Paterson, J, Clowes, V, Taylor, A, Newcombe, B, Walker, L, Halliday, D, Stayner, B, Fleming-Brown, D, Snape, K, Hanson, H, Hodgson, S, Brice, G, Homfray, T, Hammond, C, Kohut, K, Anjum, U, Dearing, A, Mencias, M, Potter, A, Renton, C, Searle, A, Hill, K, Goodman, S, Garcia, L, Devlin, G, Everest, S, Nadolski, M, Douglas, F, Jobson, I, Paez, E, Donaldson, A, Tomkins, S, Langman, C, Jacobs, C, Pichert, G, Shaw, A, Kulkarni, A, Tripathi, V, Rose, S, Compton, C, Watson, M, Reinholtz, C, Brady, A, Dorkins, H, Melville, A, Kosicka-Slawinska, M, Cummings, C, Kiesel, V, Bartlett, M, Randhawa, K, Ellery, N, Side, L, Male, A, Simon, K, Rees, K, Tidey, L, Gurasashvili, J, Nevitt, L, Ingram, S, Howell, A, Rosario, D, Catto, J, Howson, J, Ong, KR, Chapman, C, Cole, T, Heaton, T, Hoffman, J, Burgess, L, Huber, C, Islam, F, Watt, C, Duncan, A, Kockelbergh, R, Mzazi, S, Dineen, A, Sattar, A, Kaemba, B, Sidat, Z, Patel, N, Siguake, K, Birt, A, Poultney, U, Umez-Eronini, N, Mom, J, Sutton, V, Cornford, P, Bermingham, N, Yesildag, P, Treherne, K, Griffiths, J, Cogley, L, Gott, H, Rubinstein, WS, Hulick, P, McGuire, M, Shevrin, D, Kaul, K, Weissman, S, Newlin, A, Vogel, K, Weiss, S, Hook, N, Buys, S, Goldgar, D, Conner, T, Venne, V, Stephenson, R, Dechet, C, Domchek, S, Powers, J, Rustgi, N, Strom, S, Arun, B, Davis, JW, Yamamura, Y, Obeid, E, Giri, V, Gross, L, Bealin, L, Cooney, K, Stoffel, E, Okoth, L
Publicada:
1 feb 2019
Resumen:
Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
Filiaciones:
Bancroft, EK:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Saya, S:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Page, EC:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Myhill, K:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Thomas, S:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Pope, J:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Chamberlain, A:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Hart, R:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham, W Midlands, England
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Glover, W:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham, W Midlands, England
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Rosario, DJ:
Royal Hallamshire Hosp, Dept Urol, Sheffield, S Yorkshire, England
Helfand, BT:
NorthShore Univ HealthSyst, John & Carol Walter Ctr Urol Hlth, Evanston, IL USA
Selkirk, CH:
NorthShore Univ HealthSyst, John & Carol Walter Ctr Urol Hlth, Evanston, IL USA
Davidson, R:
Queen Elizabeth Univ Hosp, Clin Genet Dept, Glasgow, Lanark, Scotland
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Longmuir, M:
Queen Elizabeth Univ Hosp, Clin Genet Dept, Glasgow, Lanark, Scotland
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Eccles, DM:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Univ Southampton, Fac Med, Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
Gadea, N:
Vali dHebron Univ Hosp, High Risk & Canc Prevent Clin, Barcelona, Spain
Hosp Valle De Hebron, Barcelona, Spain
Brewer, C:
Royal Devon & Exeter Hosp, Clin Genet Dept, Exeter, Devon, England
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Derriford Hosp, Plymouth, Devon, England
Barwell, J:
Univ Leicester, Dept Genet, Leicester, Leics, England
Univ Hosp Leicester, Clin Genet, Leicester, Leics, England
Leicester Royal Infirm, Leicester, Leics, England
Salinas, M:
Catalan Inst Oncol ICO IDIBELL CIBERONC, Hereditary Canc Programme, Barcelona, Spain
Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Greenhalgh, L:
Liverpool Womens Hosp, Cheshire & Mersey Clin Genet Serv, Liverpool, Merseyside, England
Tischkowitz, M:
Univ Cambridge, Acad Dept Med Genet, Cambridge, England
East Anglian Reg Genet Serv, Cambridge, England
Henderson, A:
Newcastle upon Tyne Hosp, Northern Genet Serv, Newcastle, NSW, Australia
Northern Clin Genet Serv, Newcastle, NSW, Australia
North Cumbria Univ Hosp Trust, Carlisle, England
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Ctr Genom Med, Manchester, Lancs, England
Buys, SS:
