Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy
Por:
Company-Se, G, Nescolarde, L, Pajares, V, Torrego, A, Riu, PJ, Rosell, J, Bragos, R
Publicada:
1 ene 2022
Resumen:
This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0.001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs.
Filiaciones:
Company-Se, G:
Univ Politecn Cataluna, Dept Elect Engn, Barcelona 08034, Spain
Nescolarde, L:
Univ Politecn Cataluna, Dept Elect Engn, Barcelona 08034, Spain
Pajares, V:
Hosp Santa Creu & Sant Pau, Dept Resp Med, Barcelona 08041, Spain
Torrego, A:
Hosp Santa Creu & Sant Pau, Dept Resp Med, Barcelona 08041, Spain
Riu, PJ:
Univ Politecn Cataluna, Dept Elect Engn, Barcelona 08034, Spain
Rosell, J:
Univ Politecn Cataluna, Dept Elect Engn, Barcelona 08034, Spain
Bragos, R:
Univ Politecn Cataluna, Dept Elect Engn, Barcelona 08034, Spain
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