The role of attentional control over interference in minor hallucinations in Parkinson's disease
Por:
Bejr-kasem, H, Martinez-Horta, S, Pagonabarraga, J, Marin-Lahoz, J, Horta-Barba, A, Sampedro, F, Aracil-Bolanos, I, Perez-Perez, J, Campolongo, A, Izquierdo, C, Pascual-Sedano, B, Kulisevsky, J
Publicada:
1 sep 2022
Ahead of Print:
1 ago 2022
Resumen:
Background: Minor hallucinations in Parkinson's disease are associated with connectivity changes in attentional networks and increased risk of structured hallucinations. However, the clinical translation of these abnormalities in attention processes is not well-defined, and commonly used neuropsychological tests are not able to detect significant deficits in Parkinson's disease patients with isolated minor hallucinations. Objectives: To analyze the behavioral and electrophysiological correlates of minor hallucinations in Parkinson's disease during an attentional task assessing response inhibition and interference control. Methods: Fifty-five non-demented Parkinson's disease patients with (PD-mH; n = 27) and without minor hal-lucinations (PD-NH; n = 28) were included in the analysis. An Ericksen flanker task was performed to compare the effect of presenting congruent and incongruent stimuli on accuracy, reaction times and stimulus-locked event-related potentials morphology. Results: Although both groups showed equivalent performance in a standard neuropsychological assessment, in the flanker task accuracy rates were lower in the PD-mH group in incongruent trials (p = 0.005). In the event -related potentials, PD-mH patients showed increased amplitude of the N2 at Fz [t(53); p < 0.05] and decreased amplitude of the P300 at Pz [t(53); p < 0.05] for the incongruent trials. Conclusions: Parkinson's disease patients with isolated minor hallucinations were more susceptible to interfer-ence mediated by irrelevant stimuli and had less cognitive control for suppressing these interferences. The failure of these systems could precipitate the intrusion and overrepresentation of peripheral irrelevant stimuli perceived as minor hallucinations. The Ericksen flanker task could be used as a sensitive clinical marker of the attentional defects leading to hallucinations in Parkinson's disease.
Filiaciones:
Bejr-kasem, H:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Hosp Univ Vic, Barcelona, Spain
Martinez-Horta, S:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Pagonabarraga, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Hosp Santa Creu & Sant Pau, Neurol Dept, Movement Disorders Unit, Mas Casanovas 90, Barcelona 08041, Spain
Marin-Lahoz, J:
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Miguel Servet Univ Hosp, Neurol Dept, Zaragoza, Spain
Inst Invest Sanitaria Aragon, Zaragoza, Spain
Horta-Barba, A:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Sampedro, F:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Aracil-Bolanos, I:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Perez-Perez, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Campolongo, A:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Izquierdo, C:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Pascual-Sedano, B:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Kulisevsky, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Univ Autonoma Barcelona UAB, Med Dept, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
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