Univ Utah Hlth, Huntsman Canc Inst, Salt Lake City, UT USA
Eeles, RA:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Aaronson, NK:
Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands
Eeles, R:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Inst Canc Res, Coordinating Ctr, London, England
Bancroft, E:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Royal Marsden NHS Fdn Trust, London, England
Inst Canc Res, Coordinating Ctr, London, England
Page, E:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Inst Canc Res, Coordinating Ctr, London, England
Kote-Jarai, Z:
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Ardern-Jones, A:
Royal Marsden NHS Fdn Trust, London, England
Bangma, C:
Erasmus Univ, Med Ctr, Rotterdam, Netherlands
Castro, E:
CNIO, Madrid, Spain
Dearnaley, D:
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Falconer, A:
Imperial Coll Healthcare NHS Trust, London, England
Foster, C:
HCA Pathol Labs, London, England
Gronberg, H:
Univ Hosp, Umea, Sweden
Hamdy, FC:
Univ Oxford, Oxford, England
Johannsson, OT:
Landspitali Natl Univ Hosp Iceland, Reykjavik, Iceland
Khoo, V:
Royal Marsden NHS Fdn Trust, London, England
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Eccles, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Univ Southampton, Fac Med, Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
Wessex Clin Genet Serv, Southampton, Hants, England
Lilja, H:
New York & Univ Oxford, MSKCC, Oxford, England
Evans, G:
St Marys Hosp, Manchester, Lancs, England
Eyfjord, J:
Univ Iceland, Reykjavik, Iceland
Lubinski, J:
Int Hereditary Canc Ctr, Szczecin, Poland
Maehle, L:
Norwegian Radium Hosp, Oslo, Norway
Mikropoulos, C:
Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Millner, A:
Royal Marsden NHS Fdn Trust, London, England
Mitra, A:
Univ Coll London Hosp, London, England
Offman, J:
Kings Coll London, London, England
Moynihan, C:
Royal Marsden NHS Fdn Trust, London, England
Rennert, G:
CHS Natl Canc Control Ctr, Carmel Med Ctr, Haifa, Israel
Suri, M:
Nottingham City Hosp, Nottingham, England
Dias, A:
Inst Canc Res, Coordinating Ctr, London, England
Taylor, N:
Inst Canc Res, Coordinating Ctr, London, England
D'Mello, L:
Inst Canc Res, Coordinating Ctr, London, England
Pope, J:
Royal Marsden NHS Fdn Trust, Oncogenet Team, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
James, P:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
Royal Melbourne Hosp, Genet Med, Melbourne, Vic, Australia
Mitchell, G:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
Shanley, S:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Richardson, K:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
McKinley, J:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Petelin, L:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Murphy, M:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Mascarenhas, L:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Murphy, D:
Peter MacCallum Canc Ctr, Dept Urol, East Melbourne, Vic, Australia
Lam, J:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Taylor, L:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Miller, C:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Stapleton, A:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Chong, M:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Suthers, G:
SA Pathol Womens & Childrens Hosp, SA Clin Genet Serv, Adelaide, SA, Australia
Poplawski, N:
SA Pathol Womens & Childrens Hosp, SA Clin Genet Serv, Adelaide, SA, Australia
Tucker, K:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Andrews, L:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Duffy, J:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Millard, R:
Prince Wales Hosp, Dept Urol, Randwick, NSW, Australia
Ward, R:
UNSW, Prince Wales Clin Sch, Fac Med, Hereditary Canc Clin, Sydney, NSW, Australia
Williams, R:
UNSW, Prince Wales Clin Sch, Fac Med, Hereditary Canc Clin, Sydney, NSW, Australia
Stricker, P:
St Vincents Clin, Sydney, NSW, Australia
Kirk, J:
Westmead Hosp, Familial Canc Serv, Wentworthville, NSW, Australia
Westmead Inst Med Res, Ctr Canc Res, Westmead, NSW, Australia
Bowman, M:
Westmead Hosp, Familial Canc Serv, Wentworthville, NSW, Australia
Patel, M:
Westmead Hosp, Wentworthville, NSW, Australia
Harris, M:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
O'Connell, S:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Hunt, C:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Smyth, C:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Frydenberg, M:
Monash Med Ctr, Clayton, Vic, Australia
Lindeman, G:
Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Walter & Eliza Hall Inst Med Res, Stem Cells & Canc Div, Parkville, Vic, Australia
Univ Melbourne, Dept Med, Parkville, Vic, Australia
Shackleton, K:
Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Morton, C:
Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Susman, R:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
McGaughran, J:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Boon, M:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Pachter, N:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Univ Western Australia, Dept Paediat, Perth, WA, Australia
Townshend, S:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Schofield, L:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Nicholls, C:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Spigelman, A:
Hunter Family Canc Serv, NSW Allan Spigelman, Waratah, NSW, Australia
Univ New South Wales, St Vincents Clin Sch, Waratah, NSW, Australia
St Vincents Hosp, Kinghorn Canc Ctr, Hereditary Canc Clin, Sydney, NSW, Australia
Gleeson, M:
Hunter Family Canc Serv, NSW Allan Spigelman, Waratah, NSW, Australia
Amor, D:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Murdoch Childrens Res Inst, Parkville, Vic, Australia
Burke, J:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Patterson, B:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Swindle, P:
Mater Private Hosp, South Brisbane, Qld, Australia
Scott, R:
Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia
Victorian Canc Biobank, Carlton, Vic, Australia
Westmead Hosp, Ctr Canc Res, Dept Gynaecol Oncol Lab, Westmead, NSW, Australia
PathWest Clin Trials Lab, Nedlands, WA, Australia
Pathol Queensland Cent Lab Hlth Support Queenslan, QLD Dept Hlth, Herston, Qld, Australia
Foulkes, W:
McGill Univ, Montreal, PQ, Canada
Boshari, T:
McGill Univ, Montreal, PQ, Canada
Aprikian, A:
McGill Univ, Montreal, PQ, Canada
Jensen, T:
Vejle Hosp, Vejle, Denmark
Bojeson, A:
Vejle Hosp, Vejle, Denmark
Osther, P:
Vejle Hosp, Vejle, Denmark
Skytte, AB:
Vejle Hosp, Vejle, Denmark
Cruger, D:
Vejle Hosp, Vejle, Denmark
Tondering, MK:
Vejle Hosp, Vejle, Denmark
Gerdes, AM:
Odense Univ Hosp, Odense, Denmark
Schmutzler, R:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Wihler, P:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Kast, K:
Univ Hosp Dresden, Dresden, Germany
Griebsch, C:
Univ Hosp Dresden, Dresden, Germany
Johannsson, O:
Landspitali Natl Univ Hosp Iceland, Reykjavik, Iceland
Univ Hosp Iceland, Reykjavik, Iceland
Stefansdottir, V:
Univ Hosp Iceland, Reykjavik, Iceland
Murthy, V:
Tata Mem Hosp, Bombay, Maharashtra, India
Sarin, R:
Tata Mem Hosp, Bombay, Maharashtra, India
Awatagiri, K:
Tata Mem Hosp, Bombay, Maharashtra, India
Ghonge, S:
Tata Mem Hosp, Bombay, Maharashtra, India
Kowtal, P:
Tata Mem Hosp, Bombay, Maharashtra, India
Mulgund, G:
Tata Mem Hosp, Bombay, Maharashtra, India
Gallagher, D:
Mater Private Hosp, Dublin, Ireland
Bambury, R:
Mater Private Hosp, Dublin, Ireland
Farrell, M:
Mater Private Hosp, Dublin, Ireland
Gallagher, F:
Mater Private Hosp, Dublin, Ireland
Kiernan, I:
Mater Private Hosp, Dublin, Ireland
Friedman, E:
Cha Sheba Med Ctr, Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Chen-Shtoyerman, R:
Kaplan Med Ctr, Genet Inst, Gastroenterol Inst, Rehovot, Israel
Kaplan Med Ctr, Urol Dept, Rehovot, Israel
Basevitch, A:
Kaplan Med Ctr, Genet Inst, Gastroenterol Inst, Rehovot, Israel
Kaplan Med Ctr, Urol Dept, Rehovot, Israel
Leibovici, D:
Kaplan Med Ctr, Genet Inst, Gastroenterol Inst, Rehovot, Israel
Kaplan Med Ctr, Urol Dept, Rehovot, Israel
Melzer, E:
Kaplan Med Ctr, Genet Inst, Gastroenterol Inst, Rehovot, Israel
Kaplan Med Ctr, Urol Dept, Rehovot, Israel
Ben-Yehoshua, SJ:
Kaplan Med Ctr, Genet Inst, Gastroenterol Inst, Rehovot, Israel
Kaplan Med Ctr, Urol Dept, Rehovot, Israel
Nicolai, N:
Ist Nazl Tumori, Milan, Italy
Radice, P:
Ist Nazl Tumori, Milan, Italy
Valdagni, R:
Ist Nazl Tumori, Milan, Italy
Magnani, T:
Ist Nazl Tumori, Milan, Italy
Gay, S:
Ist Nazl Tumori, Milan, Italy
Teo, SH:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Univ Malaya, Kuala Lumpur, Malaysia
Tan, HM:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Yoon, SY:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Thong, MK:
Univ Malaya, Kuala Lumpur, Malaysia
Vasen, H:
STOET Stichting Opsporing Erfelijke Tumoren, Leiden, Netherlands
Ringleberg, J:
STOET Stichting Opsporing Erfelijke Tumoren, Leiden, Netherlands
van Asperen, C:
Leiden Univ, Med Ctr, Leiden, Netherlands
Kiemeney, B:
Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands
van Zelst-Stams, W:
Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands
Ausems, MGEM:
Univ Med Ctr Utrecht, Utrecht, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Utrecht, Netherlands
van Os, T:
Acad Med Ctr, Amsterdam, Netherlands
Ruijs, MWG:
Netherlands Canc Inst, Amsterdam, Netherlands
Adank, MA:
Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
Oldenburg, RA:
Erasmus MC, Rotterdam, Netherlands
Helderman-van den Enden, APTJM:
Univ Hosp Maastricht, Maastricht, Netherlands
Caanen, BAH:
Univ Hosp Maastricht, Maastricht, Netherlands
Oosterwijk, JC:
Univ Med Ctr Groningen, Groningen, Netherlands
Moller, P:
Norwegian Radium Hosp, Oslo, Norway
Brennhovd, B:
Norwegian Radium Hosp, Oslo, Norway
Medvik, H:
Norwegian Radium Hosp, Oslo, Norway
Hanslien, E:
Norwegian Radium Hosp, Oslo, Norway
Grindedal, EM:
Norwegian Radium Hosp, Oslo, Norway
Cybulski, C:
Int Hereditary Canc Ctr, Szczecin, Poland
Wokolorczyk, D:
Int Hereditary Canc Ctr, Szczecin, Poland
Teixeira, M:
Portuguese Oncol Inst, Lisbon, Portugal
Maia, S:
Portuguese Oncol Inst, Lisbon, Portugal
Peixoto, A:
Portuguese Oncol Inst, Lisbon, Portugal
Henrique, R:
Portuguese Oncol Inst, Lisbon, Portugal
Oliveira, J:
Portuguese Oncol Inst, Lisbon, Portugal
Goncalves, N:
Portuguese Oncol Inst, Lisbon, Portugal
Araujo, L:
Portuguese Oncol Inst, Lisbon, Portugal
Seixas, M:
Portuguese Oncol Inst, Lisbon, Portugal
Souto, JP:
Portuguese Oncol Inst, Lisbon, Portugal
Nogueira, P:
Portuguese Oncol Inst, Lisbon, Portugal
Copakova, L:
Natl Canc Inst, Bratislava Lucia Copakova, Bratislava, Slovakia
Zgajnar, J:
Inst Oncol, Ljubljana, Slovenia
Krajc, M:
Inst Oncol, Ljubljana, Slovenia
Vrecar, A:
Inst Oncol, Ljubljana, Slovenia
Capella, G:
Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Cajal, TRY:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Fisas, D:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Mora, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Esquena, S:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Balmana, J:
Hosp Valle De Hebron, Barcelona, Spain
Morote, J:
Hosp Valle De Hebron, Barcelona, Spain
Liljegren, A:
Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden
Hjalm-Eriksson, M:
Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden
Ekdahl, KJ:
Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden
Carlsson, S:
Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden
George, A:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Kemp, Z:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Wiggins, J:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Moss, C:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Van As, N:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Thompson, A:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Ogden, C:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Woodhouse, C:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Kumar, P:
Royal Marsden NHS Fdn Trust, Stockholm, Sweden
Evans, DG:
Manchester Reg Genet Serv, Manchester, Lancs, England
Bulman, B:
Manchester Reg Genet Serv, Manchester, Lancs, England
Rothwell, J:
Manchester Reg Genet Serv, Manchester, Lancs, England
Tricker, K:
Manchester Reg Genet Serv, Manchester, Lancs, England
Wise, G:
Wessex Clin Genet Serv, Southampton, Hants, England
Mercer, C:
Wessex Clin Genet Serv, Southampton, Hants, England
McBride, D:
Wessex Clin Genet Serv, Southampton, Hants, England
Costello, P:
Wessex Clin Genet Serv, Southampton, Hants, England
Pearce, A:
Wessex Clin Genet Serv, Southampton, Hants, England
Torokwa, A:
Wessex Clin Genet Serv, Southampton, Hants, England
Paterson, J:
East Anglian Reg Genet Serv, Cambridge, England
Clowes, V:
East Anglian Reg Genet Serv, Cambridge, England
North West Thames Reg Genet Serv, Harrow, Middx, England
Taylor, A:
East Anglian Reg Genet Serv, Cambridge, England
Newcombe, B:
East Anglian Reg Genet Serv, Cambridge, England
Walker, L:
Oxford Reg Genet Serv, Oxford, England
Halliday, D:
Oxford Reg Genet Serv, Oxford, England
Stayner, B:
Oxford Reg Genet Serv, Oxford, England
Fleming-Brown, D:
Oxford Reg Genet Serv, Oxford, England
Snape, K:
South West Thames Reg Genet Serv, London, England
Hanson, H:
South West Thames Reg Genet Serv, London, England
Hodgson, S:
South West Thames Reg Genet Serv, London, England
Brice, G:
South West Thames Reg Genet Serv, London, England
Homfray, T:
South West Thames Reg Genet Serv, London, England
Hammond, C:
South West Thames Reg Genet Serv, London, England
Kohut, K:
South West Thames Reg Genet Serv, London, England
Anjum, U:
South West Thames Reg Genet Serv, London, England
Dearing, A:
South West Thames Reg Genet Serv, London, England
Mencias, M:
South West Thames Reg Genet Serv, London, England
Potter, A:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Renton, C:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Searle, A:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Hill, K:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Goodman, S:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Garcia, L:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Devlin, G:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Everest, S:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Nadolski, M:
Peninsula Clin Genet Serv Exeter, Exeter, Devon, England
Douglas, F:
Northern Clin Genet Serv, Newcastle, NSW, Australia
Jobson, I:
Northern Clin Genet Serv, Newcastle, NSW, Australia
Paez, E:
Northern Clin Genet Serv, Newcastle, NSW, Australia
Donaldson, A:
South West Reg Genet Serv, Bristol, Avon, England
Tomkins, S:
South West Reg Genet Serv, Bristol, Avon, England
Langman, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Jacobs, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Pichert, G:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Shaw, A:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Kulkarni, A:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Tripathi, V:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Rose, S:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Compton, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
North East Thames Reg Genet Serv, Ne Thames, England
Watson, M:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Reinholtz, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Brady, A:
North West Thames Reg Genet Serv, Harrow, Middx, England
Dorkins, H:
North West Thames Reg Genet Serv, Harrow, Middx, England
Melville, A:
North West Thames Reg Genet Serv, Harrow, Middx, England
Kosicka-Slawinska, M:
North West Thames Reg Genet Serv, Harrow, Middx, England
Cummings, C:
North West Thames Reg Genet Serv, Harrow, Middx, England
Kiesel, V:
North West Thames Reg Genet Serv, Harrow, Middx, England
Bartlett, M:
North West Thames Reg Genet Serv, Harrow, Middx, England
Randhawa, K:
North West Thames Reg Genet Serv, Harrow, Middx, England
Ellery, N:
North West Thames Reg Genet Serv, Harrow, Middx, England
Side, L:
North East Thames Reg Genet Serv, Ne Thames, England
Male, A:
North East Thames Reg Genet Serv, Ne Thames, England
Simon, K:
North East Thames Reg Genet Serv, Ne Thames, England
Rees, K:
North East Thames Reg Genet Serv, Ne Thames, England
Tidey, L:
North East Thames Reg Genet Serv, Ne Thames, England
Gurasashvili, J:
North East Thames Reg Genet Serv, Ne Thames, England
Nevitt, L:
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Ingram, S:
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Howell, A:
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Rosario, D:
Royal Hallamshire Hosp, Dept Urol, Sheffield, S Yorkshire, England
Acad Urol Unit, Sheffield, S Yorkshire, England
Catto, J:
Acad Urol Unit, Sheffield, S Yorkshire, England
Howson, J:
Acad Urol Unit, Sheffield, S Yorkshire, England
Ong, KR:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Chapman, C:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Cole, T:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Heaton, T:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Hoffman, J:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Burgess, L:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Huber, C:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Islam, F:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Watt, C:
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Duncan, A:
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Kockelbergh, R:
Leicester Royal Infirm, Leicester, Leics, England
Mzazi, S:
Leicester Royal Infirm, Leicester, Leics, England
Dineen, A:
Leicester Royal Infirm, Leicester, Leics, England
Sattar, A:
Leicester Royal Infirm, Leicester, Leics, England
Kaemba, B:
Leicester Royal Infirm, Leicester, Leics, England
Sidat, Z:
Leicester Royal Infirm, Leicester, Leics, England
Patel, N:
Leicester Royal Infirm, Leicester, Leics, England
Siguake, K:
Leicester Royal Infirm, Leicester, Leics, England
Birt, A:
North Cumbria Univ Hosp Trust, Carlisle, England
Poultney, U:
North Cumbria Univ Hosp Trust, Carlisle, England
Umez-Eronini, N:
North Cumbria Univ Hosp Trust, Carlisle, England
Mom, J:
North Cumbria Univ Hosp Trust, Carlisle, England
Sutton, V:
Liverpool Womens Hosp, Cheshire & Mersey Clin Genet Serv, Liverpool, Merseyside, England
Cornford, P:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Bermingham, N:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Yesildag, P:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Treherne, K:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Griffiths, J:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Cogley, L:
Derriford Hosp, Plymouth, Devon, England
Gott, H:
Derriford Hosp, Plymouth, Devon, England
Rubinstein, WS:
Northshore Univ Healthsyst, Evanston, IL USA
Hulick, P:
Northshore Univ Healthsyst, Evanston, IL USA
McGuire, M:
Northshore Univ Healthsyst, Evanston, IL USA
Shevrin, D:
Northshore Univ Healthsyst, Evanston, IL USA
Kaul, K:
Northshore Univ Healthsyst, Evanston, IL USA
Weissman, S:
Northshore Univ Healthsyst, Evanston, IL USA
Newlin, A:
Northshore Univ Healthsyst, Evanston, IL USA
Vogel, K:
Northshore Univ Healthsyst, Evanston, IL USA
Weiss, S:
Northshore Univ Healthsyst, Evanston, IL USA
Hook, N:
Northshore Univ Healthsyst, Evanston, IL USA
Buys, S:
Univ Utah Hlth, Huntsman Canc Inst, Salt Lake City, UT USA
Domchek, S:
Univ Penn, Philadelphia, PA 19104 USA
Powers, J:
Univ Penn, Philadelphia, PA 19104 USA
Rustgi, N:
Univ Penn, Philadelphia, PA 19104 USA
Strom, S:
MD Anderson, Houston, TX USA
Arun, B:
MD Anderson, Houston, TX USA
Davis, JW:
MD Anderson, Houston, TX USA
Yamamura, Y:
MD Anderson, Houston, TX USA
Obeid, E:
Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
Giri, V:
Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
Gross, L:
Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
Bealin, L:
Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
Cooney, K:
Univ Michigan, Ann Arbor, MI 48109 USA
Stoffel, E:
Univ Michigan, Ann Arbor, MI 48109 USA
Okoth, L:
Univ Michigan, Ann Arbor, MI 48109 USA
Green Published, Green Accepted, hybrid
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